Prions, Neurodegeneration, and Niacin

Login or register to post comments Last Post 0 reads   19 posts
Viewing 10 posts - 1 through 10 (of 19 total)
  • Sun, Oct 24, 2021 - 12:15pm

    #1
    davefairtex

    davefairtex

    Status Member (Offline)

    Joined: Sep 03 2008

    Posts: 2882

    count placeholder23

    Prions, Neurodegeneration, and Niacin

Researchers at Scripps came up with a “prion model” – using this nasty substance TPrP (a “misfolded protein”) which, when added to neuronal cells, ends up killing them off after a number of days.  Then they tried to figure out why:

  • prion-infected neuronal cells didn’t die due to apoptosis (a sort of cellular suicide)
  • the primary cause of neuronal cell death: acute NAD+ deficiency
  • when they supplemented the cells with NAD+, this rescued the dying cells and mitigated neurodegeneration.
  • they used both in-vitro experiments, as well as a mouse model.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840455/

Neuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment

Toxic prion protein-exposed neuronal cells exhibit dramatic reductions of intracellular NAD+ followed by decreased ATP production, and are completely rescued by treatment with NAD+ or its precursor nicotinamide because of restoration of physiological NAD+ levels.

Translation: Niacin fixes prion-driven neurodegeneration!!

What’s a prion-driven neurodegenerative disease?

“Prion diseases are fatal brain diseases of animals and humans and belong to the group of protein misfolding neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s diseases, frontotemporal dementia or amyotrophic lateral sclerosis. The common feature of these diseases is that their aetiology is linked to the misfolding and aggregation of a host protein.”

So why do we care?

Here’s a non-peer-reviewed paper that says the dreaded plague has a prion-like domain, located in the spike protein:

https://www.preprints.org/manuscript/202003.0422/v1

Compared with other viruses, a striking difference was observed in the distribution of prion-like domains in the spike protein, since SARS-CoV-2 was the only coronavirus with a prion-like domain found in the receptor-binding domain of the S1 region of the spike protein.

And of course all the spike-containing Holy Shots use a modified spike protein – retaining the prion-like domain.  Here’s a paper that shows an association between the AZ shot (vs the Pfizer shot) and neurological effects possibly arising from the prion-like domain in the shot:

https://www.scribd.com/document/518099744/Covid19-Vaccine-Associated-Parkinsons-Disease-a-Prion-Disease-Signal

COVID-19 Vaccine Associated Parkinson’s Disease, A Prion Disease Signal in the UK Yellow Card Adverse Event Database

My takeaway: post-vax, or post-COVID-infection (i.e. after exposure to the flock of prion-like-domain-filled particles), it would seem to be a good idea to assure that one has absolutely no NAD+ deficiency.

And the more rapidly this is addressed, the more NAD+ deficient neuronal cells will be rescued from possible prion-mediated cell death.

Niacin!!

  • Sun, Oct 24, 2021 - 12:35pm

    #2
    Canuck21

    Canuck21

    Status Platinum Member (Offline)

    Joined: Aug 10 2020

    Posts: 1001

    count placeholder4

    Prions, Neurodegeneration, and Niacin

“it would seem to be a good idea to assure that one has absolutely no NAD+ deficiency.”

How does one make sure of this?

  • Sun, Oct 24, 2021 - 12:37pm

    #3
    sand_kitty

    sand_kitty

    Status Member (Offline)

    Joined: Apr 13 2011

    Posts: 2000

    count placeholder8

    Prions, Neurodegeneration, and Niacin

What a finding and synthesis, DaveF!!

I am relieved that nicotinamide was effective as it is readily available and doesn’t cause that flushing (which I do NOT enjoy)!  (Nicotinamide MonoNucleotide–NMN)

I learned more about the scope of this amazing molecule here.

  • Sun, Oct 24, 2021 - 01:17pm

    #4
    davefairtex

    davefairtex

    Status Member (Offline)

    Joined: Sep 03 2008

    Posts: 2882

    count placeholder11

    nicotinamide

Canuck-

Anything that’s a NAD+ precursor should help for this purpose.  This includes NA, NAM, NMN, and NR.

SP – I’m pretty sure our intrepid prion researchers just used nicotinamide (= niacinamide = NAM), rather than the vastly more expensive NMN (nicotinamide mononucleotide).

