What is the ultimate prophylactic cocktail? A thread to collect evidence

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  • Sun, May 23, 2021 - 10:03pm

    #1

    Jim H

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    What is the ultimate prophylactic cocktail? A thread to collect evidence

The number of supplements and substances now showing some efficacy against catching and/0r suffering from Covid-19 seems to grow by the week.  We don’t know for sure, but we can imagine that many of these work by different mechanisms, and that many of them can work in an additive, or synergistic way in terms of increasing levels of efficacy against infection and Covid-19 disease.

Because useful information can easily get atomized across threads and pretty much lost forever given the structure of this website, I have twice before initiated what I would term “curated” long lived subject-specific threads that I put continuing energy into, the latest dedicated to commentary around the hypothesis of Dr. Geert Vanden Bossche.

In discussing components of a prophylactic cocktail, I think it would be beneficial to have some degree of categorization, especially since for some obvious components like Vitamin D there exists lots of readily available information, but for others like Flush Niacin, and mushroom-based antivirals, there does not.  Here are some of the categories I imagine would be helpful for organizing thoughts or comments – if someone imagines a more useful taxonomy please speak up.

–  Vitamins and Minerals

–  Mushrooms, and mushroom-based nutraceuticals

–  Flush Niacin

–  Compounds or formulations useful as nasal spray/nasal irrigation/mouthwash

–  Melatonin

–  Other nutraceuticals or plant-derived compounds

–  Ionophores like Quercetin and Green tea extracts

–  Others

Kids hardly ever get very sick with Covid-19 thanks to their high functioning innate immune systems.  We have all read many papers showing that various single substances and small cocktails have significant efficacy in protecting, for instance, middle-aged health care workers from developing measurable or symptomatic Covid-19.  There is no reason we can’t build a better cocktail by accumulating this learning and putting it into action.

 

 

  • Sun, May 23, 2021 - 11:43pm

    #2

    Jim H

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    Fighting on the initial front-lines: Mucosal entry point

This seems like a good place to start since we have had at least two new papers outlining the efficacy of povidone/Iodine, aka Betadine, and Silver nanoparticles as inhalants, mouthwash gargle, or nasal irrigants.  The third compound of interest that I have seen mentioned is Iota-carageenan, a sea weed extract.

From page 17 of a paper by Stephanie Seneff and Greg Nigh we find this paragraph, which speaks to the importance of winning the battle at the mucosal front;

Worse Than the Disease? Reviewing Some Possible Unintended Consequences of the mRNA Vaccines Against COVID-19 (ijvtpr.com)

https://ijvtpr.com/index.php/IJVTPR/article/view/23/36

….Many who test positive for COVID-19 express no symptoms. The number of asymptomatic, PCR-positive cases varies widely between studies, from a low of 1.6% to a high of 56.5% (Gao et. al., 2020). Those who are insensitive to COVID-19 probably have a very strong innate immune system. The healthy mucosal barrier’s neutrophils and macrophages rapidly clear the viruses, often without the need for any antibodies to be produced by the adaptive system. However, the vaccine intentionally completely bypasses the mucosal immune system, both through its injection past the natural mucosal barriers and its artificial configuration as an RNA-containing nanoparticle. As noted in Carsetti (2020), those with a strong innate immune response almost universally experience either asymptomatic infection or only mild COVID-19 disease presentation. Nevertheless, they might face chronic autoimmune disease, as described previously, as a consequence of excessive antibody production in response to the vaccine, which was not necessary in the first place.

Here is the paper discussing efficacy of Silver nanoparticles as gargle and/or nasal spray… WOW!

 https://www.medrxiv.org/content/10.1101/2021.05.20.21256197v1.full.pdf+html

The incidence of SARS-CoV-2 infection (p = 0.000), was significantly lower in the experimental group vs the control group, where 1 .8% (2 participants out of 114) and 28.2% (33 participants out of 117) were infected respectively.

It looks like a similarly strong effect can be had with povidone/iodine, especially if you take the nasal irrigation route.  This study was performed on PCR-positive cases >/= 18 years old, with symptoms.  The best results were in the cell with a 0.5% solution of betadine as nasal irrigation (this means basically squirting it in one nostril and letting it come back out the other over a sink, using something like this  http://www.healze.com/benefits-of-nasal-irrigation/ .

There was only one application and then the subjects were retested – it’s not clear to me from a quick read how much time was allowed to elapse.  In any event, the outcome was pretty striking;  Upon retest the 0.5% nasal irrigation cell showed 92.6% negative (N=25) and 7.9% (N=2) still positive for Covid-19.  In the control cell using deionized water, 70.4% (N=19) were still positive, while 29.6% (N=8) were now negative.  Obviously, the treatment had a dramatic effect on accelerating viral clearance.

https://link.springer.com/article/10.1007/s12070-021-02616-7#Tab1

Another compound of interest that could be applied through spray or irrigation is carageenan.  It has been shown to act against the virus in-vitro;

  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0237480

Iota-carrageenan neutralizes SARS-CoV-2 and inhibits viral replication in vitro

And here it’s use led to an 81% reduction in infections vs control;

https://www.medrxiv.org/content/10.1101/2021.04.13.21255409v1

Findings A total of 394 individuals were randomly assigned to receive I-C or placebo. Both treatment groups had similar baseline characteristics.

The incidence of COVID19 was significantly lower in the I-C group compared to placebo (1·0% vs 5·0%) (Odds Ratio 0·19 (95% confidence interval 0·05 to 0·77; p= 0·03).

So for me the message is clear;  Everyone serious about prophylaxis should be practicing one or more of these front line defenses.  Just today I bought some betadine 10% solution and figured out how to dilute it down to 0.5% (one teaspoon, or 5 ml, up to the 100ml mark on my nose squirty thing bottle with water).  I have colloidal Silver in the house and I will try that too.  Iota-carrageenan is water soluble and readily available from Amazon.

