HCQ RCT Results Pending

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  • Tue, May 26, 2020 - 12:24am

    #1

    davefairtex

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    HCQ RCT Results Pending

There is a PET/PEP HCQ study that was started at University of Minnesota.   This study includes both early treatment, as well as HCQ as prophylaxis both for contacts as well as for healthcare workers.  (There appear to be several different arms of the study; I was a bit confused).

It is all done on an outpatient basis – all via mail.

The “early treatment” study was scheduled to finish May 14th.  No results yet.  Unlike in the Remdesivir trial, the investigators are not going to release results without going through peer review.  There were problems getting enough people into the trial.  Too many trials going on, and a whole lot of “scary news” about HCQ.

And no – no zinc.  But given that people do really get zinc from their diet, and most Americans (86%) don’t have an actual zinc deficiency, it should work better than placebo.  And hopefully the study will have enough participants to provide enough statistical power to come up with an answer.

The site to enroll in the PREP arm which is still going on – you have to be a high risk healthcare worker:

https://covidprep.umn.edu/

And the site for their research overall:

https://www.covid-19research.ca/home

The trial:

https://clinicaltrials.gov/ct2/show/NCT04308668

Here is the twitter feed of the lead investigator on the trial, David Boulware.  His feed was really interesting.  Go back to March 23rd, and go forward from there.

https://twitter.com/boulware_dr

And an article about him in the campus rag:

https://med.umn.edu/news-events/dr-david-boulware-works-find-answers-neglected-new-diseases

Some selected tweets from Dr Boulware – highlights mine:

We placed facebook ads over the weekend in high #COVIDー19 incidence areas for our clinical trial. My impression: 1/2 of people, think it’s unethical to do a trial because HCQ works. The other 1/2 of people, think it’s unethical to do a trial because HCQ alone is dangerous.

#Hydroxycloroquine Pre-Exposure Prophylaxis (PrEP) trial launched on April 6. ~1500 health care workers from around the USA have volunteered to test 1x or 2x weekly HCQ. Total budget for the trial was $198,000, submitted on April 7 to @NIH. Have heard only crickets.

Our #COVID19 randomized prevention trial has enrolled 0 subjects since FDA sent out a caution on Friday. Our dose used is 4-fold lower than used in Brazil JAMA study and without azithromycin. We are going to 1) implement remote EKG monitoring (IRB pending); 2) Add serology.

Our #hydroxychloroquine randomized, placebo-controlled clinical trials completed on May 6. Two trials tested post-exposure prophylaxis & early treatment for #COVIDー19 Analysis, results, & manuscripts are in process, & following scientific peer review, we will release our results

We continue to enroll for our COVID19 prevention and preemptive early treatment trials. http://covidpep.umn.edu In reviewing the safety data to date of 1290 participants randomized, we have had no serious adverse events due to #hydroxychloriquine.

Takeaways:

1) The FDA’s “caution” crushed enrollment in Boulware’s RCT.

2) nobody died from taking that scary medicine [“no serious adverse effects”], and

3) results should be coming any day now, and

4) Dr Fauci, for all his fancy talk about science and his $41 billion dollar budget, he is apparently uninterested in funding actual HCQ RCTs.

Maybe the medicine is too cheap, or the study finishes too early for him to be truly happy. In any event, people hoping for “science” from Fauci … may well be disappointed if it doesn’t involve a really expensive medicine (useful only to people who are hospitalized) from a company he happens to like.

Dr Boulware points at least some of this out, but you have to read between the lines to hear him say it.

He might be an interesting interview for Chris.  Should he choose to put his career at risk, of course.

  • Tue, May 26, 2020 - 09:34pm

    #2
    PdeB

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    HCQ RCT Results Pending

Good find, Dave. Thanks for sharing. Do you know a source of compiled anecdotal evidence that HCQ works (when used properly)?

 

I’m thinking about searching through all of Chris’s videos but imagining there’s an easier way 🙂

  • Wed, May 27, 2020 - 02:18am

    #3

    davefairtex

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    HCQ RCT Results Pending

I do not have all the HCQ studies amassed in one place.  Doing such a thing would be an excellent idea.

The concept of an “anecdote” is amusing to me in this context.  One man’s anecdote is another man’s 3000-patient treatment-outcome summary.

If Raoult can get 3 days of treatment into his patients, mostly, they live (18 deaths for 3300 patients).  Contrast with 157 deaths for 4885 patients at another hospital.  Is that an anecdote?  To Fauci, presumably, it is.

https://www.mediterranee-infection.com/covid-19/

Fauci, being a fantastic scientist, wants an RCT.  He refuses to accept 3000-patient “anecdotes”, he’s just that rigorous.