As you know, flush niacin does have other benefits – cholesterol, and M1-M2 repurposing (like ivermectin).  But…”some people” don’t like the flush.  So “No Flush Benefits For You!” 🙂

If I had to guess, many if not all of the fantastic virtues ascribed to the pricey NMN also apply to the much cheaper NAM.  Its just that NAM doesn’t have a marketing arm, while NMN (and NR) both appear to have one.  I read the paper – at least half of it.  Kinda funny – their diagrams just don’t include NAM, even though that’s a main component of the “salvage pathway.”  Gosh I wonder why?

NMN: $48 for 250mg x 60 (15g)

https://www.walmart.com/ip/Genex-100-Pure-NMN-Supplement-250mg-per-Serving-Boost-Nad-Levels-60-Veggie-Capsules/829832288

NAM: $8 for 500mg x 100 (50g)

https://www.iherb.com/pr/solaray-niacinamide-500-mg-100-vegcaps/70058

NAM: $23 for 500g powder (500g)

https://www.bulksupplements.com/products/vitamin-b3-niacinamide?variant=32133465178223

  • Sun, Oct 24, 2021 - 01:44pm

    #5

    SagerXX

    Status Gold Member (Offline)

    Joined: Feb 11 2009

    Posts: 759

    count placeholder11

    Hot damn, DF!

You’re a freaking INFO NINJA!

many thanks for all the fine information and material you contribute to this community, but this one hits home especially for me, since I may have a predisposition towards Parkinson’s, which killed my father.

Happily, I have been scarfing flush niacin daily since you first brought the information to our attention, so here’s hoping it’s got a preventative effect! In addition, of course, to all the other salutary effects!

VIVA— Sager

  • Sun, Oct 24, 2021 - 02:25pm

    #6
    Guinify

    Guinify

    Status Member (Offline)

    Joined: May 23 2021

    Posts: 16

    count placeholder8

    Prions, Neurodegeneration, and Niacin

Thank you! This news brightened up my day. My husband was jabbed early (and is now one of the few jabbed people I know who’s anti-jab and actively encourages people to not get it). He’s been taking Niacinamide  (500 mg three times a day) for several months. He was about to sign himself up for surgery to “correct” nerve pain and inflammation when I finally convinced him to give niacin a chance. He’s now a complete believer in niacin and has even sent bottles to family members with similar issues. We have used both Nature’s Way (about $8 for 100, as noted above) and bulk from Bulk Supplements.

If you order larger quantities from Bulk Supplements, it ships in separately sealed bags, which is nice for storage. We got a kilo and it shipped in 5 individually sealed bags.

  • Sun, Oct 24, 2021 - 03:07pm

    #7
    davefairtex

    davefairtex

    Status Member (Offline)

    Joined: Sep 03 2008

    Posts: 2882

    count placeholder10

    my goal

My goal is to keep all my jabbed friends healthy – as well as all my COVID-recovered friends too.  These gp120-infested spikes just aren’t great for health.

Old Doc Fauci – and his higher-ups – have a lot to answer for.

Still, in the silver lining department, I know a LOT more about health situations now than I did 18 months ago.

  • Sun, Oct 24, 2021 - 05:07pm

    #8
    You've been Nudged...!

    You've been Nudged...!

    Status Gold Member (Offline)

    Joined: Aug 28 2021

    Posts: 538

    count placeholder2

    Prions, Neurodegeneration, and Niacin

Dr. Kevin W. McCairn Ph.D. noted the neurological aspects of COVID-19 as far back as January 2020 & has been following developments since….

His conclusions are that there are no safe levels of prion activity in the body – but not everyone will succumb to its effects.

Also, a prion-producing virus is the ‘holy grail’ of bioweapons – but would also likely lead to an extinction level event.

https://www.mccairndojo.com/

  • Sun, Oct 24, 2021 - 05:23pm   (Reply to #4)

    #9
    Canuck21

    Canuck21

    Status Platinum Member (Offline)

    Joined: Aug 10 2020

    Posts: 1001

    count placeholder3

    Prions, Neurodegeneration, and Niacin

Hi Dave, I meant how do you know when you have enough in your body? can you test your levels or do you go by how you feel?

  • Sun, Oct 24, 2021 - 05:37pm

    #10
    brushhog

    brushhog

    Status Platinum Member (Offline)

    Joined: Oct 06 2015

    Posts: 992

    count placeholder2

    Prions, Neurodegeneration, and Niacin

So which one gives you the flush? Im confused by the seemingly endless ‘types’ of niacin.

Viewing 10 posts - 1 through 10 (of 19 total)

Login or Register to post comments