Ivermectin neurotoxicity and MDR1 expression
Some small number of people ( and animals ) with the MDR1 gene expression experience neurotoxicity.
There are many tests *for animals* available to screen for MDR1 gene expression
my question is, how do I get this test for a human.. This MDR1 gene and neurotoxicity needs to be discussed in the Ivermectin context
thx for all the great critical thinking
Redacted, which SNP (e.g. variant) of MDR1 gene expression is of concern? Some of these things can be searched by those who did genetic testing with 23 and me or ancestry. Another issue I heard in a youtube video by Dr. Been that there could be concerns about patients with severe blood brain permeability issues but given the lethality of Covid in some of those people perhaps a single dose is better than nothing I really don’t know. Do you know what type of neurotoxicity has been reported?
Hi sorry I missed this reply, this PP website is incredibly slow and glitchy
here is a reporting of Ivermectin neurotoxic reactions in humans
Ideally yes we could get our genomic data and look for this, although saying it is easier than doing it. The retail genetic testing kits seem mostly about ancestry research.
I have 23 and me and I checked my records for mdr-1 and ABCB1 and could find neither.
I just ordered Ivermectin but the side effects of coma/death are a bit startling, I wonder how small the number is of people who experience this.
But then another paper proclaims:
Ivermectin has continually proved to be astonishingly safe for human use. Indeed, it is such a safe drug, with minimal side effects, that it can be administered by non-medical staff and even illiterate individuals in remote rural communities, provided that they have had some very basic, appropriate training.
I don’t have the scientific background that Chris does, but it looks to be generally safe.
I get the sense that “someone” is starting to react to Ivermectin with some annoyance.
Ivermectin has been given more than a billion times to hundreds of millions of people over more than 30 years. Here is an article, written in 2017 (i.e. before COVID), that provides chapter and verse:
Ivermectin has now been used for over three decades to treat parasitic infections in mammals, and has an extremely good safety profile, with numerous studies reporting low rates of adverse events when given as an oral treatment for parasitic infections. Several problematic reactions have been recorded, but they are generally mild and usually do not necessitate discontinuation of the drug.
Contrast that with the COVID vaccine tech that has never been used in human history, that has been given to tens of thousands for just the past 3 months, which has caused a number of them to feel hurt, sore, get fever, and even some to suffer anaphylactic shock (at least in the UK), and about which no long term data is available.
That’s relative risk for using ivermectin vs “the vaccine” as prophylaxis.
Ivermectin as COVID cure:
Dave, yeah that is pretty crazy isnt it.. No one can be this stupid.. Just, its all about the money. Its fricken obvious.. What is amazing, you cant get through to the stupid “ignorant” people because the powers that be ( who also control the media ) block it all with lies on MSM
let’s bring the thread back on topic. I already have my Ivermectin ( plus doxy etc ) pills right here, want to understand the exact risk ( there is always a risk )
This drug has been used so often and is so well characterized, I can get my dog or horse tested for this gene no problem
my question is, if I visit my doc for blood work, exactly what test do I ask for
Thanks Dave for adding some perspective to this, I think you are right.
As with many drugs, particularly ones with a long half-life, ivermectin may be toxic at therepeutic doses for people with a damaged blood-brain barrier or with a (rare) lowered expression of the P-glycoprotein 1 (P-gp, MDR1), because “P-glycoprotein is an integral component of the human blood brain barrier and plays a central role in limiting drug uptake into the brain. Altered expression or function of p-glycoprotein could conceivably allow elevation of brain concentrations of ivermectin and produce severe neurotoxicity.”
Also worth noting is that the commonly used antiinflammatory drug dexamethasone induces (i.e. increases the expression of) P-gp, and that lowered P-gp expression in the blood-brain barrier means also in the intestines (i.e. lowered absorption when used orally) — both factors reducing the potential for low P-pg induced neurotoxicity. So that’s actually a good reason to use dexamethasone over the equally-or-more common corticosteroids prednisone or methylprednisolone, if you need to use a corticosteroid at all (which shouldn’t be needed if using ivermectin appropriately).
Damaged gut lining and/or BBB (which often go together) can be reduced/improved with an anti-inflammatory diet such as the GAPS diet, especially by eliminating all gluten and other giant weird proteins for 6+ months.