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    Recession-flation, Anti-War Ballads

    Weekly Market Commentary 29 October 2021
    by davefairtex

    Sunday, October 31, 2021, 4:00 PM

We saw some negative economic data this week:

  • Auto/light truck sales: -6.8% m/m, -33.9% y/y. Auto sales continue to plunge. “Shortages”. The drop in auto sales is nothing short of spectacular: peak of 18m in early 2021, currently at 12m.
  • GDP: +1.87% q/q, +8.78% y/y. That sounds good, but the expectation was for a vastly higher number.
  • Durable Goods: orders -0.38% m/m, shipments +0.41% m/m. This hints at – at least – a slight decline into next month. (orders = future, shipments = this month).
  • Personal Income: -1.06% m/m, +4.54% y/y. This also hints at a decline, coming soon.

The (trailing) economic releases hint of a recession in the offing. My guess: President Grandpa’s handlers see this too. Recessions are political disasters. Add inflation, and the disaster is magnified that much more. The desperation of the Grandpa-handlers to pass a multi-trillion-dollar debt-funded spending binge (“No Donor Left Behind”) is palpable.

Do we see any confirmation of this in commodity prices?

Well, “Doctor Copper” (so-called because it can “diagnose” economic problems ahead of time) is hinting at maybe trouble ahead. Dr Copper fell -2.89%, printed a bearish reversal, and is now in a downtrend in all 3 timeframes. It still remains above the 50 MA, so no collapse just yet. But the past two weeks look pretty negative. Maybe a double-top?

And how about lumber?

Well lumber was crushed this week, falling -13.99% and printing a strong bearish reversal pattern. It is in a near-term downtrend, and it is now back below all 3 moving averages. So that looks bearish too.

The master resource fell -1.42%, printed a mildly bearish weekly candle, and is now in a daily downtrend. It is back below the 9 MA. Call crude: very mildly bearish. It hasn’t really confirmed this possible-recession picture yet. Can we have oil shortages alongside a recession? That would certainly be bad if that happened.

The buck rallied strongly this week (+0.56%) with all the gains happening on Friday. Buck is back in a medium-term uptrend.

The 10-year rate plunged on the week, dropping -10 bp to 1.56%. This was a large move down. Looks like money is moving into the buck, and into the 10 year also. This could be the start of a safe-haven move.

So all that is – mostly – hinting at recession. Possibly. Except for crude. Recession-flation.

Gold fell -0.47%, moving back into a downtrend. Looks like gold ran into resistance at the 200 MA. Viewed in Euros, gold was unchanged – gold’s minor drop this week was just about the currency move. Call gold flat this week

And finally, silver fell -1.68%, printed a bearish reversal, but remains (more or less) in an uptrend. At least for now.

So this does support the recession-flation thesis. We’ll have to see how it plays out. Payrolls next week.

News That Caught My Eye

The phrase “Lets Go Brandon” has finally made it into the mainstream media, more than 30 days after it started trending.  Here’s a representative piece:

How ‘Let’s Go Brandon’ became code for insulting Joe Biden

Source

While the reporter lays out the facts, what she appears to miss is that the public’s delight in the phrase was entirely due to the MSM reporter who decided – as is now standard practice – to lie to the public, in real time, in the face of clear evidence to the contrary. Reporter: “Brandon, you also told me (nervous laugh – clearly heard, repeatedly: “Fuck Joe Biden”) as you can hear the chants from the crowd: ‘Lets go, Brandon’”.

Video here – in case you missed it:

https://odysee.com/@Sydewalkclosed:6/let’s-go-brandon-or-f*-joe-biden:3

I don’t blame the on-camera reporter.  After all, the MSM has been able to get away with saying things like “mostly peaceful protests” right in front of video of burning buildings.  For years now.  So why not “Lets Go, Brandon!”  Plus, I do think there was a quiet revolt occurring in the background – the shot kept switching back to the crowd, and the audio clearly picked up the chant.  I don’t think that was accidental.  Not everyone in MSM likes this state of affairs.

