What is the ultimate prophylactic cocktail? A thread to collect evidence

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  • Wed, Aug 25, 2021 - 10:14pm

    #121

    Jim H

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    Posts: 1657

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    We now know why interceding at the point of mucosol entry is so important

H/T Walter Chesnut, aka parsifaler.  From one month ago… It takes down your natural defenses.  That’s why supporting your mucosol defenses is SO important.

https://www.nature.com/articles/s41467-021-24521-x

Abstract
Understanding how SARS-CoV-2 spreads within the respiratory tract is important to define the parameters controlling the severity of COVID-19. Here we examine the functional and structural consequences of SARS-CoV-2 infection in a reconstructed human bronchial epithelium model. SARS-CoV-2 replication causes a transient decrease in epithelial barrier function and disruption of tight junctions, though viral particle crossing remains limited. Rather, SARS-CoV-2 replication leads to a rapid loss of the ciliary layer, characterized at the ultrastructural level by axoneme loss and misorientation of remaining basal bodies. Downregulation of the master regulator of ciliogenesis Foxj1 occurs prior to extensive cilia loss, implicating this transcription factor in the dedifferentiation of ciliated cells. Motile cilia function is compromised by SARS-CoV-2 infection, as measured in a mucociliary clearance assay. Epithelial defense mechanisms, including basal cell mobilization and interferon-lambda induction, ramp up only after the initiation of cilia damage. Analysis of SARS-CoV-2 infection in Syrian hamsters further demonstrates the loss of motile cilia in vivo. This study identifies cilia damage as a pathogenic mechanism that could facilitate SARS-CoV-2 spread to the deeper lung parenchyma.

  • Mon, Aug 30, 2021 - 11:06am

    #122

    Jim H

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    Well written defense of Ivermectin that takes the anti-IVM propaganda head on

https://dianeperlman-24337.medium.com/open-letter-and-challenge-for-rachel-maddow-d75cddde06e0

  • Mon, Aug 30, 2021 - 11:29am   (Reply to #122)

    #123
    Dontknownothin

    Dontknownothin

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    What is the ultimate prophylactic cocktail? A thread to collect evidence

JimH,

I would disagree with her contention that Rachel Maddow is a free thinking, intelligent investigator. But the article cites many valuable facts and certainly bridges the narrative gap between left and right with fact. I doubt the appeal will make any headway before the tipping point is reached and its too late for MSNBC viewers.

  • Mon, Aug 30, 2021 - 12:16pm

    #124

    Jim H

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    Posts: 1657

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    New Quercetin + Zinc data.. and a hearty LOL to Don’tknownothin

Of course I agree… the good news is that the writer seems to be another “classic” left of center liberal who sees that truth is being suppressed and who values truth seeking over political affiliation.  She is trying to engage Rachel and thus is not willing to tag her as being disingenuous.  I think we all know better.

I put Bret Weinstein and Heather Heying (of the Darkhorse podcast) in the same category… they are not “conservatives” by any stretch.  We need these voices from left of center to effectively counter the divide-and-conquer politicization of medical and scientific truth.

Now onto the good news on a protocol that includes Quercetin + Zinc;

https://journals.sagepub.com/doi/full/10.1177/2515690X211026193

Here is the protocol;

Oral administration was the sole method of administration assessed
in this study.  For disease prophylaxis. One dose daily of the full core formulation regimen, containing:
25 mg zinc;
10 drops of Quina™ (on average; the quina-bark extract may be
titrated, as tolerated by some subjects, starting at 1 drop then
building up to 8-16 drops daily, but which latter may be taken as
two 4-8 drop half-doses twice daily);
400 mg quercetin;
1000 mg vitamin C;
1000 IU (25 mg) vitamin D3;
400 IU Vitamin E; and
500 mg l-lysine.

The results were pretty spectacular in terms of prophylactic benefit;

Results.
While both groups were moderate in size, the difference between them in outcomes over the 20-week study period was large and stark: Just under 4% of the compliant test group presented flu-like symptoms, but none of the test group was COVID-positive; whereas 20% of the non-compliant control group presented flu-like symptoms, three-quarters of whom (15% overall of the control group) were COVID-positive.

Bang!  No IVM involved.  Realize this was a fairly extensive cocktail that included both quercetin AND a quina bark extract, so we can’t suss apart the component benefits.  But still the study stands as being suggestive that we can potentially practice a very strong cocktail prophylaxis while holding IVM for use at first onset of any symptoms, as is my current practice.  The entire paper is worth a read as it takes time to discuss mechanisms of action behind each component.

