What is the ultimate prophylactic cocktail? A thread to collect evidence

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  • Fri, Nov 05, 2021 - 02:19am

    #181
    Bill in La Mesa

    Bill in La Mesa

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    Form of Zinc / Acetate?

Chris Masterjohn has a video on using zinc acetate lozenges to kill a cold.





From what I gather, the acetate form of zinc tends to permeate tissues better than any other form; apparently from the mouth all the way to nasal tissues with the zinc acetate lozenges.

Without an ionophore, I expect the acetate form may also permeate cellular tissue better than any other form; however, a proper ionophore (HCQ/Quercetin) should adequately facilitate transport of other forms of zinc into the cell.

Bottom line…  If you’re not using an ionophore, zinc acetate is the best form to supplement with.  If you’re using an ionophore, any form of zinc should work.

  • Fri, Nov 05, 2021 - 06:53am

    #182
    Kat43

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    What is the ultimate prophylactic cocktail? A thread to collect evidence

I have a supply of the lozenges he originally recommended – LifeExtension Enhanced Zinc Lozenges.  They were the only ones he knew about at that time that had his recommended formulation of zinc.  He said once the cold symptoms started this was the zinc you had to turn to (as Bill mentioned, perhaps throwing in a zinc ionophore makes a difference).

At any rate, these are large blocky lozenges so they have to dissolve slowly in your mouth.  Annoying but effective.  They have made a huge difference in my colds.  I would turn to them for any upper respiratory virus at this point.

  • Wed, Nov 17, 2021 - 11:51am

    #183

    Jim H

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    A newly published reminder that Curcumin should be on the daily list…

H/T Covid19Crusher on Twitter.  Published yesterday.

https://www.mdpi.com/1420-3049/26/22/6900

Curcumin Inhibits In Vitro SARS-CoV-2 Infection In Vero E6 Cells through Multiple Antiviral Mechanisms

Due to the scarcity of therapeutic approaches for COVID-19, we investigated the antiviral and anti-inflammatory properties of curcumin against SARS-CoV-2 using in vitro models. The cytotoxicity of curcumin was evaluated using MTT assay in Vero E6 cells. The antiviral activity of this compound against SARS-CoV-2 was evaluated using four treatment strategies (i. pre–post infection treatment, ii. co-treatment, iii. pre-infection, and iv. post-infection). The D614G strain and Delta variant of SARS-CoV-2 were used, and the viral titer was quantified by plaque assay. The anti-inflammatory effect was evaluated in peripheral blood mononuclear cells (PBMCs) using qPCR and ELISA. By pre–post infection treatment, Curcumin (10 µg/mL) exhibited antiviral effect of 99% and 99.8% against DG614 strain and Delta variant, respectively. Curcumin also inhibited D614G strain by pre-infection and post-infection treatment. In addition, curcumin showed a virucidal effect against D614G strain and Delta variant. Finally, the pro-inflammatory cytokines (IL-1β, IL-6, and IL-8) released by PBMCs triggered by SARS-CoV-2 were decreased after treatment with curcumin. Our results suggest that curcumin affects the SARS-CoV-2 replicative cycle and exhibits virucidal effect with a variant/strain independent antiviral effect and immune-modulatory properties. This is the first study that showed a combined (antiviral/anti-inflammatory) effect of curcumin during SARS-CoV-2 infection. However, additional studies are required to define its use as a treatment for the COVID-19.

Dose vs response is awesome.. the trick is to get the dose through your gut, which is why it’s best to seek out high bioavailability versions of the supplement;

  • Sat, Nov 20, 2021 - 07:10pm

    #185
    John Anon

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    Cheap lysine supplement stops covid according to this study

I actually got myself some lysine a couple months ago because I read an article about it working in the Dominican Republic as an early treatment/prophylactic on lewrockwell.com and because some people argue that the large amount of CGG in the virus’ genome, which is the most common form of arginine in the human body is the smoking gun for human engineering. Lysine removes arginine from your system. It’s ultra cheap btw.

So now I found out that these Taiwanese researchers agree. I think this could be a big one.

“Lysine and Lys-ester can prevent SARS-CoV-2 and IAV infection, particularly in the entry stage. In contrast to that, Arg-ester can potently boost infection of both viruses. It would therefore be beneficial to consider the nutrient intake of COVID-19 and flu patients. We recommend the inclusion of lysine supplementation in addition to a reduced arginine intake for the prevention and treatment of SARS-CoV-2 and IAV infections.”

