Vaccines

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  • Tue, Nov 19, 2019 - 11:02am

    #91

    sand_puppy

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    Perinatal Immune Activation Gives "Autism" in Male Mice

The thesis that some autism, especially in males, is triggered by Immune Activation (IA) near the time of birth, continues to gain support.

Maternal and early postnatal immune activation produce sex-specifc effects on autism-like behaviors and neuro-immune function in mice

In this study just published in Nature by a Harvard University research team, pregnant mice were injected with Poly IC (which stimulates the mother’s immune system similar to a viral infection) or mice pups were injected shortly after birth with LPS (which stimulate the immune system like a bacterial infection would).

Male mice seem to develop the mouse equivalent of “autism like behaviors”  (anxiety in novel situations, reduced social interactions, repetitive behaviors) after perinatal immune activation.  The brain changes last long after the injection.

Post mortem brain analysis in these mice showed inflammatory proteins, and mRNA.

—————–

This continues a similar string of articles.

1  Also from Harvard, 2017, The role of oxidative stress, inflammation and acetaminophen exposure from birth to early childhood in the induction of autism.

2.  A Chinese University, 2018, IL-4 Mediates the Delayed Neurobehavioural Impairments Induced by Neonatal Hepatits B Vaccination… Cytokine. volume 10, 2018, p 137-149, Xiao Wang

We have previously verified that neonatal hepatitis B vaccination induced hippocampal neuroinflammation and behavior impairments in mice.

3.  J Neurosci. 2007 Oct 3;27(40):10695-702.  Maternal immune activation alters fetal brain development through interleukin-6.

4.  Neonatal cytokine profiles associated with autism spectrum disorder.  Biol Psychiatry. 2017 Mar 1; 81(5): 442–451.

  • Wed, Nov 27, 2019 - 10:18am

    #92

    000

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    More polio cases now caused by vaccine than by wild virus

https://apnews.com/7d8b0e32efd0480fbd12acf27729f6a5

Added to this thread, for the record.

  • Fri, Nov 29, 2019 - 12:50pm   (Reply to #92)

    #93
    Doug

    Doug

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    re: More polio cases now caused by vaccine than by wild virus

Being a survivor of polio when I was 3yo, I’m kind of sensitive to this topic.  The questions that immediately come to mind:

1.  So, 9 cases of this specific (type 2 virus) vaccine related polio in four African countries, which have over 230,000,000 population (https://en.wikipedia.org/wiki/List_of_African_countries_by_population).  Since the virus has been eliminated in the ‘wild’, there is no control group to assess how effective the live virus is against  background infections.

2.  Apparently the injectable vaccine does not result in any polio cases.  So, spending some more money would eliminate even those 9 cases.  What is the cost benefit analysis?

Should we blame the vaccines or the failure to properly and fully administer them?

  • This reply was modified 1 month, 3 weeks ago by  Doug.
  • Sun, Dec 22, 2019 - 01:16pm

    #95

    gallantfarms

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    HPV Vaccine Causing Infertility?

Yet another form of censorship:  Published peer-reviewed studies that question vaccine safety are routinely retracted from journals for vague reasons.  Meanwhile, whistleblower William Thompson has thousands of documents to verify that the CDC committed scientific fraud on their vaccines/autism study yet that study has never been retracted!

By Gayle DeLong, CHD Contributing Writer

About the sudden withdrawal of my paper, “A lowered probability of pregnancy in females in the USA aged 25-29 who received a human papillomavirus vaccine injection” in the Journal of Toxicology and Environmental Health.
In June 2018, the Journal of Toxicology and Environmental Health, Part A published my article “A lowered probability of pregnancy in females in the USA aged 25-29 who received a human papillomavirus vaccine injection”.  Data revealed that 60% of women who had not received the HPV vaccine had been pregnant at least once, while only 35% of HPV vaccine recipients had ever conceived.  The article detailed the statistical analysis as well as offered possible biological mechanisms for the results.  Three researchers peer-reviewed the article.  When the article first appeared, the editors eagerly promoted it by making it free.  By early December 2019, the number of downloads reached close to 24,000.

On October 23, 2019, I received an email stating that academic publisher Taylor & Francis and Editor-in-Chief Dr. Sam Kacew had opened an investigation of the paper, based on “several public and private expressions of concern about flaws in analysis.”  They gave me two weeks to respond to comments from four post-publication reviewers, and I did so.  On December 10, 2019, I received an email from Taylor and Francis stating that despite my comments, the “concerns raised by the reviewers still stand,” and they were retracting the article.