The message becomes more clear every week;  Covid-19 is readily treatable by a long list of medicinal agents and supplements.  Many different combinations are likely effective both as prophylaxis and as early treatment.

 

 

 

  • Mon, Aug 30, 2021 - 04:54pm

    #125
    Kat43

    Kat43

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    Chris Masterjohn Vitamin D/Covid lecture

Chris Masterjohn’s recent review of Vitamin D/Covid articles:

https://chrismasterjohnphd.com/blog/2021/08/28/vitamin-d-and-covid-19

He’s my go-to nutritionist.  Some take aways for me from the lecture.

Early on there was reason to believe Vitamin D might be contraindicated in treating Covid because of its relationship to the ACE2 receptor, but studies are showing benefit.

High serum levels help prevent Covid infection.

Vitamin D is rapidly depleted during infection, so regardless of your level going in you might want to take some very large doses until recovered.  If you were low going in, then even more during the first week.  (He suggests much higher levels than, for instance, FLCCC.)  Studies that showed low levels at the point of hospitalization may be the result of this – that the disease had already knocked Vit D down.  In other words, at the time of hospitalization, low Vit D may be correlated but not necessarily causative, of severe disease.

Very important to take balancing amounts of Vitamins A and K2 if you are supplementing high levels of Vitamin D.  (What I had previously learned from Masterjohn is that an excess of A or D can create a deficiency of the other.  They’re tied together.)   Besides, Vitamin A is also important in fighting the infection.

  • Sat, Sep 04, 2021 - 01:40pm

    #126

    Jim H

    Status Silver Member (Offline)

    Joined: Jun 08 2009

    Posts: 1657

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    Reviewing Melatonin, evidence and mechanism

While delving into mechanistic speculation, this paper refers to the original realization that Melatonin works… and this was a beautiful paper in my estimation because the melatonin was not originally given to treat Covid-19.. rather it was given in attempts to help ventilated hospitalized patients sleep.  In a review that correlated the various treatments to outcomes, the data literally screamed that melatonin was having a huge positive effect, even though it was not given for that purpose;

https://openheart.bmj.com/content/openhrt/8/1/e001568.full.pdf

Paper Title:  Melatonin may decrease risk for and aid
treatment of COVID-19 and other RNA
viral infections

A retrospective analysis of 791 intubated
patients with COVID-19 has found that, after
adjustment for pertinent demographics and
comorbidities, those treated with melatonin
had a markedly lower risk for mortality (HR:
0.131, 95% CI: 0.076 to 0.223)—suggestive of
a profound anti-inflammatory benefit. ref 1

There it is.  Clear and simple.  HR, or hazard ratio of .13 means, simply stated, that your odds of dying were 87% less than those whose treatment did not happen to include melatonin.

We have often discussed here how inept it is of our government health officials to not push more vitamin D3 supplementation.  We could say the same regarding melatonin.  It’s an absolute no-brainer to use melatonin, if not for prophylaxis, for early treatment.  Of course it is listed in both FLCCC protocols (prevention, and early treatment) at the 6mg and 10 mg once daily at bedtime levels.  I wanted to re-emphasize the why.

For those of us vocally fighting against the medical and scientific nihilism.. it’s important to be armed with the technical depth to fight against the “no early treatment works” narrative.  This (reference 1 in the attached paper – I will link it separately below) is one of those seminal papers to make use of.

  https://www.medrxiv.org/content/10.1101/2020.10.15.20213546v1

 

  • Sat, Sep 04, 2021 - 01:46pm   (Reply to #126)

    #127
    Ision

    Ision

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    What is the ultimate prophylactic cocktail? A thread to collect evidence

Such is the benefit of SLEEP…

  • Sun, Sep 05, 2021 - 04:38pm

    #128

    Jim H

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    Joined: Jun 08 2009

    Posts: 1657

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    Beyond the FLCCC list; The case for NAC

Many of us count NAC as a component of our daily prophylactic cocktail.  I take 500 mg daily, sometimes with my morning Niacin flush, sometimes not.

