Ivermectin inhibits replication for SARS-CoV-2
The best part is that one dose reduces the viral load by a factor of 5000x AND it’s already an FDA approved drug.
It’s even commonly used and a generic drug.
•Ivermectin is an inhibitor of the COVID-19 causative virus (SARS-CoV-2) in vitro.
•A single treatment able to effect ∼5000-fold reduction in virus at 48h in cell culture.
•Ivermectin is FDA-approved for parasitic infections, and therefore has a potential for repurposing.
•Ivermectin is widely available, due to its inclusion on the WHO model list of essential medicines.”
This is very very interesting. Here’s my potential real life dilemma: I start to develop the usual signs and symptoms of COVID. I call my PCP, hoping to get a prescription for HCQ to start taking as soon as possible. She refuses, saying her hands are tied since she doesn’t have a clear diagnosis based on testing. She recommends that I stay put at home and monitor myself for worsening sx. So I realize I’m on my own. But I have a supply of ivermectin that I use for my pup to prevent heart worm. I’ve also obtained some zinc. Should I start taking the ivermectin although there are no in vivo studies demonstrating efficacy? Since it’s been shown to be safe in humans what do I have to lose? What would others do?
I have wormed myself many times with ivermectin, cydectin, moxydectin,,,and those are the eating also the sols.
my concern is the dose weight in humans with transdermal ivermectin. Bovid and Canid physiology is far from us. When using pour on ivermectin worming and lousing 200 head of cattle, I get a lot on me the sensation was warming and spite reddening of the soaked skin(I was young didn’t use gloves). I did find a dead tick on myself once!
In sheep, the injectable form is far more effective.
I have 1 or 2 liters around. A rural farm store will have it OTC.
I saw that and that is a dosage for a variety of parasites. Is it best injected? It is for goats and sheep. Transdermal? It is for cattle. Would I take it? I dunno.
thanks for the link.
Appreciate the heads up on Ivermectin’s use in COVID-19.
Ivermectin is used in humans globally to treat many roundworm parasites. In the USA, it is used for resistant scabies and head lice.
drugs.com agrees that Ivermectin prevents replication of SARS2-CoV in cell culture and advises that animal testing is underway. It is already FDA approved and accepted as safe for human use.
The dose is 0.2 mg of drug for every Kg of body weight. (0.2 mg/Kg) The typical 70 Kg adult will need 12 mg Ivermectin in a single dose.
Traditionally, the drug is taken on an empty stomach with a full glass of water, but a more recent study shows better absorption if taken with a fatty meal.
Drug is metabolized by the liver, but no dosage adjustment in liver disease recommended.
Ivermectin is a bit “nasty” with some miserable side-effects: headache, nausea, diarrhea, dizziness when standing up, muscle aches. (Unfortunately, these overlap with the symptoms of the viral infection itself creating uncertainty about whether a person is getting sicker or having a medicine side-effects.)
The word must be out. Checked a few vet supply stores online. Most are backordered, and a few have order limit due to the info coming out about it possibly working for covid-19.
Been doctoring a calf this week. So decided to check my supply. My Ivermec(Endo-Mectin) is out of date by a couple years. Will check the feed store tomorrow, to resupply.
I have always used Ivermectin 1% solution. Hopefully no one uses this without talking to a doctor, or vet first. But I’ve had a few people that asked me about dosage. They were trying to convert the 200 mcg per kg of body weight, and ended up with doses that were ten times to much! Remember there is 10 mg’s of Ivermectin per ml/cc of 1% solution.
So 1 ml or cc is enough for 110 lbs of body weight
Human dose is same as for cattle.