But in the MSM ex-post-facto explainer-article, the writer mentioned: “NASCAR and NBC have since taken steps to limit “ambient crowd noise” during interviews, but it was too late — the phrase already had taken off.”  Gotta keep that “ambient crowd noise” down.  Can’t have phrases taking off in this way.  Otherwise a story might inadvertently leak through the censorship blockade, embarrassing the MSM once more.  “Wait.  So not everyone loves inflation, vaccine mandates, chaos at the border, the disaster in Afghanistan, and the ongoing Wealth Transfer to the Oligarchy?”  Nope.  Not everyone.

The popularity of “Lets Go Brandon” is as much about a big chunk of the public delighting in exposing the sustained and egregious media misinformation/propaganda campaign on just about every topic, as it is a statement telling President Grandpa’s handlers where they can stick their mandates.

But of course the MSM must pretend they don’t notice that part.  What must it have been like to work for Joe Goebbels, back in the day?  The MSM now knows exactly what it was like.

This week’s FLCCC weekly update is basically a home-care prepper instruction.  They lay out which mouthwash to buy (and how to construct our own, from iodine), nasal sanitation, dosing for nigella sativa & honey, and curcumin – all designed for jurisdictions where Ivermectin has been declared Verboten by the local Oligarchy/Sickcare stooges who appear to prefer that we get hospitalized, and then possibly die, for reasons known only to themselves.

Given that “hospitalization” translates directly into “No Treatments For You” (other than dexamethasone 6mg and remdesivir-which-doesn’t-work), the quasi-revolutionary goal, obliquely stated by the FLCCC, is “How to Stay Out of the Hospital and Stay Well at Home.”

Left unsaid: “the Oligarchy’s Sickcare System” is absolutely to be avoided, if at all possible.  Fourth Turning Medicine.


How to Stay Out of the Hospital and Stay Well at Home

Source


Evergrande makes coupon payment before Friday deadline -sources

Reuters was not able to determine the source of the funds used to make the interest payments. Bloomberg News reported earlier this week that Chinese authorities had urged Evergrande’s founder, Hui Ka Yan, to pay the developer’s debts out of his personal wealth.

Any prospect of Evergrande’s demise raises questions over the fate of more than 1,300 real estate projects it has ongoing in some 280 cities.

A leaked 2020 document, branded fake by Evergrande but taken seriously by analysts, showed the developer’s liabilities extended to more than 128 banks and over 121 non-banking institutions.

Source

Bwahaha.  The CCP “urged” the founder to pony up the cash.  Don Corleone: “I gave him a ‘suggestion’ that he couldn’t refuse.”

But – 1300 real estate projects ongoing in 280 cities?  And liabilities at 128 banks?  My goodness.  It seems unavoidable that the chickens will eventually come home to roost.  But between now and then, the founder’s bank account might just be depleted a bit more.

In a rare move, CNN accidentally uncovers what is really going on with the bigger picture:

Evergrande wants to build electric cars, not homes

A shift in strategy would also bring Evergrande into alignment with some of Beijing’s biggest priorities.

….earlier this month, the president of the electric vehicle unit, Liu Yongzhuo, said that the company would deliver its first car in early 2022, according to a statement.

As the government cracks down on the property sector, it’s also trying to boost the production of electric vehicles in the world’s largest car market. Beijing has offered subsidies to car manufacturers and buyers, and it wants new energy vehicles to make up 20% of overall new car sales by 2025, from the current level of about 5%.

Source

Let’s leave aside for a moment the likelihood of property-developer Evergrande (which has never actually produced a car) somehow managing to produce, in volume, a functioning electric car by Q1 2022, the profits from which will allegedly allow it to fund those 1300 real estate projects.  Just reading between the lines, we find that the CCP itself popped the property bubble, after doing everything to encourage it to inflate over the last 20 years, the better to inflate China’s GDP.  And almost certainly, to make CCP members rich in the process.

Last year, the CCP woke up and suddenly decided: “property construction is out” (30% of GDP), while: “electric cars are in!”   Should be interesting to see how that turns out.  Did I mention property was 30% of GDP?

