Hard Assets Alliance IRA

Ivermectin inhibits replication for SARS-CoV-2

Login or register to post comments Last Post 0 reads   8 posts
  • Tue, Apr 07, 2020 - 12:59am

    #1
    Sorbe1

    Sorbe1

    Status Member (Offline)

    Joined: Apr 07 2020

    Posts: 2

    count placeholder2+

    Ivermectin inhibits replication for SARS-CoV-2

https://www.sciencedirect.com/science/article/pii/S0166354220302011

The best part is that one dose reduces the viral load by a factor of 5000x AND it’s already an FDA approved drug.

It’s even commonly used and a generic drug.

“Highlights
•Ivermectin is an inhibitor of the COVID-19 causative virus (SARS-CoV-2) in vitro.
•A single treatment able to effect ∼5000-fold reduction in virus at 48h in cell culture.
•Ivermectin is FDA-approved for parasitic infections, and therefore has a potential for repurposing.
•Ivermectin is widely available, due to its inclusion on the WHO model list of essential medicines.”

  • Tue, Apr 07, 2020 - 07:11am

    #2
    Credenda

    Credenda

    Status Member (Offline)

    Joined: Mar 19 2020

    Posts: 22

    count placeholder

    Ivermectin inhibits replication for SARS-CoV-2

This is very very interesting. Here’s my potential real life dilemma: I start to develop the usual signs and symptoms of COVID. I call my PCP, hoping to get a prescription for HCQ to start taking as soon as possible. She refuses, saying her hands are tied since she doesn’t have a clear diagnosis based on testing. She recommends that I stay put at home and monitor myself for worsening sx. So I realize I’m on my own. But I have a supply of ivermectin that I use for my pup to prevent heart worm. I’ve also obtained some zinc. Should I start taking the ivermectin although there are no in vivo studies demonstrating efficacy? Since it’s been shown to be safe in humans what do I have to lose? What would others do?

  • Tue, Apr 07, 2020 - 07:35am

    #3
    robie robinson

    robie robinson

    Status Gold Member (Offline)

    Joined: Aug 25 2009

    Posts: 970

    count placeholder

    Ivermectin inhibits replication for SARS-CoV-2

I have wormed myself many times with ivermectin, cydectin, moxydectin,,,and those are the eating also the sols.

my concern is the dose weight in humans with transdermal ivermectin. Bovid and Canid physiology is far from us. When using pour on ivermectin worming and lousing  200 head of cattle, I get a lot on me the sensation was warming and spite reddening of the soaked skin(I was young didn’t use gloves). I did find a dead tick on myself once!

In sheep, the injectable form is far more effective.

I have  1 or 2 liters around. A rural farm store will have it OTC.

  • Tue, Apr 07, 2020 - 08:31am

    #4
    yogmonster

    yogmonster

    Status Member (Offline)

    Joined: Apr 01 2013

    Posts: 47

    count placeholder1+

    Ivermectin inhibits replication for SARS-CoV-2

https://www.drugs.com/dosage/ivermectin.html

  • Tue, Apr 07, 2020 - 08:44am

    #5
    robie robinson

    robie robinson

    Status Gold Member (Offline)

    Joined: Aug 25 2009

    Posts: 970

    count placeholder

    Ivermectin inhibits replication for SARS-CoV-2

I saw that and that is a dosage for a variety of parasites. Is it best injected? It is for goats and sheep. Transdermal? It is for cattle. Would I take it? I dunno.

thanks for the link.

  • Tue, Apr 07, 2020 - 09:03am

    #6

    sand_puppy

    Status Platinum Member (Offline)

    Joined: Apr 13 2011

    Posts: 2296

    count placeholder3+

    Ivermectin inhibits replication for SARS-CoV-2

Appreciate the heads up on Ivermectin’s use in COVID-19.

Ivermectin is used in humans globally to treat many roundworm parasites.  In the USA, it is used for resistant scabies and head lice.

drugs.com agrees that Ivermectin prevents replication of SARS2-CoV in cell culture and advises that animal testing is underway.  It is already FDA approved and accepted as safe for human use.

The dose is 0.2 mg of drug for every Kg of body weight. (0.2 mg/Kg)  The typical 70 Kg adult will need 12 mg Ivermectin in a single dose.

Traditionally, the drug is taken on an empty stomach with a full glass of water, but a more recent study shows better absorption if taken with a fatty meal.

Drug is metabolized by the liver, but no dosage adjustment in liver disease recommended.

—–

Ivermectin is a bit “nasty” with some miserable side-effects:  headache, nausea, diarrhea, dizziness when standing up, muscle aches.  (Unfortunately, these overlap with the symptoms of the viral infection itself creating uncertainty about whether a person is getting sicker or having a medicine side-effects.)

  • Tue, Apr 07, 2020 - 07:42pm

    #7
    yogmonster

    yogmonster

    Status Member (Offline)

    Joined: Apr 01 2013

    Posts: 47

    count placeholder

    Ivermectin inhibits replication for SARS-CoV-2

The word must be out. Checked a few vet supply stores online. Most are backordered, and a few have order limit due to the info coming out about it possibly working for covid-19.

Been doctoring a calf this week. So decided to check my supply.  My Ivermec(Endo-Mectin) is out of date by a couple years.  Will check the feed store tomorrow, to resupply.

  • Tue, Apr 07, 2020 - 08:13pm

    #8
    yogmonster

    yogmonster

    Status Member (Offline)

    Joined: Apr 01 2013

    Posts: 47

    count placeholder

    Reply To: Ivermectin inhibits replication for SARS-CoV-2

I have always used Ivermectin 1% solution.   Hopefully no one uses this without talking to a doctor, or vet first.  But I’ve had a few people that asked me about dosage.  They were trying to convert the 200 mcg per kg of body weight, and ended up with doses that were ten times to much!  Remember there is 10 mg’s of Ivermectin per ml/cc of 1% solution.

So 1 ml or cc is enough for 110 lbs of body weight

Human dose is same as for cattle.

Viewing 8 posts - 1 through 8 (of 8 total)

Login or Register to post comments