What studies are available on D vitamin and Covid?
At the Convention Chris linked to a medical journal showing that D vitamin did help lower mortality in Covid.
Do you know of other studies showing the same?
I am butting heads with the government in Denmark in the quest for an answer to why this is not used.
Here are three studies that Chris has referenced at some point:
Here’s one Dr. John Cambell referenced:
and the one mentioned on MedCram:
P.S. Minks, among others, sure are having a tough time in Denmark…
Thank you so much for compiling the Vita D links, lastfirst.
Thanks a lot!
Here is a very dramatic chart showing the relationship between severe Covid-19 and lack of Vitamin D:
One of the latest studies on vitamin D and COVID-19, published by Castillo et al., enrolled 76 COVID-19 patients hospitalized with symptoms of acute respiratory infection and randomized them to the vitamin D treatment group (n=50) or the control group (n=26). There were 45 men and 31 women with an average age of 53 years. Their goal was to determine if early intervention with 25(OH)D, the metabolite of vitamin D used to measure vitamin D status, could improve outcomes of COVID-19 and reduce the need for Intensive Care Unit (ICU) admission.
Both groups received the standard care for COVID-19, consisting of a combination treatment of hydroxychloroquine and azithromycin, with additional standard treatments as necessary. The vitamin D treatment group also received a .532 mg dose of oral calcifediol (25(OH)D) at admission, followed by .266 mg doses on days 3 and 7, and then once weekly until either discharged or admitted to the ICU. Calcifediol, or 25-hydroxyvitamin D3, was given due to its reliable intestinal absorption and to omit the need for hydroxylation of vitamin D3 to 25(OH)D in the liver, therefore leading to a more rapid improvement in 25(OH)D levels and availability.
What were the outcomes of this study?
The study found that the administration of 25(OH)D at the early stages of COVID-19 significantly reduced the need for admission to the ICU, regardless of existing comorbidities, as illustrated in the chart below.
It looks like the initial dose of calciferdiol given in the article above was 500 mg, equivalent to about 15,000 IU. Then they repeated half that dose again on days 3 and 7.
Calcifediol, or 25-hydroxyvitamin D3, was given [orally] due to its reliable intestinal absorption and to omit the need for hydroxylation of vitamin D3 to 25(OH)D in the liver, therefore leading to a more rapid improvement in 25(OH)D levels and availability.
There is a . before the number. I read it as 0,5 mg or 500 mcg as first dosage.
In Denmark the recommended daily dosage is 10 mcg.
The dosage they used was 50 times that.
Thanks lastfirst for the list!
Also one more:
This is the Spanish study (80% of hosp patients had low Vit D) in news form:
Here it is in science form:
Here’s another one, hot off the presses (10/30/20). Small, but significant:
Reading through the above reports and looking at references, I came across this study.
One conclusion seemed to be that Vitamin D had no effect when other factors are taken into account.
I do not fully understand all the details, but would anybody care to comment on the validity of the details or otherwise?