“And just like that – it was gone.”

I’m guessing the CCP members sold the top, dumping their “investment properties” for electric car manufacturers.  Chinese Plebes?  I’m guessing they’ll be the bagholders.  Boy does that like a familiar playbook.


NYC: 40 Percent of Inspected Businesses Noncompliant With Vaccine Pass Mandate

NEW YORK CITY—Approximately two in five New York City restaurants, gyms, and entertainment venues weren’t fully abiding by the city’s COVID-19 vaccination pass mandate when first inspected.

Source

Black Lives Matter.  Unless you are black, unvaxxed, and want to go to eat at an NYC restaurant, in which case – “No Soup For You!”  But it does seem as though compliance isn’t exactly 100%.

You know, I bet a “digital vax pass” would work a whole lot better.   Electric shop door won’t open unless the pass is valid.  Gee, I wonder if they’ve thought of that one yet?  Because – Black Lives Matter!


Employers Forced to Raise Wages by Most in at Least 20 Years: Whole Power Balance Has Changed

Source

Wolf goes into great detail about how – for a variety of reasons – labor now has the upper hand.  Is this just about small biz getting crapped on again?

Starbucks was one of the big names with relatively low-wage service workers that came out with an announcement of “unprecedented investments in wages” – because calling it an “investment” sounds a lot better to investors and algos than calling it an “expense,” which is what wages are from an accounting point of view.

Even the banksters are having to pay more money to their bankster-factotums.

Goldman Sachs is in this category. In August, sources told the Wall Street Journal that the base pay for its entry-level first-year analysts in its investment banking division would jump by 29% to $110,000. For its second-year analysts, salaries would jump by 31% to $125,000. For first-year associates, salaries would jump by 20%, to $150,000.

Was this part of the Oligarchy’s Grand Plan?  I don’t think so.  Anything that doesn’t make the Oligarchy richer and more powerful would seem to fall into that pesky “unintended consequences” bucket.

Can we have labor market shortages during a recession?  I think we may be about to find out.


FDA officials praised Pfizer for fighting a virus that is the leading killer of children after cancer, vehicular accidents, suicide, heart disease, drowning, suffocation, the flu, meteors from space, and slipping on a banana peel. Experts say the vaccine will probably kill more kids than it saves, but it’s ok because science. When asked about any safety concerns, an FDA official replied, “We’re excited to start giving it to them so we can find out.”

Source

Babylon Bee has turned into a news site.  When the actions of our captured “health” agencies are this absurdly sociopathic, how far must you go to ridicule them?   Poor Babylon Bee can’t quite seem to do it.  That’s probably why Oligarchy-controlled media feels the need to “fact-check” BB’s attempted-snarky pieces – they look way too much like real news.

The ability of ridicule to impel change reminds me of a fellow named Thomas Nast, who, back in the 1870s, was able – through his political cartoons – to expose and remove a corrupt New York City political figure named Boss Tweed through satire alone.  Towards the end, Boss Tweed feared Nast so much, he offered him a $500,000 bribe in order to support him in “studying art in Europe.”  That was real money back then (500k dollars = 25,000 oz of gold).  Nast declined.  Tweed ended up convicted of fraud.  Nast was a universally-admired heroic figure at one point.  But now?

How it started – election manipulation by Tweed:

How it is going – No Cartoons For You!


Does anyone remember the anti-war ballads from the 1960s?  We are starting to see more of them springing up today.  Dr. McCullough has showcased a number of them in his podcasts.

This week’s podcast here.

Shawn Galloway – Hands Off!

Eric Clapton with Van Morrison – This Has Gotta Stop

The whole “ballad” theme led me on a brief research-adventure – looking up the “antiwar” songs from the 1960s – which the media at the time, in an unsurprising example of history rhyming, was “somewhat averse to playing.”  I imagine if they had YouTube back in the 1960s, these songs would all have been removed due to “Vietnam War Misinformation” due to the Trusted-War-Fighting Initiative.

Today, the “unvaxxed” appear to be playing the role of the initially-very-unpopular counter-culture hippie free-love “draft-dodgers” from the 1960s.

