What is the ultimate prophylactic cocktail? A thread to collect evidence

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  • Wed, Jun 02, 2021 - 01:02am


    Jim H

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    Mushroom products that are anti-viral and immune boosting

I want to get back to this thread… lots to add.  One of the very first therapeutics that I heard about in the first days of Covid-19 was Chaga mushroom… which if you have not seen it before in nature is kind of an ugly big wart that grows on certain trees in certain regions.  Mr wacky woo woo himself, Clif High, heard from a naturopathic doctor friend at ground zero in Wuhan China that his older patients who were using formulations containing Chaga mushroom had been spared.  A younger patient whose formulation did not contain Chaga had died.  I looked into it a bit, noted that there was a history of Chaga as being anti-cancer, and antiviral, and I ordered a bunch from a purveyor in Northern Michigan.

If you happen to listen to Bix Weir’s Silver youtube podcasts, he will often be sipping a cup of Chaga tea.. I believe he got this idea from Clif as well but not sure.  The idea is simple.. take the dried powder, and make tea out of it.  I have grown very fond of it.. of course you can mix it with other teas too.

Anyway, I have many mushroom pill formulations in my arsenal – mostly Stamet’s Host Defense brand, but Chaga was the one I was originally drawn to and the only one I make tea out of.  It is also an ingredient in some of the Stamet’s multi-mushroom formulations and I will cover these in a later post.

The following was published this year in the International Journal of Medicinal Mushrooms… so it post-dates my gamble on Chaga;


Medicinal Mushrooms against Influenza Viruses

This review provides results obtained by scientists from different countries on the antiviral activity of medicinal mushrooms against influenza viruses that can cause pandemics. Currently, the search for antiviral compounds is relevant in connection with the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Medicinal mushrooms contain biologically active compounds (polysaccharides, proteins, terpenes, melanins, etc.) that exhibit an antiviral effect. The authors present the work carried out at the State Research Center of Virology and Biotechnology Vector in Russia, whose mission is to protect the population from biological threats. The research center possesses a collection of numerous pathogenic viruses, which allowed screening of water extracts, polysaccharides, and melanins from fruit bodies and fungal cultures. The results of investigations on different subtypes of influenza virus are presented, and special attention is paid to Inonotus obliquus (chaga mushroom). Compounds produced from this mushroom are characterized by the widest range of antiviral activity. Comparative data are presented on the antiviral activity of melanin from natural I. obliquus and submerged biomass of an effective strain isolated in culture against the pandemic strain of influenza virus A/California/07/09 (H1N1 pdm09).

  • Wed, Jun 02, 2021 - 03:21pm



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    Listerine mouthwash

I gargle every day with Listerine (cool mint) for 30 seconds.

“Common over-the-counter nasal rinses and mouthwashes/gargles were tested for their ability to inactivate high concentrations of HCoV using contact times of 30 s, 1 min, and 2 min. Reductions in titers were measured by using the tissue culture infectious dose 50 (TCID50) assay. A 1% baby shampoo nasal rinse solution inactivated HCoV greater than 99.9% with a 2-min contact time. Several over-the-counter mouthwash/gargle products including Listerine and Listerine-like products were highly effective at inactivating infectious virus with greater than 99.9% even with a 30-s contact time.”

source: https://onlinelibrary.wiley.com/doi/10.1002/jmv.26514

This is from a Rutgers study:

“The study found two other mouthwashes showed promise in potentially providing some protection in preventing viral transmission: Betadine, which contains Povidone-iodine, and Peroxal, which contains hydrogen peroxide. However, only Listerine and Chlorhexidine disrupted the virus with little impact on skin cells inside the mouth that provide a protective barrier against the virus.

Both Povidone-iodine and Peroxal caused significant skin cell death in our studies, while both Listerine and Chlorhexidine had minimal skin-cell killing at concentrations that simulated what would be found in daily use,” said Fine.”

source: https://www.rutgers.edu/news/certain-mouthwashes-might-stop-covid-19-virus-transmission


  • Wed, Jun 02, 2021 - 04:25pm



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    What is the ultimate prophylactic cocktail? Sunshine!