HPV Article Withdrawn Without Detailed Explanation by Journal of Toxicology and Environmental Health

  • Mon, Jan 13, 2020 - 05:12pm

    #95

    sand_puppy

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    Flu Vaccine Updates

The 4th quarter 2019 Vaccine Court Settlement summary statement has been released (here).   For this 3 month period,  181 of the 395 cases submitted were compensated.  The harming vaccine and diagnosis are listed in the report for 110 (but not all) of these 181 cases.  I am not sure why some cases are not listed.

27 cases of Guillian-Barre Syndrome (GBS), most from the flu shot.

16 cases of other central nervous system inflammatory conditions (like transverse myelitis, chronic inflammatory demyelinating polyneuropathy, acute disseminated encephalomyelitis)

For those unfamiliar, the Cochrane Collaboration is the closest thing that I know of to literature analysis that is unbiased by commercial and political forces.  I trust them.  Peter Doshi (here , here and here) and Tom Jefferson, senior epidemiologists and senior authors at the Cochrane Collaboration are particular heros of mine.

This year, they have decided to “stabilize” their three ongoing 20-year duration meta-analyses of the influence of the flu shot stating that there are currently no ongoing studies likely to affect their conclusions.  They will re-open analysis if a trial is launched that 1) uses a control group, 2) adheres to clear inclusion/exclusion criteria, or 3) that includes a robust model of influenza-like illness.

At this point in time, evidence that the flu shot offers benefits are very low.

.

How many people die each year of the the flu?

The CDC methods estimate 4,000 to 12,000 deaths from influenza are expected in the 2019-2020 winter flu season.  (Here)  Historically, the CDC uses the figures 4,000 – 36,000 / year.

The epidemiologists at Cochrane Collaboration are unimpressed with the CDC’s methods and dispute its conclusions.  [Definition:  the disease “influenza” involves the laboratory detection of influenza RNA in a patient who is clinically sick with an influenza-like illness (ILI) (fever, headache, body aches and cough).]

Tom Jefferson writes:

[T]here is no reliable system to monitor and quantify the epidemiology and impact of ILI, the syndrome that presents clinically. Few states produce reliable data on the number of physician contacts or hospitalized cases due to ILI, and none tie these data to the proportion of ILI caused by influenza. We do not know for certain what the impact of ILI is, nor the impact of the proportion of ILI caused by influenza. Prospective studies apportioning positivity to the scores of viruses probably causing ILI are rare, as interest is focused on influenza. The standard quoted figure of 36,000 yearly deaths in the US is based on the “respiratory and circulatory deaths” category including all types of pneumonia, including secondary to meconium ingestion (newborns) or bacterial causes of pneumonia [and sepsis].  More recently, the US Centers for Disease Control and Prevention (CDC) have proposed estimates of impact ranging between 3,000 and 49,000 yearly deaths. When actual death certificates are tallied, influenza deaths on average are little more than 1,000 yearly.  (source) So, the actual threat [of influenza] is unknown (but likely to be small) and so is the estimation of the impact of vaccination. (Source)

Tom Jefferson is the epidemiologist who did a meta-analysis of the Cochrane Collaboration placebo arms including 80,000+ patients with ILI .  He estimates that only 8% ILI were due to influenza.  (BMJ Clin Evid. 2009; 2009: 0911. “Influenza.”  Archives.)

In addition, the flu shot may worsen other respiratory viral infections.

The underlying assumption that influenza vaccination does not affect the risk of non-influenza [illness] is contradicted by a recent report from the follow up of a trial by Cowling et al.8 In 115 participants, those who received trivalent influenza vaccines had higher risk of acute respiratory infection associated with confirmed non-influenza respiratory virus infection (RR, 4.40; 95% CI, 1.31–14.8) compared to placebo recipients. The agents were mainly rhinoviruses and coxsackie/echoviruses. (Source)

The 3 long-term studies of influenza vaccine effectiveness by the Cochrane Collaboration can be found here.

It is probably not smart to talk with your doctor about this.  This topic lies outside the Overton Window and challenges a sacred orthodoxy.