Buffalo Springfield – For What its Worth

Phil Ochs – Draft Dodger Rag

Tom Paxton – Lyndon Johnson Told The Nation

Crosby, Stills, Nash & Young – Ohio

But, for those who served – “the vaxxed” of their time; they did what they thought was the right thing, or what they felt they could not avoid – there are also songs too.  It turns out my uncle served.  Lost a third of his unit KIA/WIA over a 3 month period in 1968.  Came back with PTSD – which we didn’t know about at the time.  I was very young.  But I remember.

Creedence Clearwater Revival – Fortunate Son

The Animals – We Gotta Get Out Of This Place

Both Vietnam-era “served” and “draft-dodger” groups shared more than they knew.  The Oligarchy never had to dodge or serve – just the Plebes.  Listen to “Fortunate Son”, above, as to how that felt to those who served.

As with Vietnam, the “shots in arms” campaign is just Oligarchy crapping on the Plebes once more, but this time, it isn’t just the military-age young men who are being coerced into taking life-and-death risks “just because.”  It is all of us.  And now our children, too.

Vaxxed and unvaxxed – we are all in this together.  And our “antiwar” movement is beginning to take off.  There will be songs for both groups by the end of this story.  And who knows, it may be the songs that move the “emotional” needle to the place it needs to be.

Last: here is the vaccine “booster hamster wheel” in a single picture.  It tells us that the vaxxed are more likely to be infected than the unvaxxed after about 240 days post-vax.

I am left with this question: is this a bug, or is it a feature?


Source

To my vaxxed and unvaxxed friends alike: early treatment saves lives.  FLCCC tells us how.  The (above) chart says: after enough time passes, we really are all in this together.

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21 Comments

  • Sun, Oct 31, 2021 - 4:35pm

    #1

    pinecarr

    Status: Platinum Member

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    Love your commentary, Dave!

    Thank-you!

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  • Sun, Oct 31, 2021 - 4:52pm

    #2
    You've been Nudged...!

    You've been Nudged...!

    Status: Gold Member

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    9

    Black Lives Matter. Unless you are unvaxxed.

    "Black Lives Matter. Unless you are black, unvaxxed, and want to go to eat at an NYC restaurant, in which case – “No Soup For You!”"

    "Experts say the vaccine will probably kill more kids than it saves, but it’s ok because it's science. When asked about any safety concerns, an FDA official replied, “We’re excited to start giving it to them, so we can find out.”"

    And I thought it was all going to be about boring finance....

    Russell Bland also does a good take on 'Let's go Brandon'.





     

     

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  • Mon, Nov 01, 2021 - 12:36am

    #3
    Primary Care_MD

    Primary Care_MD

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    Primary Care_MD said:

    When does the story of Covid begin? Maybe 1971?

    -The WEF was formed (Jan)

    -26th Amendment (Mar)

    -Vietnam protests (April, May)

    -the NYT published the Pentagon Papers (June)

    -Kissinger's secret trip to China (July 9)

    -Nixon closing gold window (Aug 15)

    -the Powell Memo (Aug 23)

    Was 1971 the year when TPTB saw the new field of biotech as the best way to reduce the world's population, and make the deaths appear to be natural? If only they could create a fake pandemic, as an excuse to 'vaccinate' the planet...what Bill Gates called "the final solution"

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  • Mon, Nov 01, 2021 - 3:40am

    Honolulukats

    Honolulukats

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    Honolulukats said:

    This hooking headline is misleading

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  • Mon, Nov 01, 2021 - 4:15am

    #5

    thatchmo

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    thatchmo said:

    Yeah, man.  The Music that kept the flames lit.....Just gotta add:

    Steppenwolf- Monster

    Country Joe McDonald- Feel Like I'm Fixin' to Die rag

    Laura Nyro- Save the Country

    Aloha, Steve

     

     

     

     

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  • Mon, Nov 01, 2021 - 6:42am

    #6
    You've been Nudged...!

    You've been Nudged...!