Dave stated, “Meeting PA guidelines” = 21 minutes of brisk walking per day.  This simple intervention is one of the most remarkably effective things you can do to protect yourself.  Better than vitamin C, zinc, melatonin, even better than vitamin D. “

If you do that walking outdoors, sun exposure produces natural Vitamin D.  so you’ve got it!

Great point Dave.

  • Wed, Jun 02, 2021 - 05:02pm


    Jim H

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    A case of chronic Hep. C cured by mushrooms?

Yes.  N=1


Antiviral Activity from Medicinal Mushrooms and Their Active Constituents
Compounds having unique antiviral properties found in mushroom mycelium and their analogs are extracted, concentrated, isolated or manufactured to create compositions useful in preventing the spread and proliferation of various viruses afflicting animals, particularly viruses harming humans, pigs, birds, bats and bees. Such compounds and compositions can be used individually or in combination with known medicines or natural products to improve health.

In this patent Paul Stamets recounted an amazing story communicated to him by one of his customers who is a doctor.  Anecdotal on it’s own… but as I have shown already in this thread there is ample evidence of compounds from mushrooms being antiviral.

On page 16 of the patent PDF you will find this amazing passage;

A physician reported that his hepatitis C viral
counts became undetectable after taking a two month regimen of Agarikon Host Defense capsules containing Fomitopsis officinalis mycelium grown on rice ( 500 mg per capsule ) . Reprinted , with permission is an exact copy of his case report . [ 0106 ] ” Here are the facts of my case . [ 0107 ] I was diagnosed with hepatitis C in 2000 or 2001 . An abnormal liver panel had alerted the MD to check for that
virus , as that’s about the time that medicine was realizing its
spread . [ 0108 ] How I got the virus I’ve never figured out , but I had
worked on an inpatient psychiatric unit in SoCal in 1987 / 88 . After that I managed large outpatient mental health clinics down there where a significant number of our patients had this virus . Another possibility is that I got it from a major surgery I had in 1992 . In any case , the MD in 2001 said that since my viral load was low , I should wait until better
treatments were available before seeking care . [ 0109 ] As you probably know , excellent treatments recently became available ( though expensive ) . My internist agreed this January to check my viral load again and although it was still relatively low , he agreed to refer me to
a gastroenterologist anyway . That fellow did a liver panel
and then at my pleading referred me on to the pharmacist for
the course of medication . That ‘ s how Kaiser Permanente®
does it — a specially – trained pharmacist manages a treatment
program . It starts with a baseline check of the viral load , then
the daily medication . As soon as the viral load drops to zero , the medications are stopped . [ 0110 ] The week before I was to attend the class , the pharmacist ordered another HCV lab test to establish the
baseline . On the day of the class , I was literally in the
facility , walking to the classroom when the pharmacist
called my cell phone . She said the lab test results had just
come in and somehow, for some reason, it showed no virus
present . She was stumped for an explanation , but said that I
couldn’t start the medication because I had no viral load to
try to reduce . [ 0111 ] I called the gastro back next day and said maybe there had been a lab error or something . It had been so hard to get the referral I didn’t want to lose this chance to get rid of the virus . He agreed to have the test redone right away , just in case . A week later he called to say that sure enough, the first test was correct . There was no viral load — I ‘ m apparently virus free . He seemed uncertain but said he’s heard stories of patients whose immune system was able to
clear the virus somehow , but he had never heard of anyone
who had carried a viral load for more than 10 years and then
have it just disappear like this . He said he had reviewed my
records and the viral load had been consistent between first
identification and the most recent test in January 2015 . But
it was gone now , seven months later . And the load was still
zero on re-test two weeks later . He said I should be happy . 10112 ] . And it is indeed a relief , as you can imagine . I thought hard for an explanation . It dawned on me that during the spring of this year , I ‘ d taken the Agarikon capsules for maybe two months . Other than that , I was taking curcumin and a vitamin , but had been taking those for years. The only change was adding the mushroom capsule . 10113 ] I ‘ d heard an interview with you on the radio . ( I don ‘ t recall what show , but it was in the middle of the night when I couldn ‘ t sleep ) . You didn’t say anything about HCV but you had mentioned the antiviral effect of certain mushrooms . I did a literature search and came across an article or patent of yours ( I forget which ) in which HCV was specifically mentioned , which is why I ordered the Agarikon from
your company . [ 0114 ) So that ‘ s my story . Obviously it ‘ s not a lab – controlled experiment , but I’ve thought hard about other possible explanations and don ‘ t have many . I hadn’t changed
any other lifestyle or dietary habit . So either this remission
is due to ( a ) meditation and prayer , ( b ) random good fortune , ( c ) the Agarikon , or ( d ) some combination of those . [ 0115 ] I used two 60 – capsule bottles of Agarikon between April and June . I always took one capsule in the morning before breakfast , and sometimes a second capsule in the evening before sleep , but that wasn’t consistent . We were down in SoCal in June and July and I wasn’t taking the
capsules there , but the lab tests that came back negative were
done in August ( done at the Kaiser facility in Fontana , Calif . ) . So any beneficial effect must have been in the spring [ 0116 ] Feel free to share my story as appropriate , but I ‘ d prefer to stay anonymous of course . ”