  • Sun, May 23, 2021 - 11:59pm

    #3
    davefairtex

    davefairtex

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    interventions vs substances

I’d like to request we generalize things to “interventions” rather than just substances.

First – an Activity Intervention:

https://bjsm.bmj.com/content/bjsports/early/2021/04/07/bjsports-2021-104080.full.pdf

Patients with COVID-19 who were consistently inactive had a greater risk of

  • hospitalisation (OR 2.26; 95% CI 1.81 to 2.83),
  • admission to the ICU (OR 1.73; 95% CI 1.18 to 2.55) and
  • death (OR 2.49; 95% CI 1.33 to 4.67)

due to COVID-19 than patients who were consistently meeting physical activity guidelines.

“Meeting PA guidelines” = 21 minutes of brisk walking per day.  This simple intervention is one of the most remarkably effective things you can do to protect yourself.  Better than vitamin C, zinc, melatonin, even better than vitamin D.  Raw numbers: Inactive: 2.4% died vs active: 0.4% died (OR=6; 2.4/0.4), but after adjusting for all the usual things, OR for mortality=2.49, which is still ridiculously important.  For many of us – no excuses – schedule a walk every day.  21 minutes.   Assuming you don’t want to die, that is.

Second – BMI:

https://www.thelancet.com/journals/landia/article/PIIS2213-8587(21)00089-9/fulltext

This article provides a J-curve for BMI.  Basically, your chances of a bad COVID outcome for your age bracket increases by 8% for each BMI point above 25, on average.  This number jumps to 13% per point below age 60: [BMI=35 age 55 => 3.39 TIMES higher rate of death vs BMI=25].  A normal BMI is just as important as PA.  I’ve found IF to be effective – I don’t eat breakfast.

 

And a substance – melatonin:

https://consultqd.clevelandclinic.org/melatonin-a-promising-candidate-for-prevention-and-treatment-of-covid-19/

Analysis of patient data from Cleveland Clinic’s COVID-19 registry also revealed that melatonin usage was associated with a nearly 30% reduced likelihood of testing positive for SARS-CoV-2 after adjusting for age, race, smoking history and various disease comorbidities. Notably, the reduced likelihood of testing positive for the virus increased from 30 to 52 percent for African Americans when adjusted for the same variables.

 

Wouldn’t it be nice to have a permanent section of the site that archives this stuff?  “COVID interventions & evidence of efficacy.”  Or something like that.

  • Mon, May 24, 2021 - 12:52am

    #4

    sand_puppy

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    1 tsp Betadine in 100 ml water via nasal irrigation

Sounds like a mixing formula to remember for Betadine.

I have a Neti Pot that I use during allergy season.  Maybe I should add nasal irrigation with dilute Betadine to my routine on days when I’m exposed to lots of viruses.

Cumulative recommendations:

  • Betadine nasal irrigation
  • Maintain good weight
  • Walk/bicycle daily
  • Melatonin
  • Mon, May 24, 2021 - 01:03am

    #5

    Jim H

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    Yes Dave, let’s be open to all interventions, actions, substances..

If we want to be holistic about it, we should consider everything, not just the substances that could be accumulated into a cocktail.  Indeed, I remain very aware of Dr. Seheult’s early (in the Covid crisis) call for longer sleep.





  • Mon, May 24, 2021 - 07:29am   (Reply to #2)

    #6
    Canuck21

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    What is the ultimate prophylactic cocktail? A thread to collect evidence

Betadine is a brand name. It is not limited to its povidone iodine products. The company also sells a nasal spray based on iota-carrageenan. It’s only 20 ml though so not cheap as it costs about 10 USD in Canada at least. I use it before going grocery shopping for example.

When discussing nasal and sinus protection don’t forget nebulizing hydrogen peroxide diluted in saline solution. I do that after I have contact with vax’d people. It is cheap as chips and though it seems a hassle it’s dead easy after the first time you do it.

  • Mon, May 24, 2021 - 08:23am   (Reply to #4)

    #7
    Canuck21

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    Melatonin daily?

Is it okay to take melatonin daily? My pharmacist here told me no. She said it should only be used temporarily until one’s body restores its natural production after one’s stress level returns to “normal”, whatever that is these days…

  • Mon, May 24, 2021 - 08:40am

    #8
    Canuck21

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    Reply To: What is the ultimate prophylactic cocktail? A thread to collect evidence

Adding another one here: optimize your gut microbiome

says Dr Sabine Hazan of California speaking here around the 2 hour mark:

https://www.youtube.com/watch?v=nGefHqcnmio&t=1s

  • Mon, May 24, 2021 - 09:11am

    #9

    JAG

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    What is the ultimate prophylactic cocktail? A thread to collect evidence

2 parts baloney + 3 parts snake oil + a squeeze of silver = COVID cocktail

Just joking. This thread is actually a great idea. I second the thought of making it a permanent fixture on the site.

There is so much spam on the site that as soon as a thread falls off the main page I can no longer find it.

Maybe we need to form chain gangs to clean up the trash (spam) from this information highway.

  • Mon, May 24, 2021 - 09:17am

    #10
    LBL

    LBL

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    What is the ultimate prophylactic cocktail? A thread to collect evidence

I wear a ski parka when I walk up hill, to make me sweat more when I exercise.

 

I would love to hear more from Chris, about how we can alter our blood chemistry to make it better prepared for an encounter with Covid19.

 

I would bet money that exercise, and exercise with “extra sweat”, both help to stack the odds against a Covid outbreak.  i.e., they help the immune system.

 

But how ?  That’s the molecular biology part of the question.

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