NAC might be beneficial after all

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  • Fri, Oct 23, 2020 - 09:51am

    #1
    _Kevin Bell

    _Kevin Bell

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    NAC might be beneficial after all

MedCram Oct 23,2020 Title: Coronavirus Update 114: COVID 19 Death Rate Drops; NAC (N-acetylcysteine) Data

https://www.youtube.com/watch?v=eQO1PB8-xtg   Starts at 6:03

referenced study;  https://www.sciencedirect.com/science/article/pii/S1521661620306513

Kevin Bell / Alma, Arkansas

 

  • Fri, Oct 23, 2020 - 05:44pm

    #2
    Hohhot

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    NAC might be beneficial after all- additional info

Thank you for posting this. NAC helps make glutathione, considered a master anti-oxidant, and recycles vitamin C.

NAC in combination with Vitamin C if given IV prior to a procedure will protect the kidneys from damage by radiographic dyes.

https://cjasn.asnjournals.org/content/3/1/281

Additionally it is the only known treatment for acetaminophen overdose.

https://www.webmd.com/a-to-z-guides/tylenol-acetaminophen-poisoning

Beware the Pharma goons are looking to restrict/ban it.

https://www.lewrockwell.com/2020/09/joseph-mercola/fda-wants-to-ban-nac-now-that-it-combats-covid-19/

 

  • Fri, Oct 23, 2020 - 09:39pm

    #3
    nordicjack

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    NAC might be beneficial after all

FDA has been after NAC for a while…. even before COVID.     It is a legitimate therapeutic..   And like other nutraceuticals, actually is powerful medicine.   I am considering stock piling.

  • Fri, Oct 23, 2020 - 10:26pm

    #4
    DaveDD

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    NAC might be beneficial after all

Of course NAC is beneficial. It is a precursor of glutathione, the mother of all antioxidants. Maybe not as a preventative measure, but for sure to reduce impact, and most probably, not in the standard dose of 600mg. The focus on mortality and avoidance is imo extremely myopic. People tend to forget that 10% to 15% of the mild cases will have long term damage. High doses of antioxidants while ill will for sure reduce the damage. My personal experience (N=1). On my worst day I took over 150 grams of vitamin C, without bowel problems. Now I can take no more than 5 grams. Somewhere in my body that vitamin C was “consumed”. What kind of damage would have been occured without those antioxidants? I also took 4000mg of NAC per day…

In this case where we know that the worst case outcome is death, or, potentially long term damage, the old adage is true: “if it doesn’t kill you, it will make you stronger.”

  • Fri, Oct 23, 2020 - 10:47pm

    #5

    Jim H

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    Can anyone find the Niacin study referenced here?

Seems to be recent work in North Carolina, placebo controlled, showing outragreous efficacy using one gram per day Nicotinic acid supplement.  If anyone can find the root study please post;

  • Sat, Oct 24, 2020 - 12:47am

    #6

    davefairtex

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    NAC prophylaxis dramatically reduces flu symptoms

Elderly people taking 600 mg NAC 2xday were much less likely (25% vs 79%) to suffer symptoms from influenza infections.  Effectively, NAC turned many “symptomatic infections” of influenza into “asymptomatic infections” among the most vulnerable people.   Doesn’t that sound like a great outcome?  Especially if you are elderly?

https://pubmed.ncbi.nlm.nih.gov/9230243/

Both local and systemic symptoms were sharply and significantly reduced in the NAC group. Frequency of seroconversion towards A/H1N1 Singapore 6/86 influenza virus was similar in the two groups, but only 25% of virus-infected subjects under NAC treatment developed a symptomatic form, versus 79% in the placebo group. Evaluation of cell-mediated immunity showed a progressive, significant shift from anergy to normoergy following NAC treatment. Administration of N-acetylcysteine during the winter, thus, appears to provide a significant attenuation of influenza and influenza-like episodes, especially in elderly high-risk individuals. N-acetylcysteine did not prevent A/H1N1 virus influenza infection but significantly reduced the incidence of clinically apparent disease.

Can this work with COVID-19?    They are running studies, but they won’t finish until after the pandemic is over.  Of course.  No rush, guys.  Take your time.

We Are On Our Own.

https://clinicaltrials.gov/ct2/show/NCT04419025

You can get powdered NAC by the pound for about $50 – enough for a year’s supply.  Add it to your orange juice in the morning.  Warning: it’s sour.  I use about 2g/day.

https://www.bulksupplements.com/

“You can pry the NAC from my cold, dead fingers!”

  • Sat, Oct 24, 2020 - 08:24am

    #7
    tbp

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    Oxidants/ROS & antioxidants; NAC, vitamin C, H2, glutathione

Another factor to keep in mind is that the immune system uses radical oxygen species (ROS), such as hydrogen peroxide, superoxide and nitric oxide, to oxidize pathogens in localized places. As Dr. Mercola put it, “Hydrogen peroxide sits inside and outside of your cells in low levels, ready and waiting to be generated in greater amounts as soon as a pathogen is detected by your immune system”.