I just realized I am specifically out of Stamets straight Agarikon.. going to order up some more : )


  • Wed, Jun 02, 2021 - 06:57pm


    Jim H

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    Concluding the case for mushroom formulations in a prophylactic cocktail

I like the idea of adding secret weapons to my prophylactic cocktail.  For me, the primary “secret” weapons are Niacin (as straight Nicotinic acid, flush-type, 1 gram daily) and and assortment of mushroom-based pills and products.  These likely work via immune boosting effects, some of which are outlined this final paper I am linking.  The Stamets products are easy.. there are several blends aimed at immune boost and I have them all and I kind of mix up what I take day-to-day.

As we look ahead toward the threat of variants, having an even more effective prophylactic cocktail, vs for instance what is being shown now on FLCCC, is very much possible I believe.  We are never going to get a RCT comparing all these different, natural cocktail elements, so we are left to make educated decisions.  As with HIV cocktail medications, there is good reason to believe that positive effects of each component can be additive.  Like the Ivermectin molecule, mushrooms come from nature so there is good reason to believe that they are safe.


The mycelium of the Trametes versicolor (Turkey tail) mushroom and its fermented substrate each show potent and complementary immune activating properties in vitro

Both aqueous and solid fractions of FS triggered large and dose-dependent increases in immune-activating pro-inflammatory cytokines (IL-2, IL-6), anti-inflammatory cytokines Interleukin-1 receptor antagonist (IL-1ra) and Interleukin-10 (IL-10), anti-viral cytokines interferon-gamma (IFN-γ) and Macrophage Inflammatory Protein-alpha (MIP-1α), as well as Granulocyte-Colony Stimulating Factor (G-CSF) and Interleukin-8 (IL-8)…..

The results demonstrated that the immune-activating bioactivity of a mycelial-based medicinal mushroom preparation is a combination of the mycelium itself (including insoluble beta-glucans, and also water-soluble components), and the highly bioactive, metabolically fermented substrate, not present in the initial substrate.

Note:  Stamets has pioneered the use of a certain style of mushroom farming that uses brown rice as substrate and then harvests the mycelium, i.e. the roots of the mushroom vs the fruiting bodies.  The link above contains an extensive discussion of these facets after the main body of the paper.  Clearly, eating the fruiting bodies, i.e. what we think of as the mushrooms themselves, can also have medicinal value.

  • Sat, Jun 05, 2021 - 11:03am


    Jim H

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    Shall we add antihistamines?

It would seem so.  We are talking off-the-shelf Clarityn folks.  At some point you just have to snicker at the enormous number of different compounds that have been found efficacious in one way or another during the last year.  This realization further emboldens my efforts to document the options and have us consider the potential of the expanded cocktail approach to prophylaxis.


• Early treatment of COVID-19 in Primary Care with antihistamines and azithromycin.

• Antihistamines may also be considered a prophylactic treatment for COVID-19.

• Decrease in hospital admissions and fatality rate in elderly population.

• Antihistamines may control the immune response and cytokine storm in COVID-19.

  • Sat, Jun 05, 2021 - 11:24am


    Jim H

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    More nutraceutical ideas based on data

Here is the data;


In this study, we screened a botanical drug library containing 1,037 compounds and identified four hits, including angeloylgomisin O, procyanidin, schisandrin B, and oleanonic acid, which blocked the entry of SARS-CoV-2 S (ct19) pv infection by inhibiting viral membrane fusion.

