Thailand: a Country-level COVID-19 Experiment

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  • Wed, Jul 28, 2021 - 11:37am

    #1
    davefairtex

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    Thailand: a Country-level COVID-19 Experiment

So this is one I’ve been watching.

A while back, Thailand ran this tiny trial on Andrographis Paniculata, which is also called Green Chiretta, for COVID-19.   The in-silico study looked good (seemed better than hydroxychloroquine), the in-vitro study looked good, and the tiny trial also looked positive.  I posted on it, months back.  Here’s the RCT:

https://www.medrxiv.org/content/10.1101/2021.07.08.21259912v1.full-text

Pneumonia occurrence during illness was:
APE 0/29 (0%) versus placebo 3/28 (10.7%), (p=0.039);
and patients with nasopharyngeal SARS-CoV-2 detection on Day 5 were
APE 10/29 (34.5%) versus placebo 16/28 (57.1%), (p=0.086).

In the tiny trial (n=58), APE prevented progression to pneumonia, and had a trend to viral clearance.

Then, “Delta” struck Thailand – for real.  The government imposed the usual: Lockdowns.  Mask mandates.  “Field hospitals” – if you test positive, you are (no choice now) “checked in” to a field hospital (think: sports stadium with beds) with 3000 other mild/asymptomatic people.  No choice – that’s where you go.   If you are rich, you can pay for a “hospitel” room – $100/day.  Again – no choice: field hospital or “hospitel.”  How’s that for an incentive to being tested?  The government used a version of “the CCP strategy.”  This didn’t have any noticeable effect at all on cases, which continued to scream higher.

[Note too this outbreak happened concurrently with a vaccination drive.  Outbreaks and vaccination do seem to go together.  Curious, that.  I digress.]

And then – a curious chain of events took place.  The government decided to run a large experiment:  “The Corrections Department gave green chiretta to about 11,800 infected inmates, she said, and 99.02% of them recovered.”  Note: more than this, we have not been told.

Afterwards, the cabinet approved its use.  (Note: not the FDA – the Cabinet; I’m guessing that’s local politics).  Prior to this, Andrographis was available OTC – it is apparently a local cold & flu remedy.  Cost: $2.50 at the local convenience store.

https://www.bangkokpost.com/thailand/general/2155659

Now people are hoarding it:

https://www.chiangraitimes.com/health/thai-people-begin-hoarding-green-chiretta-to-ward-off-covid-19/

So does it work?

Just today, @jjchamie posted much of this series of events on his twitter feed – with the especially interesting point that Andrographis targets the “androgen receptor” (hey maybe that’s what the “andro” meant?) – and @jjchamie wonders if Andrographis could be an herbal version of “proxalutamide.”  A reminder: proxalutamide has proven to be more effective than ivermectin the 4 RCTs it has been tried in.  Did I mention that Andrographis costs $2.50 and is (or at least was) available at 7-11?

https://pubmed.ncbi.nlm.nih.gov/21442031/

Andrographolide, an herbal medicine, inhibits interleukin-6 expression and suppresses prostate cancer cell growth

Oh yeah, it seems to help prostate cancer too.  But that’s yet another story for another time.

So at this moment, there is a massive, country-wide experiment going on.  Everyone has heard about this substance at this point.  This substance has perhaps the least RCT evidence of any item I’ve seen, and the widest national adoption.  I have heard stories of people, who were forced to be tested (they were close contacts – no choice now – must be tested, and if positive => field hospital for 14 days), and they didn’t want to go to the field hospital (would you?), so they took Andrographis as prophylaxis.

Search queries for Andrographis peaked about a week ago.  If things go the way they went in Indonesia (cases in Indonesia peaked 14 days after the “Ivermectin” search term peaked), we could see Thailand’s cases peak out in a week.

If this happens, then we’ll have a strong clue that we have a new substance we can use in our struggle against COVID19.  In fact, it could be the most effective substance ever.  Why do I say this?  Look at the c19early on proxalutamide.  And did I mention this costs $2.50 at 7-11???

https://c19early.com/

You can get this substance too.  You don’t have to fly to Thailand.  It costs around $10-$20.  The dosing is the only thing that needs to be sorted out.  And apparently the plant is not difficult to grow.

The twitter feed from @jjchamie that lays much of this out:

https://twitter.com/jjchamie/status/1420193329795543046

  • Wed, Jul 28, 2021 - 11:53am

    #2
    Mike from Jersey

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    Thailand: a Country-level COVID-19 Experiment

Dave,

Shame on you.

You are going to hurt Big Pharma sales.

I just called Anthony Fauci.

He said he was going to name you an enemy of the state.

  • Wed, Jul 28, 2021 - 12:01pm

    #3
    Pappy

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    Thailand: a Country-level COVID-19 Experiment

Good info here, DF. Thanks.

