SC2 vulnerability: it might be all about Glutathione

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  • Sun, Jul 12, 2020 - 11:12am

    #1

    davefairtex

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    SC2 vulnerability: it might be all about Glutathione

Glutathione is a critical antioxident that your body produces; unfortunately as you age, it will produce less and less as time goes on.  In addition, some conditions (obesity, diabetes, cardiovascular disease) result in lower than normal glutathione levels.

Notice that these are the same co-morbidities that make you vulnerable to a severe experience with SC2.

The following paper hypothesizes that the common denominator underlying all “bad experiences” with COVID-19 have to do with  glutathione deficiency.  This theory explains why young people are relatively immune (they typically have high glutathione levels naturally) and why older people tend to have more problems (glutathione production drops as you get older – dropping off quite substantially in the elderly), and that all those “co-morbidities” often result in low glutathione levels also:

https://pubs.acs.org/doi/10.1021/acsinfecdis.0c00288

Higher rates of serious illness and death from coronavirus SARS-CoV-2 (COVID-19) infection among older people and those who have comorbidities suggest that age- and disease-related biological processes make such individuals more sensitive to environmental stress factors including infectious agents like coronavirus SARS-CoV-2. Specifically, impaired redox homeostasis and associated oxidative stress appear to be important biological processes that may account for increased individual susceptibility to diverse environmental insults. The aim of this Viewpoint is to justify (1) the crucial roles of glutathione in determining individual responsiveness to COVID-19 infection and disease pathogenesis and (2) the feasibility of using glutathione as a means for the treatment and prevention of COVID-19 illness. The hypothesis that glutathione deficiency is the most plausible explanation for serious manifestation and death in COVID-19 patients was proposed on the basis of an exhaustive literature analysis and observations. The hypothesis unravels the mysteries of epidemiological data on the risk factors determining serious manifestations of COVID-19 infection and the high risk of death and opens real opportunities for effective treatment and prevention of the disease.

Turns out, fixing glutathione deficiency has been explored at length by a researcher at Baylor.  You can see the course of his research over time, below.  According to his studies, it is neither hard, nor expensive, to remedy glutathione deficiency.  The two chemicals he uses in his trials [NAC, and Glycine] are available over the counter.  Note: both NAC and glycine do have interactions with some other medications; you might want to check these out before embarking on a personal terrain improvement project, as well as viewing the research and consulting with your doc, etc.  This post is not to be mistaken for specific medical advice!

https://www.researchgate.net/scientific-contributions/10063374_Rajagopal_V_Sekhar

Here’s a paper that describes just how critical glutathione (GSH) is, and how low glutathione levels occur in nearly all major human diseases.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756154/

Changes in GSH levels and/or oxidation state have now been reported in nearly all major human diseases. Although in many cases these changes likely occur as a result of the underlying disease progression, in other cases these changes are closely linked to the onset and/or development of the disease. ….  In addition, the recognition that GSH is intimately involved in so many disease states has generated considerable interest in identifying therapies aimed at modulating GSH levels so as to modulate disease risk or progression. Although such therapies have significant hurdles to overcome, they offer significant promise for many human diseases.

  • Mon, Jul 13, 2020 - 02:38am

    #2

    davefairtex

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    aging, GlyNAC, and glutathione

Here’s some more research by Sekhar on “GlyNAC” supplementation and its effects.  I’m not qualified to assess how important the “reduction in oxidant damage” is; all I know is that glutathione levels were restored via his supplement regime.

First study, n=16:

http://ajcn.nutrition.org/content/94/3/847.long

Supplementing the diets of elderly humans with these amino acids for 14 d
stimulated glutathione synthesis to rates comparable with those of younger subjects and restored intracellular concentrations. This in turn was associated with a significant reduction in oxidant damage.

And another, a small RCT, n=36, 16-week study, ended November 2019.  Full study wasn’t available – at least that I could find.

https://www.researchgate.net/publication/337144252_CORRECTING_GLUTATHIONE_DEFICIENCY_AND_MITOCHONDRIAL_DYSFUNCTION_IN_OLDER_HUMANS_A_RANDOMIZED_CLINICAL_TRIAL

GlyNAC supplementation in older-humans significantly improved and restored MFO; increased gait-speed (19%,) and physical-function; and decreased oxidative-stress (TBARS 80%), inflammation (IL-6 83%; TNF-alpha 58%), and insulin-resistance (HOMA-IR 68%), but young-controls were unaffected. These data provide proof-of-concept that GlyNAC supplementation could improve the health of older-humans by correcting Glutathione-deficiency and mitochondrial-defects to improve gait-speed, oxidative-stress, inflammation and insulin-resistance.

  • Mon, Jul 13, 2020 - 09:52am

    #3
    Mohammed Mast

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    Reply To: SC2 vulnerability: it might be all about Glutathione

I suggest a visit to Medcram. Dr. Seheult goes into this pretty deeply.

https://www.medcram.com/courses/take/coronavirus-outbreak-symptoms-treatment/lessons/12847745-update-70-glutathione-deficiency-oxidative-stress-and-covid-19

  • Mon, Jul 13, 2020 - 01:10pm

    #4

    gallantfarms

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    Glutathione – Don’t Take Tylenol!

One very important thing people need to know is that acetaminophen (Tylenol) can drastically deplete glutathione.  So if you are taking tylenol when you are feeling sick that is about the WORST thing you could do!

Also, I would like to point out that NAC, which increases glutathione has been on Chris M’s list of recommended supplements for several months now.  NAC also thins mucus and has been popular for people with sinus and lung issues.

Dr. Michael Murray wrote an article on this here:

Lower levels of glutathione results in the combination of an impaired immune response, decreased protection against the virus and cellular damage, and an increased inflammatory response. The bottom line is that if you want to survive this pandemic, you need to take steps to boost your glutathione stores and definitely avoid drugs like acetaminophen that can cause glutathione levels to plummet.

—–

There are a number of strategies to boost glutathione levels. For prevention of COVID-19, one of my recommendations is to take N-acetylcysteine. It not only boosts glutathione levels in the entire respiratory tract and lungs, it also is a mucus modifying agent that helps the protective mucus in blocking viruses. NAC helps to reduce the viscosity of bronchial secretions and improves airway and lung function. For general protection and boosting glutathione levels, I recommend a dosage of 500 to 1,000 mg daily. For use in reducing mucus thickness, the typical dosage is 200 to 400 mg three to four times daily.

  • Mon, Jul 13, 2020 - 05:23pm

    #5
    kunga

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    SC2 vulnerability: it might be all about Glutathione

Thank you for Tylenol info, gallantfarms.

When I was at Mayo Clinic for hip operation and later at rehab center, the only pain killers offered were Tylenol (with Tramadol) or Oxycodon. I was not going to take an opioid, no matter what.  Tylenol never worked for me.  Luckily, I  snuck in a supply of Aleve which always cuts my pain.  When you are in the hospital, they really push the Tylenol, must be a financial deal.  I hope to stay away from hospitals and nursing homes where you are a virtual prisoner.

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