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8310019/

  • Tue, Nov 23, 2021 - 01:56am

    #186

    Jim H

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    Benadryl Allergy (Diphenyhydramine) + Lactoferrin stops SARS-CoV2 dead

Staying out of the hospital is getting easier and easier… just published.

https://www.mdpi.com/2076-0817/10/11/1514/htm

Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected Cells

….In our investigations into sigma-binding ligands, including diphenhydramine, we sought to reduce the EC50 by addition of another safe, and well characterized protein from milk, lactoferrin. The host-iron sequestration protein lactoferrin was reported to exhibit direct antiviral activity against SARS-CoV-2 [28,29], is broadly antimicrobial, and possesses host immunostimulatory properties. We tested combinations of lactoferrin with diphenhydramine to measure effects on reduction of EC50. Co-administration of 400 μg/mL of lactoferrin with diphenhydramine further reduced SARS-CoV-2 induced cytotoxicity and decreased the EC50 by 55.5% to 54.2 μg/mL (185.7 μM; Figure 8C,D). The antiviral enhancement effects of lactoferrin are more apparent at lower, therapeutically relevant concentrations of diphenhydramine (Figure 8E). Inhibition of viral replication was also investigated by qPCR (Figure 8F). Lactoferrin (400 μg/mL) was able to decrease N-protein RNA copies by 28.0% 48 h after infection, compared to DMSO alone controls while 40 μg/mL diphenhydramine alone resulted in 32.2% reduction. When combined, they inhibited 99.97% of N-protein RNA copies, a 3-log reduction that was highly significant. These data demonstrate that combinations of two over-the-counter compounds, with well characterized safety profiles, have synergistic effects on inhibition of SARS-CoV-2.

 

  • Tue, Nov 23, 2021 - 04:17am

    #187
    Canuckian

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    What is the ultimate prophylactic cocktail? A thread to collect evidence

Very interesting but I’m always a bit weary of in-vitro studies.

  • Sat, Dec 04, 2021 - 12:12am

    #188

    NZSailor

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    Timing of prophylactic theraputics?

Hello All,

This is a fantastic thread and I finally sat down and read it from beginning to end a few days ago. Thanks too Jim H for keeping it alive. Like everyone, I’ve been trying to work out the best combined protocol for this pandemic. My spreadsheet version is basically a combination of FLCCC, Chetty and some antihistamines from from a couple of strong studies that I came across. It is a living document and I’m always trying to tweak it based on new information. I’ve got a couple of questions however that I haven’t seen discussed much so I’m just going to throw them out for comment.

We really need three protocols- prophylaxis, symptomatic/viral reproduction, and inflammatory. I’m trying to pin down which therapeutics you want for each protocol, or more specifically, when to start and stop each therapeutic. I’m cognizant that I want to support my immune system and not dis-regulate it with a shotgun approach to therapeutics.  What does John Campbell say- the right drug, at the right time, at the right dosage?

As part of the prophylaxis I’m taking all the standard stuff like vitamin D/K2 and moderate amounts of things like zinc, vitamin A, and selenium. Obviously you want to go into COVID with high vitamin D levels, but as a generally healthy 60 year old what else do you think is critical to have at high levels during prophylaxis (assuming I ramp up the other things when symptomatic)?

My other prophylaxis conundrum is that it sounds like natural immunity is the best of all solutions and the ultimate end point for this pandemic. I’m worried that mandatory vaccination is coming to my country at some point (New Zealand) and I feel like I would have a far better time defending myself against it if I’ve caught COVID and recovered and could argue natural immunity as an exemption. To that end, I’d like a prophylaxis that prepares my body as best as possible to deal with COVID but I don’t really want to prevent myself from getting it. That sounds a bit like a contradiction but I don’t think it is and I’m trying to fine tune my prophylaxis for that.

My understanding is that the TH1 immune response is the one that the body uses to fight intracellular parasites such as bacteria and virus, while the TH2 response is for extracellular parasites such as helminths. However the TH1 response is the pro-inflationary one that can get out of control leading to bad cytokine outcomes in the late stage of the disease whereas a TH2 response helps shut down an overblown TH1 response and cytokine storm. So it seems to me if we’re going down the therapeutics route, we want to use therapeutics that promote the TH1 response during the viral replication phase but then stop them and use TH2 supportive/balancing therapeutics beginning about day seven of symptoms to shut down/mediate the TH1 side of things. Here’s a partial list of some therapeutics and what they stimulate (assuming these are accurate).
TH1 Stimulating Compounds:

Astragalus, Echinacea, Medicinal Mushrooms (reishi & maitake), Glycyrrhiza (found in licorice), Melissa Oficinalis (Lemon balm), Panax Ginseng, Chlorella, Grape Seed Extract, Melatonin, Andrographis

TH2 Stimulating Compounds:

Caffeine, Green Tea Extract – ECGC (be careful with thyroid), Pine Bark Extract – Pycnogenol, White Willow Bark, Lycopene, Resveratrol, Curcumin, Genistin, Quercitin

Immune Modulating Compounds: These are compounds that balance the immune system and calm it down so it doesn’t overstimulate and hyper inflame.