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    The vaccine will probably kill more kids than it saves

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  • Mon, Nov 01, 2021 - 8:09am

    #7
    hotsauce

    hotsauce

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    hotsauce said:

    China pushing electric vehicles makes sense for a few reasons.

    They know the western powers that be are pushing them, so there is money to be made outside of China if they can get the industry off the ground.

    They do not care about carbon emissions or pollution. I heard that they built more new coal power plants in 2020 than the rest of the world combined. However, electric vehicles allow them to hide that massive air pollution from their cities by displacing it to the plants in outlying areas. Hiding problems from the plebes is standard practice.

    Electric cars also give you more control over people. They have less range, and they need the power grid and a network of charging stations to function. I bet you’ll need your digital ID phone app to pay at a charging station. I guarantee the ability to charge your vehicle will be another thing they will cut off if your social credit score gets too low. No keeping extra cans of gas at home or bartering with friends for them.

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  • Mon, Nov 01, 2021 - 9:39pm

    #8
    Grover

    Grover

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    Notice Of Price Increases

    I just got an e-mail from a supplier of products I use to warn of significant price increases. I'm afraid that this won't be the last notice before the Fed's "transitory inflation" stops. This is the meat of the letter. I've bolded the portions that I consider most significant.

    Most of our products will see an increase of 8-12%. However, there may be a few outliers that fall outside of this range. There are a handful of input cost increases in particular that have driven the need for a price increase at this time:

    • Obviously, [our products] are made of steel, which has always been our highest cost. In many cases, our steel costs have increased more than 30% this year alone. An increase of this magnitude has never been seen in the industry.
    • Our second-highest cost is labor. Businesses across the country are struggling to attract and retain employees. The war for talent has never been more fierce. Naturally, this has led to higher wages.
    • Aside from steel and labor, our other input costs have continued to rise at historic rates as well. This includes the cost of coolant, safety supplies, abrasives, and other necessary items. In fact, the cost of our corrugated packaging supplies has doubled in the last 18 months.

    Again, we would like to stress that the magnitude of these cost increases has never been seen in our 75-year history.

    I realize that getting a price increase notification is never pleasant. However, I do want to emphasize that [redacted company] is not using this as an opportunity to increase our profit margin. The reality of the situation is that [redacted company] is absorbing more of these input cost increases than we are passing along.

    Imagine getting this letter ... knowing that you'll have to pass the costs to your customers. You may understand the reasons behind these cost increases, but your business will suffer somewhat regardless. Only the Fed wants inflation.

    Grover

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  • Tue, Nov 02, 2021 - 9:34am

    RandomMike

    RandomMike

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    Electric vehicles = Electric power/travel tracking

    Just a minor point, but when you have an electrical vehicle, you get your power from the electric power company (probably, unless you have solar or fuel generator). And your power use is tracked and will be able to be controlled.  As in for an extreme example: no vax, no power, no go.

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  • Tue, Nov 02, 2021 - 9:51am

    DaveDD

    DaveDD

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    DaveDD said:

    Interesting question that I was thinking about recently. You might be right about the year. I remembered that when I was four years old, 1972, I was sitting on a chair while my mother treated a scratch on my knee. The radio was on, and I remember vividly that they were talking about the leaked, new Club of Rome report. On the radio they discussed the impact of overpopulation on the Earth resources.

    I asked my mother "but why don't they just kill some people then?", her aswer was "Dave, that is a good idea, let's start with you OK?"

    This really happened, and somehow I realized that it kind of formed me. But nowadays I think that the thought that I had as a four year old child, is actually the thought some grown-ups have. Grown-ups that weren't blessed with a mother as wise as mine.

    Btw, the reason why I remember this is that I had a rather traumatizing experiences when I was two, I kind of remember events from that age on.

     

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  • Tue, Nov 02, 2021 - 10:34am

    2retired

    2retired

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    2retired said:

    That kind of 'plain speak' with no ill intent used to be the norm, now people complain about 'triggers', sensitivities (another tread), and off side humour! I remember quote from a book about humour, that said 'to be funny, you have to offend someone'. I remember being told 'go bleed outside'; I tell it as much for how people react, as a story about common sense over coddling (there was no ill intent meant or received) by my mother, just exasperation (I think) at the constant demands and mess that I created and was in to.