And here is the action showing dose dependent behavior and associated cellular viability/toxicity.  Oleanonic acid looks maybe too toxic to mess with;

So where do we go with this information?  Why, Amazon.com, or any other favored choice for nutraceuticals;

Amazon.com: Organic Schisandra Extract Powder, 8 Ounce, Pure Schisandra Supplement, Anti Aging Adaptogenic Herb, Powerfully Supports Liver Detox, Cognitive Health and Stress Relief, No GMOs and Vegan Friendly: Health & Personal Care

  • Sat, Jun 05, 2021 - 11:44am



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    day 8


I remember that doctor from South Africa talking about antihistamines on Day 8.  I can’t recall his name, or the video where he gave his presentation, but the “day 8” part I do recall, and also the treatment: antihistamines.

I don’t think he lost a single patient.

I think this is worth pursuing at this point.  Too many things are lining up.  And some of these things are cheap and OTC – and they seem relatively benign.

Heh.  And maybe they have effects with “the shot” too.  Hmm….


While the CDC advises against ibuprofen, acetaminophen, aspirin, or antihistamines before your shot, they say “you can take these medications to relieve post-vaccination side effects if you have no other medical reasons that prevent you from taking these medications normally.” And for the latest vaccine news from Pfizer, check out The Pfizer CEO Says This Is How Often You’ll Need a COVID Vaccine.


Here you go, Dave:


The 8th Day Therapy for COVID-19

  • Sat, Jun 05, 2021 - 01:54pm



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Thanks Uber.  That’s exactly what I was looking for.

I heard the whole podcast live, but I had a hard time believing this was just treatable with antihistamines.  But now – here it is again.

The cat came back, the very next day.

“Very early on, I understood that the dyspnea that sets in seems to have a specific time in the disease. It was very quick in onset, there was differences in speed and severity, but it always seemed to present on the 8th day.”

“Some of the patients recovered by the 7th day and had none of the symptoms that occurred from the 8th day onwards.”

“From very early on, I was of the opinion we were dealing with some kind of hyper-sensitivity reaction. … Quite early on, I started steroids and patients improved … and then I attempted antihistamines.”

“I tried, on a patient who was critically ill, a dose of promethazine and … oxygen saturation returned to 95% within 24 hours. There was a remarkable improvement. This got me to understand that we were dealing with an hypersensitivity reaction.”

“I started to treat this as an hypersensitivity reaction. I found that the antihistamines, particularly antihistamine 1 & 2 blockers, for the respiratory and gastro-intestinal tracts respectively, showed great benefit, immediately.”

“With hyper-sensitivity, the most important thing is to start treatment early. The longer you leave it, the cascade of mediators will result in other sequalae and culminate into a cytokine storm.”

“But like with other hyper-sensitivity reactions, if caught early, they are easy to cut in.”

“So my entire focus became the eighth day. When patients came into my practice, I would Interrogate them about the onset of the symptoms, the exact day they started feeling unwell.”

“I would then advise them about what might transpire exactly a week later, which is the eighth day, and what symptoms to start looking for.”

“This seemed to be very typical of an allergic reaction, that you would see with rheumatoid arthritis, with joint pain. There was fatigue, to the point that patients wanted to sleep, or the onset of dyspnea.”

“I educated patients about these symptoms, and that they should not discount these symptoms, even if it was a solitary symptom and mild. Any change from the 7th to the 8th day should be reported.”

“I think that patients understood the gravity of what I was saying, and reported back on the 8th day.”

“That allowed me to run certain testing, to see if I am dealing with a complete switch on that day. The common blood tests that I ran are CRPs and Interleukin 6. I found drastic changes from the 6th day to the 9th day. It showed something was happening at the time that was showing a spike in these inflammatory markers.” …

“With that kind of treatment, I had very good clinical recovery of my patients, and in a very quick space of time.”

“I looked at this that, in the first wave, people over 55 were probably exposed to an allergen similar to coronavirus and those that were allergic had developed the relevant antibodies to have an hypersensitivity reaction. The younger population were naïve and so for a first exposure would not react at all. So they would have a mild illness and this would pass off. But it was my expectation that, in the second wave, because these patients were sensitized, we would see a far younger population presenting with hypersensitivity or mortality or morbidity.”

Worth re-reading the entire transcript.

I’ve now saved it.  🙂


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