My philosophy is to add as many layers to the prophylaxis as possible.  Beyond the FLCCC list of immune-supportive supplements, which consists of Vitamins D3, C, Zinc, quercetin, and melatonin, I add;  high bioavailability curcumin, daily Niacin flush, various Host Defense brand mushroom antivirals, Selenium, and finally, NAC.  I have written about the evidence for most of these in this thread, but I don’t recall if we covered NAC.  Recalling that the FDA has put some limited efforts in to regulate NAC, we have at least this one good reason to believe it probably is good for us : )

But, there’s science too;

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649937/

Published online 2020 Nov 2. doi: 10.2147/TCRM.S273700

N-Acetylcysteine to Combat COVID-19: An Evidence Review

In 1997, De Flora et al demonstrated that oral administration of NAC (600mg, bid) significantly improved cell-mediated immunity, shifting from anergy to normoergy in seniors (Figure 1A).21 Anergy represents a lack of reaction from immune cells to foreign substances, such as bacteria and viruses. Unsurprisingly, NAC treatment significantly decreased the frequency of influenza, as well as the severity and duration of most symptoms (Figure 1B). Although the infection rates of influenza virus (H1N1 Singapore 6/86) were similar in the two groups, only 25% of virus-infected subjects in NAC group developed flu symptoms, contrasting with 79% of the subjects in the placebo group. As a result, NAC may improve compromised cellular immunity and prevent development of certain respiratory virus-caused diseases, thus raising the question: Can NAC administration benefit COVID-19 patients?

Dramatic reduction in tendency toward symptomatic flu…  I’ll take it!

  • Sun, Sep 05, 2021 - 04:48pm

    #129

    Jim H

    Status Silver Member (Offline)

    Joined: Jun 08 2009

    Posts: 1657

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    If you are new here, consider reading through this thread….

While we wait to see if the new incarnation of peakprosperity.com will incorporate some kind of wiki function as a means to build readily accessible tribal knowledge in areas of interest… this thread is my best attempt to create something like it.  This is a curated thread.. meaning I have kept it alive and on point through making > 50% of the posts myself.  You can read it and get a large dose of the evidence behind various components of a supplementation protocol meant to protect you from Covid-19.  This is not meant to promote a lack of focus on “active” health improvement, like getting good sleep and losing weight.

I bring it back to the front page every once in a while.. otherwise you can always find this thread by doing a DuckDuckGo search using the following string;  ultimate prophylactic cocktail peak prosperity

  • Wed, Sep 08, 2021 - 12:19pm

    #130

    Jim H

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    Posts: 1657

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    More data on Vitamin-D. It’s literally a wonder “drug”

Along with the suppression of the truth about, and access to, Ivermectin and HCQ, the crimes of our totally pharma-captured gov’t “health” bodies and medical organizations include the suppression of truth about Vitamin-D.  Yes, it’s in much of our milk, but the sick care industry has made sure it’s not enough.. or at least they have not fixed the obvious problem.  What problem(s)?

https://vitamindforall.org/letter.html

Vitamin D is well known to be essential, but most people do not get enough. Two common definitions of inadequacy are deficiency < 20ng/ml (50nmol/L), the target of most governmental organizations, and insufficiency < 30ng/ml (75nmol/L), the target of several medical societies & experts.2 Too many people have levels below these targets. Rates of vitamin D deficiency <20ng/ml exceed 33% of the population in most of the world, and most estimates of insufficiency <30ng/ml are well over 50% (but much higher in many countries).3 Rates are even higher in winter, and several groups have notably worse deficiency: the overweight, those with dark skin (especially far from the equator), and care home residents. These same groups face increased COVID-19 risk.

It has been shown that 3875 IU (97mcg) daily is required for 97.5% of people to reach 20ng/ml, and 6200 IU (155mcg) for 30ng/ml,4 intakes far above all national guidelines. Unfortunately, the report that set the US RDA included an admitted statistical error in which required intake was calculated to be ~10x too low.4 Numerous calls in the academic literature to raise official recommended intakes had not yet resulted in increases by the time SARS-CoV-2 arrived. Now, many papers indicate that vitamin D affects COVID-19 more strongly than most other health conditions, with increased risk at levels < 30ng/ml (75nmol/L) and severely greater risk < 20ng/ml (50nmol/L).1

If you get sick with Covid-19 and you have not been dosing regularly with Vitamin D.. you can take bolus doses of 60,000 IU daily for more than a week with great effect and safety;

https://www.nature.com/articles/s41598-021-90189-4

If you act proactively and get your Vitamin D3 blood levels up to or above 30 ng/ml, you will not just have better prepared immuno-terrain in the face of Covid-19, you will have a distinct advantage in terms of heart attack (MI) risk and all cause mortality;

https://academic.oup.com/jes/article/5/10/bvab124/6321994

In patients with Vit-D deficiency and no prior history of MI, treatment to the (25-OH)D level of >20 ng/mL and >30 ng/mL was associated with a significantly lower risk of all-cause mortality. The lower risk of MI was observed only in individuals maintaining (25-OH)D levels ≥30 ng/mL.

 

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