Fermented Foods including raw, grass-fed dairy products like amasai and cheese and sauerkraut, kimchi, natto, fermented assorted veggies. Coconut Oil, Vitamin A, Vitamin E, Colostrom, Vitamin D3, Omega 3 Fatty Acids, Glutathione Boosting Agents such as cysteine, glutamic acid and glycine.

Has anyone given some thought as to timing of the therapeutics above? Do we want to be loading up on ECGS, Curcumin, and Quercitin during the symptomatic phase of things or are these better reserved for later in the disease? And if later, when do we want to start ramping them up so that they are effective? Where is a good functional medicine consulting immunologist when you need one?

And last question- Of the people who get really sick with COVID, are they getting really sick from COVID or from their own body’s dis-regulated immune response at the back end? If severe disease is all about a cytokine/bradykine storm maybe the best therapeutics protocol doesn’t worry about the TH1/virus stuff but about TH2 response helping the body control it’s response to the virus.

  • Sat, Dec 04, 2021 - 12:50am   (Reply to #188)

    #189
    MustStayAnonymous

    MustStayAnonymous

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    What is the ultimate prophylactic cocktail? A thread to collect evidence

great post, thank you for adding to the thread.

 

Something that I keep in the back of my mind as I personally have been seeking to “thrive” as far as my health goes for the past several years is that, is it possible that you an thrive “too much” and never gain a strong immune response to an infection (because it is taken care of too quickly).  Is that even a bad thing in general?  In our case, at some point it may be important that we can show and prove natural immunity which would require the virus to stick around long enough to build sufficient antibodies to show up on a test.  One could hope that the powers that be remember natural immunity and this ever becomes a thing.

 

I bring that up, because as you mention timing of all of this, could be very important.  You don’t want to kick it too quickly, right?  You want to be able to give you system enough time to learn/program and have those antibodies.

 

The other thing about this, which I have mentioned before (at least I remember doing so) is the current overall health of the person at the time.  We could all take the same cocktail that is derived from a thread like this and could end up with wildly different outcomes, or situations that the cocktail simply “doesn’t work”.  So I know, and I hope everyone else keeps in mind, all of these solutions should be, with the best of your knowledge and the amount of sense we are bestowed with, the right amount and timing of any of this is done based on your situation.

 

For someone that is in peak health, a delayed prophylactic range could and possible should be different than someone who is not.  The trick is knowing where you stand, and I push this, because even though I took my health into my own hands roughly 10 years ago and have benefited significantly from it, I still was not doing as well as I thought I was.

 

Feel like I am ranting now, hope this provides some benefit or food for thought to those that come across it.

  • Sat, Dec 04, 2021 - 05:04am

    #190
    HPHovercraft

    HPHovercraft

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    Under investigation or was found in violation of the Medium Rules

I just tried to look up this link from Jim H’s post from earlier in this thread (page 13):

https://www.peakprosperity.com/forum-topic/what-is-the-ultimate-prophylactic-cocktail-a-thread-to-collect-evidence/page/13/#post-649856

Well written defense of Ivermectin that takes the anti-IVM propaganda head on

The link (try it yourself):

https://dianeperlman-24337.medium.com/open-letter-and-challenge-for-rachel-maddow-d75cddde06e0

The result (my emphasis):

Error
410
This post is under investigation or was found in violation of the Medium Rules

HP

 

  • Sun, Dec 05, 2021 - 04:59pm   (Reply to #188)

    #191
    John Anon

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    What is the ultimate prophylactic cocktail? A thread to collect evidence

Okay, so I’m reading some things here that I really don’t like.

First off, I am by no means a medical expert, but this idea that you should maybe let the disease progress to stage II, just to (temporarily!! because probably none of us will be able to keep refusing in the long run) get out of a vaccine mandate sounds absolutely insane to me.

Please! Do not intentionally let the virus accumulate unimpeded. The whole point of this thread is to help you AVOID getting to that stage. Because once you are in the post-viral inflammatory stage, sure there are therapeutics, but your chances of having a really bad time go up exponentially.

So listen, I’m totally on board with trying to figure out what works when and which meds should maybe be avoided in stage I or II, but let’s keep our eye on the ball. We want to stay healthy first and foremost.

Alright, now about not taking anti-inflammatories in stage I, I agree when it comes to things like cetirizin and ibuprofen, but quercetin for example is primarily there to hinder viral replication by inhibiting TMPRSS2 and 3clpro and ionizing zinc. Dropping this seems like a mistake to me.

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