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  • Tue, Nov 02, 2021 - 11:58am

    #12
    davefairtex

    davefairtex

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    no vaccine, no candy (#2)

    An amusing-but-topical cartoon, h/t automatic earth.  Multi-layered.  🙂

    https://www.theautomaticearth.com/2021/11/debt-rattle-november-1-2021/

    Amusing addendum.  I posted this to facebook, only to have it labeled with the following:

    "Let's go, facebook!"

    [Had to repost this.  Editing my previous post removed the cartoon, and I couldn't put it back.  (sigh)]

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  • Tue, Nov 02, 2021 - 12:15pm

    #13

    thc0655

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    No Halloween. No candy. It’s not safe.

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  • Tue, Nov 02, 2021 - 12:42pm

    DaveDD

    DaveDD

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    DaveDD said:

    This is so funny. Thanks for the laugh!

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  • Tue, Nov 02, 2021 - 12:52pm

    #15
    sand_kitty

    sand_kitty

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    Bitcoin at all time high

    I have come to believe that the bitcoin transformation is real.  It is a real change in where money comes from and how it works.

    Quite a few indicators of wider adoption and greater acceptance by TPTB.

    Peter Theil remarked that he wished he had gotten on the bitcoin train earlier.

    More regulatory acceptance statements.

    More institutions shifting cash into bitcoin.

    I am a participant out of desire to earn money (so I can buy a house and retire) and to change the way that money works so that the oligarchy doesn't hold the printing press.

    The buying of everything by Blackrock and Vanguard is closely related to the oligarchy's control of money printing.  I pray that bitcoin can stop this.

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  • Tue, Nov 02, 2021 - 9:37pm

    #16
    davefairtex

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    FWIW: FOMC policy annoucement tomorrow. Powell @ 14:30 Eastern

    Related: Powell's term is up in February.  President Grandpa's handlers are hinting they might replace him:

    https://thehill.com/policy/finance/579699-biden-says-hell-announce-fed-picks-fairly-quickly

    “I’ve given a lot of thought to it and I've been meeting with my economic advisors on what the best choices are. We've got a lot of good choices, but I’m not going to speculate now,” Biden said.

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  • Wed, Nov 03, 2021 - 10:58am

    #17
    davefairtex

    davefairtex

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    Rumble moves its HQ to Florida!

    https://www.heraldtribune.com/story/news/local/2021/11/02/toronto-based-rumble-moving-headquarters-longboat-key-florida/6246988001/

    MSM is desperate to drop rumble into a "conservative platform" box, in order to keep any (old-style) liberals who want to exercise things like free speech or wander outside the narrative.  Greenwald has a "system update" channel on Rumble.

    He's not-exactly-conservative.  🙂

    https://twitter.com/ggreenwald/status/1455587545807470602

    I'm not saying this is the reason for their move -- I don't know it -- but I do know Canada, where Rumble has been based since 2013, is actively creating laws to impose civil or even criminal liability on social media platforms that don't censor enough. The UK is doing the same:

    It looks like Rumble will soon be free of the censorship threats from formerly-free-Canada.

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  • Wed, Nov 03, 2021 - 12:19pm

    #18
    Chris Martenson

    Chris Martenson

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    Rumble moves!

    It looks like Rumble will soon be free of the censorship threats from formerly-free-Canada.

    I am actively looking for a home for a new aggregated news network of sorts, and I had written off Rumble because it was homed in Canada, which is out-communisting China.

    This puts them back into the game.

    Thanks for posting.

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  • Wed, Nov 03, 2021 - 12:43pm

    Canuckian

    Canuckian

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    Canuckian said:

    out-communisting China

    Haha...good one Chris! So ashamed of my country right now. Thanks for nothing Klaus Trudeau!

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  • Fri, Nov 05, 2021 - 1:53pm

    #20
    davefairtex

    davefairtex

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    payrolls, the strike, and the pfizer pill

    Headline PAYEMS +531k.  Relatively positive.

