Niacin: NAD+, Histamine, Inflammation, Serotonin, and COVID
Ever since the cranky Dr Kats staged his brief visit, I have been looking for clues about niacin.
I found that niacin addresses depression and anxiety. (Bill W found that out 60 years ago.)
Niacin (niacinamide) also addresses rheumatoid arthritis. (Hoffer also found this out – 70 years ago.)
Niacin also appears to prevent alzheimers – in the same way vitamin D prevents COVID, in that niacin deficiency is associated with a much faster progression into dementia. Niacinamide appears to reverse mild alzheimers – in mice. Of course this was never followed up with any trial. [Hello, $56k/year treatment recently approved by FDA!]
Flush niacin also can be used to abort migraine headaches. (from case reports – not a study)
Niacin also replenishes NAD+ – which is likely a part of why it is helpful in these other conditions.
So what’s its role in COVID19?
First – Dr Chetty and his success treating 4000 patients using his “day 8 therapy”, primarily with antihistamines.
It turns out, niacin is an antihistamine. Mast cells store histamine, and they release the histamine when allergens appear. And niacin clears histamine from mast cells. That’s part of the flush.
And there’s Fluvoxamine the SSRI, with deals with serotonin in the platelets, which is apparently a problem in COVID.
It turns out, Niacin also releases serotonin from platelets as part of the flush also.
Niacin-induced “Flush” Involves Release of Prostaglandin D2 from Mast Cells and Serotonin from Platelets: Evidence from Human Cells in Vitro and an Animal Model
And then there was – perhaps Dr Kory – who said recently that part of Ivermectin’s method of action controlling the cytokine storm was that ivermectin switches macrophages from “M1” (inflammatory) state to “M2” (anti-inflammatory) state.
Turns out, Niacin does this too. They studied niacin on Parkinsons patients; 3 months @ 250 mg/day not only helped the patients improve quality-of-life score, it also changed those macrophages from “M1” to “M2” also. Just like ivermectin.
Upregulation of GPR109A in Parkinson’s Disease
Maybe – the severe COVID reaction is, as Dr Chetty says, a “sensitivity reaction” to those lab-created viral particles. Plus, some sort of unpleasantness with the platelets & serotonin that I’m less familiar with.
And the fake spike proteins cranked out by the vax may cause the body to react in much the same way – histamine release, inflammation, possibly serotonin & platelets too. No data on that – but the side effects would seem to point in that direction.
Here are 3 case reports – somewhat on topic:
1) friend of mine was taking 1g niacin per day. flush was mild. He got the PFE shot. At some point post-vax, his niacin flush grew to be incredibly painful. He had to stop his niacin. Three weeks later, he tried the niacin again, and things were much better. He had no side effects from the shot. Theory: his painful flushes were the result of a massive histamine reaction, caused by all those fake spike proteins.
2) another friend of mine is taking niacinamide, 1.5g/day. He got the AZ shot. He had no side effects at all, not even a sore arm. He was worried he “got placebo.” That, or: Niacinamide may be a histamine inhibitor: https://www.karger.com/Article/Abstract/231550
3) third friend of mine was taking niacin for depression. He noticed that whenever he did, his allergies would be cleared up – his stuffy nose would vanish.
So in addition to its well-known effects in replenishing depleted NAD+ (part of the critical glutathione cycle), flush niacin appears to clear histamine (partly like an antihistamine), it turns the macrophages from an inflammatory state (M1) into an anti-inflammatory state (M2) (partly like ivermectin), and it releases serotonin from the platelets (partly like an SSRI).
Now all we need to do is add NAC to complete that glutathione cycle.
Which, it turns out, Dr. Kats has already done.
Not medical advice – its just my current theory. Sure would be nice to have a trial, wouldn’t it?
Now we just need to address the prion thing and we’ll be all set. 🙂
Flush Niacin + NAC?
Now we know why they’re out to ban NAC….
Thank you for tying all the research together Dave! The thing that irks me most about Kats these days is that he lashes out at anyone who won’t acknowledge him or his Niacin, including the good guys like Kory. He actually imagines they are in it for the $$ writing IVM scripts through telemed. Easy for him to say since he doesn’t have a medical license on the line for said $50 scripts.
