Vitamin-D: Drops, not Tablets

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  • Thu, Sep 17, 2020 - 09:32am

    #1

    davefairtex

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    Vitamin-D: Drops, not Tablets

I was doing a deeper dive (don’t ask me why) on the massive study out of Israel on Vitamin D, and I ran across this little gem.

https://www.medrxiv.org/content/10.1101/2020.09.04.20188268v1.full.pdf

Model (3) incorporates the purchase of vitamin D formulations 120 days to 15 days before the index date. When studying separately individual vitamin D formulations available in CHS pharmacies , we were surprised to observe diverging results, with acquisition of some vitamin D formulations associated with significantly decreased risk for SARS – CoV-2 , while others were associated to significantly increased risk. Interestingly, the common feature of the vitamin D formulations which were associated with decreased risk were that they were provided as drops, so we grouped acquisition of vitamin D drops these under one variable, tablet-form being the second most common other form, we grouped their acquisition as another variable. After controlling for ethnic group and baseline vitamin D levels, acquisition of vitamin D drops was associated with a significant decrease in risk OR=0.905 (95% CI 0.848-0.967), and acquisition of vitamin D tablets was associated with a significant increase in risk OR=1.248 (95% CI 1.152 -1.3 52 )

So…Vitamin-D drops, not tablets.

They’re guessing, of course, but I thought it was worth mentioning.

  • Thu, Sep 17, 2020 - 10:20am

    #2
    TWalker5

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    Vitamin-D: Drops, not Tablets

Likely due to the fact that vitamin D is fat-soluble. No fat, no absorption. I take mine as a gel cap where the D3 is suspended in fish oil.

T.

  • Thu, Sep 17, 2020 - 10:27am

    #3
    RandomMike

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    Vitamin-D: Drops, not Tablets

If solid tablets I could see that, but what is diff between the liquid in a gel cap and a drop?

  • Thu, Sep 17, 2020 - 10:45am

    #4
    TWalker5

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    Vitamin-D: Drops, not Tablets

I doubt there’s any difference between a gel cap and a drop as far as absorption is concerned.

  • Thu, Sep 17, 2020 - 11:06am

    #5

    davefairtex

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    gel caps vs drops – a proposed difference

Here’s what the people who did the observational study said:

We propose a putative explanation for these observations: the virus port of entry is the oropharynx, it is where it first reaches mucosal membranes, initially replicates and causes its first detectable effects (anosmia, agusia, sore throat) . High vitamin D concentration in the oropharynx might be the most important factor that prevents this initial infection and replication. Vitamin D in drop forms is likely mostly absorbed by the mucous membranes of the oropharynx, and the vitamin D concentration there is likely to be elevated following drops intake. Conversely, vitamin D tablets are absorbed further in the gastrointestinal track, and vitamin D concentration reaching back the oropharynx might not provide adequate protection.

I encourage you to read the study.  It might be important.

Also in the study: they found if you live in a community with high vitamin-D deficiency, you are more likely to be infected.  They postulate that vitamin-D sufficiency provides a form of “herd immunity” which benefits everyone in the community.

Notice the multiplying effect on the black & latino communities – they are much more vitamin-D deficient, and thus suffer both an increased individual susceptibility, as well as increased exposure from their community.

A double whammy.

  • Thu, Sep 17, 2020 - 12:55pm

    #6
    RandomMike

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    Pop Vit D caps in your mouth?!

Moms cod liver oil was a good idea.

Also, might be good to pop those Vit D gel/liquid caps with your teeth and swish it around as you swallow.

  • Thu, Sep 17, 2020 - 03:31pm

    #8
    Grover

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    Not Just Coincidental

Dave,

Good find on the study! At your suggestion, I read it. It is interesting that cultural practices that limit exposed skin have such poor results concerning SC2 infection. I wonder how full time residents at nudist colonies fare?

When discussing their findings, this sentence caught my eye.

Most of the African continent, where sun is abundant and people wear light garments, appears to have been spared by this pandemic.

Isn’t most of the African continent still plagued by malaria? Wouldn’t HCQ, an anti-malaria drug, provide some protection against infection? Did they ignore that on purpose?

Nonetheless, virus caused colds and flus generally spike during the dark, dreary days of winter. People stay indoors more and keep bundled up when going outside to keep the body warm. Less sunlight on less skin for shorter durations means less vitamin D is being manufactured. That can’t just be coincidental.

Perhaps by attempting to keep Covid in check, we’ll lessen the overall cold and flu cases this year. Anyone want to bet big Pharma takes credit for a reduction in cases due to their flu vaccine?

Grover

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