What is the ultimate prophylactic cocktail? A thread to collect evidence

Login or register to post comments Last Post 0 reads   178 posts
Viewing 10 posts - 131 through 140 (of 178 total)
  • Wed, Sep 08, 2021 - 12:26pm

    #131
    Dontknownothin

    Dontknownothin

    Status Gold Member (Offline)

    Joined: Mar 14 2020

    Posts: 592

    count placeholder2

    What is the ultimate prophylactic cocktail? A thread to collect evidence

JimH,

That’s great news. Better keep it quiet though wouldn’t want TPTB to block out the sun for the sake of keeping the vax and sickcare in business.

  • Wed, Sep 08, 2021 - 01:07pm

    #132
    debu

    debu

    Status Bronze Member (Offline)

    Joined: Aug 16 2009

    Posts: 119

    count placeholder1

    Reply To: What is the ultimate prophylactic cocktail? A thread to collect evidence

Any thoughts on IVM expiry dates?  Are they hard and fast or is there a degree of latitude in adhering to them?

I seem to remember Chris once saying in a podcast that most drugs are safe and effective for years after their labelled expiry date but Karl Denninger has stated quite emphatically that taking pharmaceuticals past their expiry is placing one at risk in terms of both safety and efficacy.

What is the view of others?

 

  • Wed, Sep 08, 2021 - 01:33pm

    #133

    Jim H

    Status Bronze Member (Offline)

    Joined: Jun 08 2009

    Posts: 1617

    count placeholder2

    Regarding expiration dates

Expiration dates need to be conservative – they need to take into account worst case storage conditions.  For the most part, this means storage temperature.  The general rule of thumb is that for every 10 deg. C (~18 deg. F) increase in temp, the reaction rate doubles.  These reactions of course include those involved in the general degradation of an organic molecule like Ivermectin, and literature suggests that in this case oxidation is the enemy – noting that “AVM’s” encompass Ivermectin;

https://pubmed.ncbi.nlm.nih.gov/22863694/

….The pharmacoepial recommendations for addition of antioxidant into drug substance, as well as its products, arises from the fact that AVM are very sensitive to oxidation.

So, if you can keep your stuff cool… like cellar temperature… you almost certainly can use if safely well beyond it’s stated expiration.  Why?  Because that expiration date needs to be conservative and account for the possibility that it will sit on a shelf in an equatorial country at > 80 deg. F.  If you can keep it at 65 deg. F, it will last much, much longer.  I have placed some meds for my horse in the fridge because I am so worried that the current uproar regarding human vs horse meds is going to cause my horse to suffer.  Refrigerated meds should last indefinitely.

 

  • Wed, Sep 08, 2021 - 01:55pm

    #134
    Kat43

    Kat43

    Status Gold Member (Offline)

    Joined: Feb 10 2020

    Posts: 686

    count placeholder1

    What is the ultimate prophylactic cocktail? A thread to collect evidence

The Durvet horse paste box says to store between 68F and 77F with excursions from 59F to 86F.  That should rule out putting horse paste in the refrigerator.

When in doubt, check whether the packaging says anything.

  • Wed, Sep 08, 2021 - 02:19pm   (Reply to #134)

    #135

    Jim H

    Status Bronze Member (Offline)

    Joined: Jun 08 2009

    Posts: 1617

    count placeholder1

    horse paste questions…

Thank you Kat.. I have actually considered this.  I think that the issue is likely one of phase separation.  I don’t have all my long term horse health stash in a fridge, but I do have some there.  My intention would be that, upon removing from the cold years from now (see how I keep a positive attitude about having grid power for years to come!) I would dispense the entire contents into a small bowl or vessel and mix/blend/re-disperse for accurate dosing.  I don’t see how any harm can come of colder temps other than phase separation, which of course could make dosing less accurate.   Am I missing something?

  • Wed, Sep 08, 2021 - 02:35pm   (Reply to #134)

    #136
    RandomMike

    RandomMike

    Status Silver Member (Offline)

    Joined: Mar 12 2020

    Posts: 346

    count placeholder1

    What is the ultimate prophylactic cocktail? A thread to collect evidence

I have frozen and unfrozen it, no separation, all ok.

Recently acquired two bottles of Qunol brand turmeric.  Wondering which is best for our purposes here?

“Qunol Extra Strength Turmeric Cucumin Complex, Ultra High Absortion.”  Ingredients: Bioenhanced Turmeric Complex (Cucuma Longa) Rizome (18-22% Curcuminoids).  Purchased online, ~$30.

“Qunol Turmeric, 95% Curcuminoids, Enhanced Absorption.”  Ingredients: Turmeric Root Extract (95% Curcuminoids), Black Pepper Root Extract.  From Costco, ~$30 on sale.

Appreciate input.  Aloha, Steve.

  • Wed, Sep 08, 2021 - 03:05pm

    #138
    Kat43

    Kat43

    Status Gold Member (Offline)

    Joined: Feb 10 2020

    Posts: 686

    count placeholder0

    Reply To: What is the ultimate prophylactic cocktail? A thread to collect evidence

Thatchmo, I don’t have an opinion about which curcumin would be better, but I’m including a link to an article about the synergistic benefit of taking curcumin along with bromelain.  The article says that bromelain will substantially increase the absorption of curcumin and they both have a role in Covid.

https://pubmed.ncbi.nlm.nih.gov/33205039/

  • Wed, Sep 08, 2021 - 03:13pm   (Reply to #134)

    #139
    Phred

    Phred

    Status Bronze Member (Offline)

    Joined: Dec 16 2020

    Posts: 109

    count placeholder0

    Paste storage temperature

I suspect the manufacturer is avoiding possible lawsuits related to horse injury from administration either too-hot or too-cold.   A quick search shows horses prefer lukewarm 45 to 68 F water.

I have 10 tubes woth various expiration date in the fridge vegetable drawer.  The brand I have has no oxygen seal which leads me to think they would rather have it oxidize faster  than worry about product tampering.  They are in a ziplock bag for now. Next time I open it I will try pulling a vacuum on one in a mason jar.

  • Wed, Sep 08, 2021 - 03:16pm   (Reply to #128)

    #140
    Acorn Endeavors

    Acorn Endeavors

    Status Bronze Member (Offline)

    Joined: Mar 02 2020

    Posts: 109

    count placeholder1

    What is the ultimate prophylactic cocktail? A thread to collect evidence

I use this one, though it’s not cheap!

Viewing 10 posts - 131 through 140 (of 178 total)

Login or Register to post comments