    Equities rallied through 10am on the news, but are now selling off.

    Remember: nationwide strike planned for Nov 8th - that's Monday.  Will the captured media bill this as "weather" or "supply chain problems"?  Or will the actual news leak out?

    When the media lies so often and so predictably, the "market surprises" will be larger and more shocking when the real events hit - since most people won't be warned in advance.

    And in other news: MRNA and BNTX were both crushed today: MRNA: -21%, BNTX: -20.6%.

    Perhaps it was Pfizer's new pill, which will no doubt fix literally everything and work flawlessly.  When combined with Ritonavir.

    "Highly effective."  No pre-print, just a press release.

    https://www.pfizer.com/news/press-release/press-release-detail/pfizers-novel-covid-19-oral-antiviral-treatment-candidate

    Wonder what that will do to the "mandate" narrative?

    https://clinicaltrials.gov/ct2/show/NCT04960202

    The "Exclusions" is an interesting section:

    History of or need for hospitalization for the medical treatment of COVID-19
    Prior to current disease episode, any confirmed SARS-CoV-2 infection
    Known medical history of active liver disease
    Receiving dialysis or have known moderate to severe renal impairment
    Known human immunodeficiency virus (HIV) infection with a viral load greater than 400 copies/mL or taking prohibited medications for HIV treatment
    Suspected or confirmed concurrent active systemic infection other than COVID-19
    History of hypersensitivity or other contraindication to any of the components of the study intervention
    Current or expected use of any medications or substances that are highly dependent on CYP3A4 for clearance or are strong inducers of CYP3A4
    Has received or is expected to receive convalescent COVID-19 plasma
    Has received or is expected to receive any dose of a SARS-CoV-2 vaccine before the Day 34 visit
    Participating in another interventional clinical study with an investigational compound or device, including those for COVID-19 through the long-term follow-up visit
    Known prior participation in this trial or other trial involving PF-07321332
    Oxygen saturation of <92% on room air, or on their standard home oxygen supplementation for those who regularly receive chronic supplementary oxygen for an underlying lung condition
    Females who are pregnant or breastfeeding

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  • Fri, Nov 05, 2021 - 4:56pm

    Kathy

    Kathy

    Status: Gold Member

    Joined: Feb 21 2020

    Posts: 632

    2

    So all of these?

    Current or expected use of any medications or substances that are highly dependent on CYP3A4 for clearance or are strong inducers of CYP3A4

    I may be wrong CYPA3/4 may be something different then CYP3A4.

    If I am not wrong, we could end up with a lot of mentally ill high schoolers losing it because the antidepressant prescribed to them 6 months ago isn’t clearing at an expected rate.

    CYP 3A3/4

    Analgesics—acetaminophen, alfentanil, codeine, dextromethorphan Antiarrhythmics—amiodarone, disopyramide, lidocaine, propafenone, quinidine
    Anticonvulsants—carbamazepine, ethosuximde
    Antidepressants—amitriptyline, clomipramine, imipramine, nefazodone, sertraline, O-desmethylvenlafaxine Antiestrogens—docetaxel, paclitaxel, tamoxifen
    Antihistamines—astemizole, loratadine, terfenadine
    Antipsychotics
    —clozapine Benzodiazepines—alprazolam, clonazepam, diazepam, midazolam, triazolam
    Calcium Channel Blockers—diltiazem, felodipine, nicardipine, nifedipine, niludipine, minodipine, nisoldipine, nitrendipine, verapamil Immunosuppressants—cyclosporine, tacrolimus (FK506—macrolide)
    Local Anesthetics—cocaine, lidocaine Macrolide Antibiotics—clarithromycin, erythromycin, triacetyloleandomycin Steroids—androstendione, cortisol, dihydroepiandrosterone 3-sulfate, dexamethasone, estradiol, ethinylestradiol, progesterone, testosterone Miscellaneous—benzphetamine, cisapride, dapsone, lovastatin, omeprazole (sulfonation)

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