What is the ultimate prophylactic cocktail? A thread to collect evidence
Niacin… is there anything it can’t do? It’s potential usefulness as an adjunct to Covid-19 prophylaxis has been covered previously in this thread.
The incidence of overweight and obesity has become a global public health problem, constituting a major risk factor for numerous comorbidities. Despite tremendous efforts, effective pharmacological agents for the treatment of obesity are still limited. Here, we showed that in contrast to lactate receptor GPR81, niacin receptor GPR109A-deficient mice had progressive weight gain and hepatic fat accumulation. Using high-fat diet–induced mouse model of obesity, we demonstrated that niacin treatment apparently protected against obesity without affecting food intake in wild-type mice but not in GPR109A-deficient mice. Further investigation showed that niacin treatment led to a remarkable inhibition of hepatic de novo lipogenesis. Additionally, we demonstrated that niacin treatment triggered brown adipose tissue and/or white adipose tissue thermogenic activity via activation of GPR109A. Moreover, we observed that mice exposed to niacin exhibited a dramatic decrease in intestinal absorption of sterols and fatty acids. Taken together, our findings demonstrate that acting on GPR109A, niacin shows the potential to maintain energy homeostasis through multipathways, representing a potential approach to the treatment of obesity, diabetes and cardiovascular disease.—Ye, L., Cao, Z., Lai, X., Wang, W., Guo, Z., Yan, L., Wang, Y., Shi, Y., Zhou, N. Niacin fine-tunes energy homeostasis through canonical GPR109A signaling. FASEB J. 33, 4765–4779 (2019). http://www.fasebj.org
A broader perspective on nutrition may be a good approach. I submitted the study link from this article for PP to use in the daily digest, but, so far, it hasn’t made the cut.
Peak Prosperity shares societies reluctance to delve into nutrition science.
Did you know that the food industry is currently using the same consultant once used by the tobacco industry (Exponent Inc.), to counter any damaging science? In addition to tobacco, Exponent has defended things like lead, mercury and asbestos, to name just a few.
Exponent Inc. is very good at confusing fields of science, muddying the water, if you will, to delay or stop shifts in consumption.
He is now arguing against, for instance, withholding IVM until first symptoms. I have not yet decided to employ regular IVM on top of all the supplements.. but I am open to reconsidering. Adam’s argument is the danger of neurological complications from spike protein…
With revelations about spike causing various manners of protein aggregation, both virus and shot, I am changing my stance on early treatment/prophylaxis.
Early treatment entails significant risk of long-term neurodegenerative illness and/or cancers.
Prophylaxis is the only way.
— Adam Gaertner 🇺🇸🇺🇸🇺🇸 (@veryvirology) June 20, 2021
If you click on that link, and read some posts he has made and retweeted around it, we also find that he is extremely concerned about the spike protein doing prion-like folding in the brain. He also tweets about the spike protein in people’s urine entering the water system and being toxic to tadpoles. And the vax’d shedding the spike protein in homes, at the grocery store, etc. Weekly IVM for a decade? as someone asked. Pretty scary reading for a Sunday evening. All in his tweets today Sun 20 accessible via the link Jim H gives.
Remember, the more antiviral weapons, with different mechanisms of action, the more effective our individual prophylactic cocktails become. This one looks to be a very good add…
Antiviral and immunomodulatory activity of curcumin: A case for prophylactic therapy for COVID-19
This review presents several lines of evidence, which suggest curcumin as a promising prophylactic, therapeutic candidate for COVID-19. First, curcumin exerts antiviral activity against many types of enveloped viruses, including SARS-CoV-2, by multiple mechanisms: direct interaction with viral membrane proteins; disruption of the viral envelope; inhibition of viral proteases; induce host antiviral responses. Second, curcumin protects from lethal pneumonia and ARDS via targeting NF-κB, inflammasome, IL-6 trans signal, and HMGB1 pathways. Third, curcumin is safe and well-tolerated in both healthy and diseased human subjects. In conclusion, accumulated evidence indicates that curcumin may be a potential prophylactic therapeutic for COVID-19 in the clinic and public health settings.
There are 4 studies of curcumin in Covid19 now, including 3 double-blind randomized controlled trials.
And the results are quite remarkable: pic.twitter.com/AQ67zG28Kd
— Covid19Crusher (@Covid19Crusher) June 24, 2021
With regard to the food industry, a report from Mercola re how glysophate helps the vaxxines ravage your body:
From Mercola and Sephanie Seneff. Too many good points for excerpts… a good read that connects yet more dots.
