What studies are available on D vitamin and Covid?

Login or register to post comments Last Post 0 reads   12 posts
Viewing 10 posts - 1 through 10 (of 12 total)
  • Thu, Oct 29, 2020 - 09:37am

    #1
    Lars Lottrup

    Lars Lottrup

    Status Member (Offline)

    Joined: Sep 23 2020

    Posts: 6

    count placeholder1

    What studies are available on D vitamin and Covid?

At the Convention Chris linked to a medical journal showing that D vitamin did help lower mortality in Covid.

Do you know of other studies showing the same?

 

I am butting heads with the government in Denmark in the quest for an answer to why this is not used.

  • Thu, Oct 29, 2020 - 10:01am

    #2
    lastfirst

    lastfirst

    Status Member (Offline)

    Joined: Oct 17 2020

    Posts: 3

    count placeholder4

    Reply To: What studies are available on D vitamin and Covid?

Lars,

Here are three studies that Chris has referenced at some point:
https://www.sciencedirect.com/science/article/pii/S0960076020302764
https://www.sciencedirect.com/science/article/pii/S096007602030296X
https://www.medrxiv.org/content/10.1101/2020.09.04.20188268v1.full.pdf

Here’s one Dr. John Cambell referenced:
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2770157

and the one mentioned on MedCram:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0239252

Cheers!

P.S. Minks, among others, sure are having a tough time in Denmark…

  • Thu, Oct 29, 2020 - 11:37am

    #3

    sand_puppy

    Status Platinum Member (Offline)

    Joined: Apr 13 2011

    Posts: 2476

    count placeholder1

    What studies are available on D vitamin and Covid?

Thank you so much for compiling the Vita D links, lastfirst.

  • Thu, Oct 29, 2020 - 01:50pm

    #4
    Lars Lottrup

    Lars Lottrup

    Status Member (Offline)

    Joined: Sep 23 2020

    Posts: 6

    count placeholder0

    What studies are available on D vitamin and Covid?

Thanks a lot!

  • Thu, Oct 29, 2020 - 02:02pm

    #5

    gallantfarms

    Status Bronze Member (Offline)

    Joined: Jun 18 2009

    Posts: 70

    count placeholder3

    Some Dramatic Charts on Vitamin D & Covid-19

Here is a very dramatic chart showing the relationship between severe Covid-19 and lack of Vitamin D:

———————————–

Another study:

Vitamin D Treatment for COVID-19 Patients Nearly Erased Need for ICU Admission

One of the latest studies on vitamin D and COVID-19, published by Castillo et al., enrolled 76 COVID-19 patients hospitalized with symptoms of acute respiratory infection and randomized them to the vitamin D treatment group (n=50) or the control group (n=26). There were 45 men and 31 women with an average age of 53 years. Their goal was to determine if early intervention with 25(OH)D, the metabolite of vitamin D used to measure vitamin D status, could improve outcomes of COVID-19 and reduce the need for Intensive Care Unit (ICU) admission.

Both groups received the standard care for COVID-19, consisting of a combination treatment of hydroxychloroquine and azithromycin, with additional standard treatments as necessary. The vitamin D treatment group also received a .532 mg dose of oral calcifediol (25(OH)D) at admission, followed by .266 mg doses on days 3 and 7, and then once weekly until either discharged or admitted to the ICU. Calcifediol, or 25-hydroxyvitamin D3, was given due to its reliable intestinal absorption and to omit the need for hydroxylation of vitamin D3 to 25(OH)D in the liver, therefore leading to a more rapid improvement in 25(OH)D levels and availability.

What were the outcomes of this study?
The study found that the administration of 25(OH)D at the early stages of COVID-19 significantly reduced the need for admission to the ICU, regardless of existing comorbidities, as illustrated in the chart below.

  • Thu, Oct 29, 2020 - 10:22pm

    #6

    sand_puppy

    Status Platinum Member (Offline)

    Joined: Apr 13 2011

    Posts: 2476

    count placeholder0

    What studies are available on D vitamin and Covid?

It looks like the initial dose of calciferdiol given in the article above was 500 mg, equivalent to about 15,000 IU.   Then they repeated half that dose again on days 3 and 7.

Calcifediol, or 25-hydroxyvitamin D3, was given [orally] due to its reliable intestinal absorption and to omit the need for hydroxylation of vitamin D3 to 25(OH)D in the liver, therefore leading to a more rapid improvement in 25(OH)D levels and availability.

  • Fri, Oct 30, 2020 - 05:01am

    #7
    Lars Lottrup

    Lars Lottrup

    Status Member (Offline)

    Joined: Sep 23 2020

    Posts: 6

    count placeholder0

    What studies are available on D vitamin and Covid?

@sand_puppy
There is a . before the number. I read it as 0,5 mg or 500 mcg as first dosage.

In Denmark the recommended daily dosage is 10 mcg.

The dosage they used was 50 times that.

  • Fri, Oct 30, 2020 - 05:32am

    #8
    Chris Martenson

    Chris Martenson

    Status Platinum Member (Offline)

    Joined: Jun 07 2007

    Posts: 5448

    count placeholder2

    What studies are available on D vitamin and Covid?

Thanks lastfirst for the list!

Also one more:

This is the Spanish study (80% of hosp patients had low Vit D) in news form:

Over 80% of Hospitalized COVID-19 Patients Have Vitamin D Deficiency, Study Finds

Here it is in science form:

https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgaa733/5934827

 

 

  • Fri, Oct 30, 2020 - 08:39am

    #9
    Chris Martenson

    Chris Martenson

    Status Platinum Member (Offline)

    Joined: Jun 07 2007

    Posts: 5448

    count placeholder2

    One more study on D vitamin and Covid?

Here’s another one, hot off the presses (10/30/20).  Small, but significant:

https://link.springer.com/article/10.1007/s00394-020-02411-0

  • Sat, Oct 31, 2020 - 03:43am

    #10
    RPSTemple

    RPSTemple

    Status Member (Offline)

    Joined: Jan 24 2012

    Posts: 28

    count placeholder0

    Vitamin D and Covid? A confounding report?

Reading through the above reports and looking at references, I came across this study.

https://www.sciencedirect.com/science/article/pii/S1871402120301156

One conclusion seemed to be that Vitamin D had no effect when other factors are taken into account.

I do not fully understand all the details, but would anybody care to comment on the validity of the details or otherwise?

Viewing 10 posts - 1 through 10 (of 12 total)

Login or Register to post comments