Why are they scared of vitamin D?
That’s great stuff on Mg, thanks for that. Ran out and got some just today.
So all the caveats are probably right.
At the same time, the study showed that the risk of cancer dropped, for those who got a Vit-D supplement, even though – all of what you said is no doubt true.
Now just imagine if we got the set of supplements right?
And yes if our diets were great, and the minerals were still in the soil (rather than being depleted by our current farming methods) and if we went outside enough (unlike me, who tends to sit in my office for way, way too long) – say we were still hunter-gatherers – then none of us would need anything. That’s the “A” answer.
Short of that, the “B” answer would seem to be supplementation. It certainly seems better than just doing nothing.
I mean, that’s how I see it anyway.
And I should probably get outside more. 🙂
We have light sensors throughout our body. The “opsins”. Like melanopsin. You don’t want to burn but you should aim for as much direct sunlight as you can across as much of the day as possible because the mix of wavelengths changes throughout the day. The changing mix manages much of your hormonal system. It’s so much more than just making natural Vitamin D. Similarly, you want to avoid screwing it up by artificial light after sunset, especially blue light. For instance, the melatonin precursor you make before sunset will be destroyed by nighttime blue light. Stick to as much of a natural circadian rhythm as you can. You can develop a solar “calus” by lots of light early and late in the day and that will help protect from burns. On average, the incidence of melanoma goes DOWN with more sunlight exposure, provided you don’t burn and you’re aiming for regular exposure opportunities.
Doctors aren’t good at physics so they tend to ignore biophysics. They’re missing out on so much of the picture. To a large degree it has to do with promoting mitochondrial health.
Re: the JAOA article link, this source worked for me.
And why is it, exactly, that Bill G wants to dim the sun?
I am blood type B. Years ago, I read that B blood types have a hard time absorbing magnesium. So I have been supplementing Mg. Magnesium L-Threonate is a superior form, able to cross the blood-brain barrier.
Older people have issues with creating enough Vit. D precursors from the sun. I get tested through a home test kit from Grassroots Health. Dr. Mercola has for a long time been pushing people to get tested and increase their Vit. D. When I moved from Seattle ten years ago, I tested at less than 20ng/ml. I have been working on this and my test last fall was 67ng/ml.
I now have such a large supplement stack, it gets kind of tedious to get everything down. But I do some in food. Luckily I find, some of the anti-covid things overlap with my longevity choices.
Thank you, Dave and everyone for the good information.
I have been taking 30K IU of D3 for two months on a recommendation of my doctor who used to be head of Emergency Medicine and Preventative Medicine at major hospitals before he left and founded his own private clinic (educated at Johns Hopkins). Dosing D3 h is logarithmic so when you get to high end you don’t absorb as much but daily supplement provides for immediate need especially if you have chronic illness.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220998/ is a study with a title in need of a diet: “The Importance of Body Weight for the Dose Response Relationship of Oral Vitamin D Supplementation and Serum 25-Hydroxyvitamin D in Healthy Volunteers”
Hopefully when I try to paste Figure 1, it will appear correctly:
The dose response relationship between oral vitamin D supplementation and serum 25(OH)D levels based on 22,214 observations of healthy volunteers.Footnote: Bubbles represent the mean plasma 25(OH)D level for all reported daily doses. The size of the bubbles is proportional to the number of assessments for each of the reported daily doses. The red line represents the fitted dose response curve.
Figure 3 shows how that relationship varies according to weight:
From the discussion section:
Furthermore, this study provides detailed recommendations for supplementation to achieve 25(OH)D targets specific for normal weight, overweight and obese individuals (provided in Table 4). These recommendations appeared 2 to 3 times higher for obese participants relative to normal weight subjects, depending on the 25(OH)D target level.
This could explain the original poster’s study which did not show a cancer benefit from Vitamin D supplementation for the overweight and obese. These individuals require 2 to 3 times as much Vitamin D to have a beneficial effect because much of the supplement gets stored in the fat tissue.
I appreciate this thread. I work with an incredible MD/herbalist who wants all of her clients to have a blood level of Vitamin D above 50ng/ml. This is higher than the 20-50ng/ml range recommended. For bioavailability she recommends liquid vitamin D. I must say that I feel dramatically better now that my Vitamin D level is above 50ng/ml.
There is no money in people being healthy……
Thanks Dave for your good summary for Vit D and others for discussion. Good to know about vit A and K for higher D.
In my research, ran across some links which suggest that for a long time there has been a huge under-recommendation on doses of Vit D, perhaps from a mistake, or ???
By about 10X !!!!
Suggestion of mistake made in recommended supplementation here:
refers to this article
Also, notice below how high the safe limit is on Vit D in the blood, and how high above that is the “toxic” level.
Sufficient: 20–30 ng/ml, or 50–75 nmol/L.
Safe upper limit: 60 ng/ml, or 150 nmol/L.
Toxic: Above 150 ng/mL, or 375 nmol/L.
I was told by Dr. DeMello in India who claims to treat 1000’s of folks prophylacticly for Covid, to take 10,000 IU per day, attempt to get between 60 and 100 ng/mL and get tested. I was recently tested after a few months of this dose and came in at 70 ng/mL. I know I probably have to adjust with more insolation at 40degrees in April through Sept.
My own (mostly ignorant about alternative Covid treatments) suggested between 20 to 30 ng/mL is fine. I do notice that the 30 number seems to provide pretty good outcomes in Covid, referenced here:
And one excerpt, addressing other benefits.
Additional benefits of vitamin D. Studies have shown that a high intake of vitamin D reduces risk of respiratory tract infections , stroke , multiple sclerosis , rheumatoid arthritis , type 2 diabetes , breast cancer , prostate cancer , colon cancer , and all-cause mortality . Severe vitamin D deficiency more than doubles risk of death from cancer in-hospital, and more than triples death from cancer after one year .