Thailand: a Country-level COVID-19 Experiment
People with bleeding disorders or low blood pressure should not use the plant or its compounds without consulting with their health care professionals. It’s also recommended to avoid using the herb if you are on medications for slowing blot clots, including aspirin, ibuprofen and warfarin.
Interesting – if andrographis should be avoided if you are taking anti-clotting medications, that does suggest in addition to the TMPRSS2 effects, it might actually help address the clotting that causes so much trouble in COVID.
Yes. Here. A “basic science” paper on AP:
Two new flavones, designated as andropaniculosin A (1) and andropaniculoside A (2), and 30 known compounds were isolated as a result of detailed chemical examination on the whole plants of Andrographis paniculata. Their structures have been elucidated mainly by 1D and 2D NMR, and MS spectroscopic methods. Among them, four flavonoids showed potent inhibition of collagen, arachidonic acid, thrombin, and platelet activation factor induced platelet aggregation. Furthermore, a diterpenoid demonstrated moderate vasorelaxing effect in isolated rat thoracic aorta.
Note this was just “the components” of the herb, rather than some trial that showed this same result.
So if I’m getting this right, androgenic activity increases TMPRSS2 expression or activity, so lowered androgenic activity reduces the virus’ ability to bind to ACE2.
The side effect being reduced androgenic activity, i.e. reduced masculinity/manliness, but with a possible androgen receptor upregulation response. So I bet they’ll try approve it if it makes men more effeminate, or suppress it if it causes androgenic upregulation i.e. makes men more masculine.
Why proxalutamide and not any of the other antiandrogens though? Stronger antagonism than the others? Is it cheaper?
And andrographolide might be even better as it “may bind to a spectrum of protein targets including NF-kB” and IL-6, thus inhibiting inflammation.
Bromhexine, Dutasteride, Finasteride, and Spironolactone are fairly available in the USA.
Yes, but the 5-alpha reductase inhibitors (-asteride) only inhibit DHT production, still leaving T and the other androgens to agonize androgen receptors. I’d also rather somewhat block receptors than create an imbalance in the ratios of steroid hormones, plus you might get androgen receptor upregulation.
Spironolactone’s antiandrogenic effect is secondary to its high antimineralocorticoid activity, so you’d be creating an unnecessary imbalance that would affect your electrolyte balance and other things (one of them is that the opposite sex wouldn’t detect you pheromonally, LOL).
Bromhexine looks good though, so long as you don’t inhibit your mucus production too much. If you have virus in your upper respiratory tract, you want to push it down into the stomach acid.
Hmmm… quite a mystery.. I mean it’s not like any doctor has reported that 65% of his vaccinated patients had elevated tropinin levels, right? Oh, wait..
— Dr Clare Craig (@ClareCraigPath) July 31, 2021