  • Mon, Jan 13, 2020 - 05:22pm

    #95

    sand_puppy

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  • Mon, Jan 13, 2020 - 05:39pm

    #95

    sand_puppy

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    Flu shot quarterly harms report

The 4th quarter 2019 Vaccine Court Settlement summary statement has been released (here).   For this 3 month period,  181 of the 395 cases submitted were compensated.  The harming vaccine and diagnosis are listed in the report for 110 (but not all) of these 181 cases.  I am not sure why some cases are not listed.

  • 27 cases of Guillian-Barre Syndrome (GBS), almost all from the flu shot.
  • 16 cases of other devastating central nervous system inflammatory conditions (like transverse myelitis, chronic inflammatory demyelinating polyneuropathy, acute disseminated encephalomyelitis)

The three, 20-year ongoing studies of the impact of influenza vaccination done by the Cochrane Collaboration are here.

The Cochrane Collaboration epidemiologists are unimpressed with the effectiveness of the flu shot and point out that the magnitude of the flu threat as described by the CDC is unrealistic.  Most clinical influenza-like illnesses are not influenza.  Best estimates are 8% of ILI is truly influenza.

Tom Jefferson writes of this lack of clear evidence:

However there is no reliable system to monitor and quantify the epidemiology and impact of ILI, the syndrome that presents clinically. Few states produce reliable data on the number of physician contacts or hospitalised cases due to ILI, and none tie these data to the proportion of ILI caused by influenza. We do not know for certain what the impact of ILI is, nor the impact of the proportion of ILI caused by influenza. Prospective studies apportioning positivity to the scores of viruses probably causing ILI are rare, as interest is focused on influenza. The standard quoted figure of 36,000 yearly deaths in the US is based on the “respiratory and circulatory deaths” category including all types of pneumonia, including secondary to meconium ingestion or bacterial causes.  More recently, the US Centers for Disease Control and Prevention (CDC) have proposed estimates of impact ranging between 3,000 and 49,000 yearly deaths. When actual death certificates are tallied, influenza deaths on average are little more than 1,000 yearly.  (Source) So, the actual threat is unknown (but likely to be small) and so is the estimation of the impact of vaccination.

  • This reply was modified 1 week, 4 days ago by  Adam Taggart.
  • This reply was modified 1 week, 4 days ago by  sand_puppy.
  • Tue, Jan 14, 2020 - 05:23am

    #95

    sand_puppy

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    Peter Doshi on Flu vaccine: Medical Politics over Science

Peter Doshi’s Ph.D. thesis at MIT  is briefly reviewed here.  (full document available)  He argues that the US influenza vaccination policy is a triumph of politics (marketing) over science.  He reviews the way the disease has been marketed, and the minimal effect of the influenza vaccine.  Peter Doshi is a close associate of Tom Jefferson, senior author of the Cochrane Collaboration.  These two epidemiologist are strong critics of the role of influenza vaccination.

Influenza: A Study of Contemporary Medical Politics

By Peter N. Doshi

Abstract

Over the past decade, the prevention and control of seasonal and pandemic influenza has grown to be one of the largest and most visible public health policies. This dissertation considers contemporary influenza policy as a case study in what I call medical politics, in which a disease that for most people is rather unremarkable has become the focus of intense (and costly) public health campaigns based on a shaky scientific basis. The dissertation seeks to explain how this could happen.

 

The first two chapters show how influenza and its pandemics are marketed through an appeal to numerous scientific claims. Drawing on governmental marketing materials, statements by officials, and policy documents, I try to let officials speak for themselves and, as much as possible, refrain from analysis. Chapter 3 tells the story of the 2009 novel influenza H1N1 outbreak, showing how official understandings about influenza were called into question by an outbreak far milder than experts had predicted, and discusses investigations which highlighted the role of industry in shaping influenza policy. Chapter 4 analyzes official scientific claims regarding influenza, and argues that degree to which influenza is a serious public health problem is actually unclear. Furthermore, influenza vaccine effectiveness has been vastly overstated, predictive models of pandemic influenza are demonstrably flawed, and officials conflate true influenza with influenza-like illness (ILl), an often overlooked but critical distinction which allows officials to mislead the public into holding false assumptions about the potential benefits of influenza vaccine.

  • Tue, Jan 14, 2020 - 05:38am

    #96

    sand_puppy

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  • Tue, Jan 14, 2020 - 05:47am

    #96

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