These ROS oxidants are neutralized by antioxidants, both those produced by the body (mainly catalase, superoxide dismutase, glutathione) and those you might take exogenously in food (smaller amounts) or as supplements (can be small but are usually taken in HUGE amounts). The body maintains a redox homeostasis or balance between oxidants and antioxidants. In cases of toxic insults (e.g. partying with excessive doses of MDMA, exposure to heavy metals or highly toxic drugs like paracetamol/acetaminophen, radiation exposure, etc), high doses of exogenous antioxidants (e.g. vitamin C and NAC) can be very useful, but in some cases of infection by pathogens, neutralizing that particular defense mechanism of the body COULD be counter-productive, as the mechanism of damage of the pathogen in most cases is not oxidative stress but rather something stronger (e.g. cell invasion and hijacking in the case of a virus).

Vitamin C is special in that it’s very non-toxic and in extremely high doses starts acting as an antiviral. I’m not sure how useful NAC is in high doses vs low doses (I like to take very low dose 100mg from time to time in liver cleansing supplement) under normal/healthy circumstances. To prevent glutathione depletion it’s extremely useful, and for respiratory infections in general, and to recycle vitamin C.

There’s another special antioxidant, molecular hydrogen (H2), that doesn’t affect the beneficial ROS, only the most toxic/unwanted ROS (peroxynitrates and hydroxyl radicals), while upregulating glutathione production. Chinese researchers already recommended H2 for treating Covid back in March. As Dr. Mercola explains: “Being the smallest molecule in the universe and having no polar charge, the hydrogen molecule is also able to diffuse through all cell membranes and subcellular compartments, including the nucleus and the mitochondria. It doesn’t need any transporters to do this, so it’s exceptionally bioavailable.” The main beneficial mechanism of action of H2 is its “ability to activate the Nrf2/keap1 pathway, thereby replenishing your endogenous antioxidants”. In this sense, “the absolute quantity of H2 is far less important than pulsing or creating an acute elevation of H2 in your system over a short period. That acute elevation is what activates the Nrf2 pathway. When exposure is continuous, even if elevated, it has virtually no effect.” In activating that Nrf2/keap1 pathway, H2 “helps regulate and maintain homeostasis in the whole system, preventing the infection from getting out of control and causing cell death”, by reducing peroxynitrites and hydroxyl radicals (produced by interaction of superoxide with nitric oxide). It “can also downregulate NOX and NOS enzymes, thus lowering superoxide and nitric oxide production respectively.” As a result, “your superoxide and nitric oxide are left to perform beneficial functions while the H2 eliminates the most dangerous byproducts of superoxide and nitric oxide, while simultaneously increasing your body’s natural production of antioxidants and regulating the enzymes that produce superoxide and nitric oxide.”

Interestingly, this “gives H2 a significant advantage over other antioxidants such as vitamin C, which act indiscriminately with superoxide and nitric oxide — both of which also have important and beneficial functions. H2 does not interact with either superoxide or nitric oxide. The only thing H2 can react with are the most dangerous ROS such as peroxynitrites and hydroxyl radicals.” This is also the reason why CDS (chlorine dioxide solution) should not be taken with vitamin C or other general-acting antioxidants, which will reduce significant amounts of any ROS before they can act beneficially against pathogens.

H2 is quite expensive for an antioxidant though.

It’s very funny that they try to convince us that chlorine dioxide is “bleach”, yet it’s the softest of all the ROSes, including those produced by our immune systems and those long used therapeutically like ozone (trioxygen). While they maintain the absurd idea that long-term blasting the body with chemo”therapy” cytotoxins is the only viable treatment for cancer, when you can just oxidize cancer cells with softer cytotoxins that are turned into useful nutrients (oxygen) by body enzymes once they’ve served their purpose. Look how visibly sick chemo patients get, and see if you can find anyone who ever got sick from CDS or ozone or exogenous hydrogen peroxide…

So probably the single best anti-Covid cocktail would be VitD+CDS+H2+ivermectin+HCQ+zinc+B3, without NAC or vitamin C, unless it’s an advanced case (i.e. used treatments late) in which H2 may not be enough to avoid glutathione depletion and vitamin C might get depleted too.

  • Sat, Oct 24, 2020 - 02:07pm

    #8
    DaveDD

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    NAC might be beneficial after all

Hi tpb,

Interesting information! I ordered some CDC. Unfortunately it arrived when I was ok again. Otherwise I would have experimented with it also (indeed making sure that no vitC was taken with it). I now have it at home. I tried it just for fun: it is utterly disgusting imo.

grts, Dave

  • Sun, Oct 25, 2020 - 12:54am

    #9
    Peggy

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    NAC might be beneficial after all

stockpiling… me too.

  • Sun, Oct 25, 2020 - 12:59am

    #10
    Peggy

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    NAC might be beneficial after all

tdp would you be so good as to translate what you wrote into normal English? There is a lot of good info in there, most of which I kindof but don’t really understand, but would like to!
Thanks

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