I’ve been meaning to post this. A man called Saikat Basu, who is Assistant Professor of Mechanical Engineering at South Dakota State University, has studied the optimal angle for applying nasal sprays for optimal effect. He concludes that it is not the 90 degree upright angle as recommended in most nasal spray leaflets but more like a 45 degree angle so you get more spray on the key areas in the back of your sinuses. It’s horribly complex 3D mathematics. But he says it makes a huge difference in efficacy. There was a simplified version on LinkedIn recently but it’s disappeared (I have the PDF). Otherwise here is a more complex version if you really want the science:
Here is an excerpt from the PDF which I would be happy to forward to anyone interested:
The first site of infection in your body for SARS-CoV-2 is likely the nasopharynx. This is the spot all the way back in the nasal cavity where they stick those long COVID test swabs. Think of the part of your upper respiratory tract where the two sides of your nose meet. Starting from around there, if we go down 4-5 cm along the intranasal tract – that region is the nasopharynx, illustrated in red in Figure 2 (showing the CT scan-based anatomic geometry). The nasopharynx has ciliated epithelial cells rich in the protein (ACE2) that the virus latches on to in order to infect cells…
My question for you all is this: What can we unvaxxed do to protect ourselves from shedding from our vaxxed family, spouses and friends? I have not seen any definitive info yet, correct me if it is out there, about how long most people shed after getting the shot…and the upcoming boosters. How likely am I to bring the spikes into my body from members of my household, and how can I know if I am facing a damaging level of intake? What can I do to protect myself from absorbing them, and also to fight and eliminate them if I take them on?
For me, now, with IVM on board and all of the preventative supplements and practices, I am not concerned about the virus itself or it’s variants. I am concerned about being damaged by my loved ones spike shedding. My husband has had both Moderna shots, as has his niece who lives with us. His parents and sister plan to spend a week with us over Christmas. I will be surrounded by them, all likely with fresh boosters in their arms. Will I need to check into a hotel for that week?
Finally, how likely do you all think it is that boosters will be offered and encouraged this fall, with all of the new info coming out about damage from the vaccines? There is no way that any of these relatives will listen to a single word about the dangers they are bringing upon themselves and those around them. Nor will their personal physicians. Thanks! I appreciate so much hearing your views.
What can we unvaxxed do to protect ourselves from shedding from our vaxxed family, spouses and friends? I have not seen any definitive info yet, correct me if it is out there, about how long most people shed after getting the shot…and the upcoming boosters. How likely am I to bring the spikes into my body from members of my household, and how can I know if I am facing a damaging level of intake? What can I do to protect myself from absorbing them, and also to fight and eliminate them if I take them on?
Here’s my two cents.
No idea how long this will last. A guess: maybe 2-4 weeks, with a peak week #1? Just a guess.
The spike protein – the lab-leak protein, as well as the fake one produced by the shot – causes some people to have a hypersensitivity reaction to this protein. Our bodies just don’t like it. “OMG get this outta here!” This reaction by our bodies generates a histamine release, which ends up causing all sorts of trouble. Like an allergy.
From that Spanish nursing home study, we have some hints that the hypersensitivity reaction to these evil spike proteins can be ameliorated by antihistamines – H1 blockers. So – gun to my head – if I were going to spend an extended period of time with a bunch of relatively newly-vaxxed people, I’d maybe take some (say) claritin ahead of time – after checking first to make sure there were no claritin-drug interactions with anything I was taking currently.
It doesn’t mean the spike proteins won’t get into my system, but it would mean that my body won’t be freaking out when it detected them. My mast cells will still release histamine, but the blocked receptors means my cells won’t go nuts when the histamine release happens. Current best guess: it’s the freak-out that causes the trouble. For the most part. Certainly the nursing home residents that got the antihistamines all survived.
My assumption is, the body wouldn’t take more than a few days to break down these spike proteins – they “hopefully” won’t stick around for too long. Of course, we don’t know this for sure. So all I can do is guess.
Another option – much less evidence for this – niacinamide might help suppress the histamine release from the mast cells. And niacinamide is a NAD+ precursor (great for stress release), as well as a possible prophylaxis for dementia.
I’d try the niacinamide first, and if I started getting annoying spike-protein-exposure hypersensitivity reaction symptoms, I’d deploy the claritin. And if those two things didn’t seem to help, I’d flee and work on plan B.
Friend of mine (n=1) got a “shingles outbreak” after hanging out with a newly-vaxxed individual. My friend never had shingles before – he didn’t even know what shingles was (nor did I!) – friend is young (20-something), athletic, and healthy. I’m really beginning to think shedding really is a thing. Concept being – the hypersensitivity reaction ends up reactivating any latent viruses that happen to be in the body. Like from that childhood smallpox vaccination you got when you were a baby.