He is a man child of the first order, but brilliant nonetheless.
Yeah he’s a pretty cranky guy. But relentless energy. And he keeps working the problem. He’s not wrong about Pharma, or the whole mess we’re in. He’s just one guy in the wilderness and that’s not so easy.
I think the thing I didn’t quite agree with was the initial “anti-viral” aspect. It just didn’t feel right. The anti-viral evidence just didn’t seem as compelling as – say – for HCQ, or Ivermectin. Or A. Annua. Or Andrographis, even.
So my sense – niacin is probably not as useful for phase 1. But phase 2? It really could be the bomb. I’d like someone to check my work and make sure I didn’t make any mistakes.
Oh, and one thing I’ve added to my own long-term niacin protocol: TMG. After several months on niacin, I started to have this craving for my beetroot juice. And another friend mentioned TMG in another context (was it post-vax prion management, maybe?), I looked it up and saw it was called “betaine” – from beet root – and it helped with methylation (which Kathy and QB both – I think – mentioned previously, w.r.t niacin), and so I ordered some, tried it, and when the craving dropped away – that settled it for me. TMG.
And it turns out TMG acts to reduce homocysteine, which is apparently problematic. Worse even than high cholesterol. Who knew?
Thanks Dave.. I was just reading up on the methylation/TMG supplement idea, and I came across this;
When taking Niacin, it’s a matter of balancing benefits, genetics, and need for compensatory support like TMG to keep the system in balance.
While researchers of NR are not concerned, others like Chris Masterjohn Ph.D., encourage those taking NR to consider a TMG supplement, or boost glycine intakes like that found in Collagen, Magnesium Glycinate, or L-glycine. Because Dr. Masterjohn is coming from a 3rd party perspective on the substance – I give his take a little more weight.
As it turns out, I take 500 mg Mg Glycinate every day… so I may already be doing a good job of balancing my (Niacin-induced) demethylation with a methyl donor, i.e. killing two birds with one supplement : )
Can you please explain more about the flush? I have searched “what is a niacin flush” so I get that, but are you deliberately aiming at getting one? Is it just to know that you have taken enough niacin? I would have thought that it would vary between individuals, when they get the flush.
Thanks, Dave, for all you do.
I have increased niacin, B3, in my morning anti aging/immune bone broth cocktail. Just call me, Baby Yoda. 🐱
I make refreshing Moranga mint sun tea for these brutal hot days of weed whacking and sagebrush killing. Sagebrush never sleeps.
I found some remaining N-Acetyl L Cystine at Swansonvitamins and lifeextension. Using it conservatively.
And JimH, thank you for all your research and links.
Yes, Dave, I was one of the TMG advocates, but it’s looking like I’m in overkill mode in that area. 1200 mg of glycine in my magnesium glycinate supplement plus TMG 1:1 with Niacin.
BTW, I’m the proud owner of 1.33 kg of NAC and considering buying more.
This is really interesting….. so do you think increasing niacin would help minimize asthma? I’m scientifically challenged so I’m rather lost on mast cells etc but I think allergies and asthma are related…. right? Also, how high of a dose would I need to take?
Asthma appears to be an inflammatory condition, in which histamine plays a role.
Histamine is an important mediator in airway inflammation. It is elevated in the airways of asthmatic patients and is responsible for many of the pathophysiological features in asthma.
One of my favorite sites is “doctor yourself.” It has ancient remedies from the 50s that the big drug companies are completely uninterested in people knowing about today.
Given that asthma is an inflammatory condition, it might benefit from niacin. And there’s the histamine release part too.
If I had asthma, I’d experiment on myself (see: “doctor yourself.”) But I would take personal responsibility for doing so. I would only use safe substances with 50-year track records. I’d make sure nothing I was taking interacted badly with my prescription medications. I’d write everything I do down, so I can see what things worked and what didn’t. And I’d start slow.
Here’s a case report on point I just found from google which suggests a synergy between C & niacin – see what you think about this lady’s story. It does seem to hang together.