List of promising COVID-19 treatment protocols worldwide

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  • Tue, Sep 01, 2020 - 05:59pm

    #1
    cgarcia

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    List of promising COVID-19 treatment protocols worldwide

I created this thread to keep track of promising, experimental treatments for COVID-19 using repurposed drugs.

Interestingly, many or even most of the protocols come from developing countries since many people there are so poor that they can’t afford expensive treatments. Many of them use generic (patent expired) meds.

Please keep us posted if you find any other protocols.

  • Tue, Sep 01, 2020 - 06:03pm

    #2
    cgarcia

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    List of promising COVID-19 treatment protocols worldwide

The MATH+ protocol

The official website is this one:

Home

But strangely, the website is often down.

 

You can also find the full protocol here:

https://www.evms.edu/media/evms_public/departments/internal_medicine/EVMS_Critical_Care_COVID-19_Protocol.pdf

 

And the protocol summary here:

https://www.evms.edu/media/evms_public/departments/internal_medicine/Marik-Covid-Protocol-Summary.pdf

  • Tue, Sep 01, 2020 - 06:18pm

    #3
    cgarcia

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    List of promising COVID-19 treatment protocols worldwide

Austrailia triple therapy

Ivermectin + Doxycycline + Zinc

https://clinicaltrials.gov/ct2/show/NCT04482686?term=Ivermectin+borody&draw=2&rank=1

– Ivermectin on day 1 and day 4

– Doxycycline for 10 days

– Zinc for 10 days

Anyone has a link that shows the dosages used?

Both the treatment and placebo arms contain Vitamin C, Vitamin D and Zinc.

 

  • Tue, Sep 01, 2020 - 06:25pm

    #4
    cgarcia

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    List of promising COVID-19 treatment protocols worldwide

In Honduras, Central America, Dr Miguel Sierra-Hoffman devised the Catracho protocol comprising colchicine, anti-inflammatories, tocilizumab, ivermectin, blood thinners, and hydroxychloroquine. Anyone has a link that shows the dosages?

https://www.bbc.com/mundo/noticias-america-latina-52749761

Honduras: Catracho, the Covid-19 treatment method the country is using to reduce deaths within an impoverished health system

 

  • Tue, Sep 01, 2020 - 06:37pm

    #5
    cgarcia

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    List of promising COVID-19 treatment protocols worldwide

In Peru, South America the Health Ministry approved

-Hydroxychloroquine 400 mg twice daily the first day, then 200 mg twice daily for 6 days (total 7 days).

– Ivermectin 200 mcg per Kilo of bodyweight. Maximum 10 mg (50 drops).

– Azithromycin 500 mg the first day, then 250 mg for 4 days (total 5 days).

– Chloroquine can substitute hydroxychloroquine if unavailable.

https://cdn.www.gob.pe/uploads/document/file/694719/RM_270-2020-MINSA.PDF

https://www.gob.pe/institucion/minsa/normas-legales/563764-270-2020-minsa

  • Tue, Sep 01, 2020 - 06:47pm

    #6
    cgarcia

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    List of promising COVID-19 treatment protocols worldwide

Bangladesh tried an Ivermectin + Doxycycline combo which proved even superior to Hydroxychloroquine + Azithromycin

http://www.bcpsjournal.org/mhcms-admin/media/pdf/article761.pdf

ivermectin 18 mg on first day and Doxycycline 100 mg twice daily for 05 days
Compared to hydroxichloroquine 800 mg on first day then 400mg daily for 10 days and azithromycin 500 mg one day then 250 g daily for 4 days.

 

200mcg/kg single dose of Ivermectin along with Doxycycline 100mg orally daily for 10 days

http://www.bcpsjournal.org/mhcms-admin/media/pdf/article762.pdf

  • Tue, Sep 01, 2020 - 07:45pm

    #7
    cgarcia

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    List of promising COVID-19 treatment protocols worldwide

This is a news release in the Bolivian Health Ministry website where they authorize Ivermectin use for COVID-19.

Anyone has a link to the treatment protocol and dosages?

https://www.minsalud.gob.bo/4157-ministerio-de-salud-autoriza-uso-de-ivermectina-contra-el-covid-19-bajo-protocolo

https://www.minsalud.gob.bo/component/jdownloads/?task=download.send&id=427&catid=27&m=0&Itemid=646

 

There’s a Bolivian protocol here but it doesn’t mention Ivermectin

https://www.minsalud.gob.bo/component/jdownloads/?task=download.send&id=501&catid=30&m=0&Itemid=646

  • Tue, Sep 01, 2020 - 07:55pm

    #8
    cgarcia

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    List of promising COVID-19 treatment protocols worldwide

A doctor in the Dominican Republic tried 100 to 200 micrograms per kilogram and have progressed that to 400 micrograms per kilogram of bodyweight. Also include it with Azithromycin (dosage, treatment length?).

