“ivermectin could be useful as a broad-spectrum antiviral agent”

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  • Fri, Sep 17, 2021 - 08:27am

    #1
    atom

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    “ivermectin could be useful as a broad-spectrum antiviral agent”

Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290143/

Conclusion:

In this systematic review, we showed antiviral effects of ivermectin on a broad range of RNA and DNA viruses by reviewing all related evidences since 1970. This study presents the possibility that ivermectin could be a useful antiviral agent in several viruses including those with positive-sense single-stranded RNA, in similar fashion. Since significant effectiveness of ivermectin is seen in the early stages of infection in experimental studies, it is proposed that ivermectin administration may be effective in the early stages or prevention. Of course, confirmation of this statement requires human studies and clinical trials.

Ivermectin, owing to its antiviral activity, may play a pivotal role in several essential biological processes, therefore it could serve as a potential candidate in the treatment of different types of viruses including COVID-19. Clinical trials are necessary to appraise the effects of ivermectin on COVID-19 in clinical setting and this warrants additional investigation for probable benefits in humans in the current and future pandemics. On April 10, 2020, FDA issued a statement concerning self-administration of ivermectin against COVID-19 [43] referring to recently published in vitro study on this subject [15]. FDA highlighted that this type of in vitro study is usually used in the early stages of drug development. Moreover, further trials are needed to confirm the safety and efficacy of ivermectin for human use against COVID-19 to discover preventive or therapeutic window [43].

As noted, the activity of ivermectin in cell culture has not reproduced in mouse infection models against many of the viruses and has not been clinically proven either, in spite of ivermectin being available globally. This is likely related to the pharmacokinetics and therapeutic safety window for ivermectin. The blood levels of ivermectin at safe therapeutic doses are in the 20–80 ng/ml range [44], while the activity against SARS-CoV2 in cell culture is in the microgram range. Ivermectin is administered orally or topically. If safe formulations or analogs can be derived that can be administered to achieve therapeutic concentrations, ivermectin could be useful as a broad-spectrum antiviral agent.

 

  • Fri, Sep 17, 2021 - 08:45am

    #2
    Kathy

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    “ivermectin could be useful as a broad-spectrum antiviral agent”

I think this is the issue.  I think if IVM gets out and ends up in everyone’s medicine cabinet half the medical industrial complex becomes unneeded.

Add in vitamin D and weight management and we might be able to go back to the doctor with a medical bag making house calls.

  • Fri, Sep 17, 2021 - 09:11am

    #3
    Kat43

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    “ivermectin could be useful as a broad-spectrum antiviral agent”

The nightmare of the past year+ hasn’t been all bad.  Western medicine has definitely been set back by the need for , and resultant discovery of, basic anti-viral medicines.  Their mantra of, it’s viral so we can’t do anything about it (besides vaccines), is falling apart.

On the other hand, if the rumor is true that the infrastructure bill includes a side provision that would make (many? most? all?) OTC supplements in the US illegal, we’re screwed.  Stock up for now if you can, but they only last for so long.

  • Fri, Sep 17, 2021 - 09:29am

    #4
    DanSte

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    Storage temperature for ivermectin paste

The storage temperatures listed on the boxes of ivermectin paste are surprisingly restrictive.

STORAGE INFORMATION: Store at68°F – 77°F (20°C – 25°C). Excursions between 59°F – 86°F (15°C – 30°C) are permitted.

Most household refrigerators would be too cold.  Storing outside refrigerator risks being too hot.

How are people handling this?

How damaging is it to exceed these ranges?

  • Fri, Sep 17, 2021 - 09:44am

    #5
    US Strength

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    COVID CORRUPTION HAS BEEN THE BIGGEST “OWN GOAL” BY BIG PHARMA

They have woken us up to their broad-spectrum corruption and accountability will come!

  • Fri, Sep 17, 2021 - 09:58am

    #6

    sand_puppy

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    Ivermectin sold out

Ivermectin is sold out at Chewy.com, ValleyVet.com.  I called ValleyVet and they had no suggestions as to anyone still having stock.  Manufacturers cannot keep up with supply.

A friend of a friend went to multiple feed stores in Southern CA and found that they would only sell a few tubes per person and required a note from a vet prior to making the sale.

She came away empty handed despite having COVID and having a spouse with morbidities similarly infected.  (We are using the rest of the FLCCC Alliance stuff, though)

  • Fri, Sep 17, 2021 - 10:07am   (Reply to #4)

    #7
    RandomMike

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    Storage in freezer

The colder the better to stop deterioration. Frozen is best IMHO.  After defrosting the gel it appears the same as it was before freezing.

  • Fri, Sep 17, 2021 - 10:35am   (Reply to #6)

    #8
    DreamsAwake

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    “ivermectin could be useful as a broad-spectrum antiviral agent”

Sand-Puppy “Ivermectin Sold Out”

I just went on Amazon and horse paste is still available here., (although now MUCH more expensive.)

I purchased some here a few months back,($16 tube) and the e shipping time sounded like it was going to take a while, but it arrive in a couple of days.

Good luck!

  • Fri, Sep 17, 2021 - 11:02am   (Reply to #4)

    #9
    acesovereggs

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    “ivermectin could be useful as a broad-spectrum antiviral agent”

6th post from the bottom, albeit about an injectable version:

http://gundogforum.com/forum/viewtopic.php?t=6359

 

“Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.”, from below, talking about I think the pill version:

https://www.drugs.com/cons/ivermectin.html

 

Going back to the ivomec injectable,

“Stability
IVOMEC Injection has been shown to be stable for five years when stored under normal conditions.

Storage
Store bottle in carton to protect from light.”, from:

https://www.drugs.com/vet/ivomec-injection-for-cattle-sheep-and-swine-can.html

You can find other opinions in favor of refrigeration/freezing, but not sure that’s best or makes a difference in this situation, imho.

 

 

  • Fri, Sep 17, 2021 - 11:09am   (Reply to #3)

    #10

    dgbd

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    “ivermectin could be useful as a broad-spectrum antiviral agent”

Hi Kat43, I think if most OTC supplements became illegal to buy that would inspire a massive black market. They would be creating an incentive similar to prohibition in the 20’s. Just think heroin, meth, and vitamin D from your corner dealer.

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