Well, he claims to want an RCT – right up until an investigator asks NIH for funding for an actual HCQ RCT.  Then – as the investigator himself said – it is “crickets” from Fauci.  I used to respect the man.  Until I saw what he actually did.

It took me about 5 hours to put today’s forum post together – sort through all the pending trials, find one that is close (or was supposedly finished), then pore over all the tweets, sort out the ones that mattered.  Perhaps someone else can construct the list of HCQ studies that showed us efficacy.

Crickets.  I’ll never forget that tweet.

  • Wed, May 27, 2020 - 04:45am

    #4
    dragonfishy

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    HCQ RCT Results Pending

SARS Cov2 uses same mechanism as HIV to evade the immune system, down regulates MHC antigens … Makes a vaccine less likely, the research also mentions chloroquine increasing MHC expression making it easier for the immune system to find infected cells: article link:

https://www.biorxiv.org/content/10.1101/2020.05.24.111823v1

  • Wed, May 27, 2020 - 11:36pm

    #5
    PdeB

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    HCQ RCT Results Pending

Appreciate your contributions Dave. I’ll see if I can make some headway on compiling HCQ evidence this weekend.

  • Thu, May 28, 2020 - 06:58pm

    #6
    Curtclipper

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    HCQ RCT Results Pending

Hi everybody

My Doctor said no to my request for hcq and zpac. I asked the nurse what they use and she told me “well lots Of water” . I’m not sick but I’m going on a 6 weeks surf trip thru Costa Rica and Mexico. My only fear is of course the air travel. I wanted either a prophylactic or just to carry the dose I with my first aid in case I did get sick. Of course I’ll use a mask and eyewear on the plane but I like to cover all the bases. I’m quitting this hospital and will be looking at another doc and hospital. But I don’t know how to ask for this request or who to ask to find a doctor who does use it. Any reply is greatly appreciated. Thanks

  • Thu, May 28, 2020 - 08:15pm

    #7

    Jim H

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    Didier Raoult Gold – interview with English subtitles

A new interview with English subtitles – it’s worth it to watch just to see Raoult laugh at the absurdity of the Lancet study when he is discussing it.  He pretty much says, “should I believe my own eyes, or not?”.  You gotta love this guy.

Importantly, and in showing what a consummate real scientist he is, Raoult is suggesting now that Zinc is important and that they missed it early on.. he says, “We know that there were many things that were underestimated, for example people with low Zinc levels were more affected”.  BAM!  The picture keeps getting more clear – the HCQ regimen needs Zinc for best chances of success.

Well worth a watch;

  • Thu, May 28, 2020 - 09:01pm

    #8

    Jim H

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    Costa Rica & Malaria

You have to ask the right way.  You want Malaria prophylaxis before travelling to Costa Rica;

https://www.cdc.gov/malaria/new_info/2018/Costa_Rica_5_2018.html

CDC recommends that travelers to the Osa Peninsula in Costa Rica take medications to prevent malaria. Effective antimalarial options include atovaquone-proguanil, chloroquine, doxycycline, and mefloquine.

  • Sat, May 30, 2020 - 08:49am

    #9

    davefairtex

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    HCQ RCT Results Pending

From the good doctor’s twitter feed:

Andrew Bostom @andrewbostom May 25 Replying [email protected]_dr

David, when do you expect publication of the results, as what you described—despite your own valuable effort/time (7hrs)–& admitted are in the end “all minor” revisions. esp. given “rapid peer review” & importance of findings?

David Boulware, MD [email protected]_dr May 25 @andrewbostom
hard to know. I would expect this week, although I thought that a week ago.

————–

Well, this week has come, and gone.  Still no word from that unnamed Journal about publishing Dr. Boulware’s HCQ RCT trial results.

Perhaps the unnamed slow-acting Journal is The Lancet.  Maybe they only publish junk science articles from no-name companies that follow a popular narrative that Big Pharma is eager to support, and real results from actual RCTs done properly that threaten this narrative are placed at the back of the … queue, as it were.

 

  • Sat, May 30, 2020 - 09:24am

    #10
    DaveDD

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    Reply To: HCQ RCT Results Pending

Oh boy, that was funny😂

I promised myself to ignore all posts about “research” in general, and the Lancet specifically, but boy you made me laugh.

Take care!

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