Interview here:

President of Dominican Republic’s Largest Private Health Group Discusses the Success of Ivermectin as a Treatment for Early Stage COVID-19

  • Tue, Sep 01, 2020 - 07:59pm

    #9
    cgarcia

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    List of promising COVID-19 treatment protocols worldwide

Yale New Haven Health Protocol

HCQ x 5 days

Tocilizumab, methylprednisolone can be added

https://www.rivm.nl/sites/default/files/2020-04/YNHHS%20Treatment%20Algorithm%20for%20Hospitalized%20Adults%20with%20Non–Severe%20COVID-19.pdf

https://www.rivm.nl/documenten/ynhhs-treatment-algorithm-hospitalized-adults-non–severe-COVID-19

  • Wed, Sep 02, 2020 - 12:48pm

    #10
    KathyP

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    List of promising COVID-19 treatment protocols worldwide

Dosages:

Excerpt from Methodology section of  “A Randomized Trial of Ivermectin-Doxycycline and Hydroxychloroquine-Azithromycin therapy on COVID19 patients.”

 

All patients who tested positive for SARS-CoV-2 infection by RT PCR at Chakoria Upazilla Health Complex, Cox’s Bazar; Bangladesh from May 2nd to June 5th, 2020 were initially included in this study, including those with and without symptoms The PCR analysis of the collected sample was done in Cox’s Bazar Medical College. All patients received a full evaluation, including a history of current illness, comorbid condition, and associated complaints. Patients with unstable comorbid conditions like bronchial asthma, COPD, ischemic heart disease, uncontrolled diabetes mellitus, advanced renal and hepatic disease, carcinoma, hospitalized, and Immuno-compromised patients were then excluded. Patients were all examined with a pulse oximeter and only those with normal oxygen saturation of 95% or above were included. Patients with respiratory symptoms received chest radiograph and only those with normal or near-normal chest radiograph were included

Randomization was done using an odd-even methodology applied to registration numbers, in a consecutive fashion in a 1:1 ratio, by the hospital registration office. Treatment was given and final enrolment was done by the attending physician (Investigator). All the patients enrolled in the study were treated as an outpatient.

For the study purpose, the patients were divided into two groups, as follows:

Group A (n = 60): Ivermectin 200µgm/kg single dose + Doxycycline 100 mg BID for 10days

Group B (n = 56): Hydroxychloroquine 400 mg 1st day then200mg BID for 9days + Azithromycin 500 mg daily for 5Days.

Dosing of Ivermectin was determined by the current standard of care depending on some observational study performed in Bangladesh. HCQ dosing was decided as per “National guideline for COVID19 management 4.0”.

All subjects were also provided with symptomatic treatment for fever, headache, cough, myalgia, etc. Drug interactions and contraindications for each individual were considered carefully. The schedule of medication intake was properly explained to each patient. Instructions for Group A included that the Ivermectin tablet (200 µg/kg) single dose was to be taken on an empty stomach one hour before a meal on the first day and that the Doxycycline 100 mg capsule was to be taken twice daily after food for 10 days starting from day one. Instructions for Group B included that the Hydroxychloroquine 400 mg (2tablets of 200 mg each) was to be taken on the first day then 200 mg (one tablet) twice daily after food for 9days, and that the Azithromycin 500 mg (one tablet of 500 mg) was to be taken once daily after food for 5days starting from day one. Patients were advised to self-isolate, and to take proper nutrition, hydration, and to maintain a sanitary environment.

All subjects underwent repeat nasopharyngeal and throat swab PCR for SARS-CoV2 every other day until their PCR was negative. These repeat PCR tests began on the 5th day after taking the medication for subjects who began the study and remained symptom-free. For subjects who began the study with symptoms or developed symptoms, the PCR repeat testing began on the 2nd symptom-free day onward. The investigators had telephone contact with all subjects every 3 days throughout the study, to determine if there were any adverse effects or side effects of the therapy.

Endpoints were a negative PCR and resolution of symptoms. The duration from the first day of drug intake to the negative PCR was counted as the Recovery Period to Negative PCR, and the duration from the first day of drug intake to the disappearance of symptoms was counted as the Period to Symptomatic Recovery. “Adverse Effects” were determined by the existence of the pharmacological side effects of the particular drug during treatment. A detailed history of adverse effects (other than the previous disease symptoms) experienced by each participant was collected during the follow-up sample collection. Informed written consent was obtained in every case. An asymptomatic participant was who presented with no symptom of COVID-19 and remain the same until the negative PCR.

Statistical analysis was done by Graph pad Prism software. Column analysis was done to find the mean with the standard deviation in each group. T-test was done to see the significance between the values where needed.

 

Study link:  https://www.researchsquare.com/article/rs-38896/v1

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