  • Wed, Jul 28, 2021 - 12:11pm

    #4
    Friedrichs_teeth

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    Thailand: a Country-level COVID-19 Experiment

I just did a search of autographis and I got a lot of hits. But on closer inspection it turns out that “autographis” is a word included in the latin gibberish when you are creating a site (and the latin text represents the content that doesn’t exist yet).

When I refined the list it turns out AOR has a bottle of it.  https://aor.ca/product/andrographis/

Since I am in Canada and they have blocked all access to Ivermectin, I am going to buy this right now to ensure I have things that I can use if the government shuts down more covid treatment items.

  • Wed, Jul 28, 2021 - 12:52pm

    #6

    Jim H

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    JChamie twitter link

Thanks Dave,  Excellent post.  I will be buying some.. dirt cheap stuff too.

  • Wed, Jul 28, 2021 - 12:58pm

    #7

    sand_puppy

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    Androgen blockers in COVID

Thanks Dave,

As a non-herbal-trained guy, I have a hard time feeling like I could grow a plant and harvest it at the optimum time and make a tincture or extract.  Maybe it isn’t so hard if you know about it!

And Proxalutamide is not available in the USA or Canada.  It is made in China by Kintor Pharmaceuticals.

Used in studies in Brazil.  Approved for compassionate use in Paraguay.  In phase III studies in the USA.  Not available in Europe.

Good diagram of the mechanism of action of an anti-androgen medication–comes back to the enzymes that snip the polybasic (furin) cleavage site between S1 and S2 on the spike protein.  In this case, the enzyme is TMPRSS2.

Source here.  Includes alternative meds that inhibit TMPRSS2

Bromhexine, Dutasteride, Finasteride, and Spironolactone are fairly available in the USA.

Several other androgen receptor blockers are available (but expensive!)  from the blue lettered list on the left side of the diagram that are being used for prostate cancer.

Bromhexine is over-the-counter but is a bit hard to find.  eBay has quite a few brands of bromhexine available.

 

  • Wed, Jul 28, 2021 - 01:26pm

    #8
    Friedrichs_teeth

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    Thailand: a Country-level COVID-19 Experiment

Very interesting. I am trying to understand how all these things interact with covid and which could in turn help my health as well. As an anti-androgen could chiretta also reduce PCOS? It seems like a theory.

I have no problem supplementing with essential vitamins and minerals. It seems to me if you are low in something your body uses to function then you should do what you can to increase those stores. Herbs are a little scary for me. It is like drugs without the long patient insert forms. Although I guess if I look at it that way so is food.

  • Wed, Jul 28, 2021 - 01:51pm

    #9
    Clem

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    Thailand: a Country-level COVID-19 Experiment

Dave,

Thanks for sharing!

Here is a suggestion on dosing from Dr Axe –

https://draxe.com/nutrition/andrographis/

Dosage

In traditional medicine, the leaves, stem and root of andrographis were used to create tinctures, teas, powders, juices and pastes. These formulas were ingested or applied topically to improve a range of conditions, from intestinal worm infestation to eczema, gonorrhea and infected wounds.

Today, popular forms of andrographis include capsules, extracts, tinctures and teas. There is no single recommended dose for the plant or its compounds, but various doses have been studied.

For the common cold, one report suggests a “reasonable dose regimen” of a 300-milligram tablet, four times daily, for the first few days of symptoms.

For fever reduction and relief from inflammatory issues or pain, taking a higher dose of three to six grams daily is typically recommended.

Another common dose for ulcerative colitis and issues related to inflammation is 1,200–1,800 milligrams of andrographis extract per day for eight weeks.

To determine the right dose for your needs, speak to your naturopathic doctor or health care professional.

Risks and Side Effects
Andrographis is not recommended for children or women who are pregnant or nursing. If you have autoimmune disease, speak to your health care provider before using andrographis, as it works to stimulant the immune system and may increase symptoms.

People with bleeding disorders or low blood pressure should not use the plant or its compounds without consulting with their health care professionals. It’s also recommended to avoid using the herb if you are on medications for slowing blot clots, including aspirin, ibuprofen and warfarin.

Conclusion

  • Andrographis is an herb that’s been used for thousands of years in traditional and folk medicine.
  • It’s been used for a range of health conditions, including respiratory tract infections, fever, digestion, diabetes, pain, inflammatory conditions and cancer.
  • There’s no recommended dose for andrographis, as the proper amount depends on your health needs. The typical doses range from 1,200 milligrams to six grams per day.
  • Andrographis is available in tea, capsule, tincture and extract forms.
  • Wed, Jul 28, 2021 - 07:11pm

    #9
    MGRS

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    Thailand: a Country-level COVID-19 Experiment

Thanks for the info Dave – you posted about this stuff a few months ago, and I picked up a bottle then. Can’t wait to see the results of this “trial.”

Once again, PP might put us ahead of the curve.

  • Wed, Jul 28, 2021 - 09:13pm

    #10
    Friedrichs_teeth

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    Thailand: a Country-level COVID-19 Experiment

Darn. About the autoimmune disorder warning.

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