COVID-19 & