SARS-Cov vaccine leads to Pulmonary Immunopathology when exposed to virus 2012

Login or register to post comments Last Post 0 reads   4 posts
  • Thu, Sep 03, 2020 - 07:44am

    #1
    Hohhot

    Hohhot

    Status Bronze Member (Offline)

    Joined: Mar 12 2020

    Posts: 69

    count placeholder2

    SARS-Cov vaccine leads to Pulmonary Immunopathology when exposed to virus 2012

April 12, 2012

Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with SARS Virus

Chien-Te Tseng, Elena Sbrana, Naoko Iwata-Yoshikawa, Patrick C. Newman, Tania Garron, Robert L. Atmar, Clarence J. Peters, Robert B. Couch

Results

All vaccines induced serum neutralizing antibody with increasing dosages and/or alum significantly increasing responses. Significant reductions of SARS-CoV two days after challenge was seen for all vaccines and prior live SARS-CoV. All mice exhibited histopathologic changes in lungs two days after challenge including all animals vaccinated (Balb/C and C57BL/6) or given live virus, influenza vaccine, or PBS suggesting infection occurred in all.  Histopathology seen in animals given one of the SARS-CoV vaccines was uniformly a Th2-type immunopathology with prominent eosinophil infiltration, confirmed with special eosinophil stains. The pathologic changes seen in all control groups lacked the eosinophil prominence.

Conclusions

These SARS-CoV vaccines all induced antibody and protection against infection with SARS-CoV. However, challenge of mice given any of the vaccines led to occurrence of Th2-type immunopathology suggesting hypersensitivity to SARS-CoV components was induced. Caution in proceeding to application of a SARS-CoV vaccine in humans is indicated.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035421

 

Some corrections were made to table figures in August.

https://journals.plos.org/plosone/article?id=10.1371/annotation/2965cfae-b77d-4014-8b7b-236e01a35492

  • Thu, Sep 03, 2020 - 08:29am

    #2

    Jim H

    Status Bronze Member (Offline)

    Joined: Jun 08 2009

    Posts: 1206

    count placeholder4

    Thank you Hot…

I was dumb enough to take two of the three recommended doses of the Lymerix vaccine in the late 90’s.  I won’t do that again;

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2870557/

These findings suggested that, in patients with the DR4+ genotype, an immune response against OspA could translate into a cross-reactive autoimmune response. By implication, an OspA Lyme vaccine might result in autoimmunity in these genetically predisposed individuals. Although causality proved difficult to demonstrate, one study reported four male patients with the DR4+ genotype who developed autoimmune arthritis after receiving LYMErix™ vaccine [34].

  • Thu, Sep 03, 2020 - 06:03pm

    #3
    nordicjack

    nordicjack

    Status Silver Member (Offline)

    Joined: Feb 03 2020

    Posts: 728

    count placeholder1

    SARS-Cov vaccine leads to Pulmonary Immunopathology when exposed to virus 2012

But we have a safe and effect Cov 2 vaccine.   really? ready to go Nov?   But no one has challenged the vaccinated subjects.. Really? is there plan to kill millions?  I can tell you , I am no where near a vaccine.. I would take hypogonadism first.. thank you.

  • Fri, Sep 04, 2020 - 08:18am

    #4
    tbp

    tbp

    Status Gold Member (Offline)

    Joined: Apr 12 2020

    Posts: 521

    count placeholder1

    SARS-Cov vaccine leads to Pulmonary Immunopathology when exposed to virus 2012

Which threat is biggest:

-SARS-CoV-2

-Big Pharma cartel and governments’ threats to force inocculate you with highly weaponized vaccines?

Even if we didn’t have effective cures, I’m not sure the virus itself would be the biggest threat.

Viewing 4 posts - 1 through 4 (of 4 total)

Login or Register to post comments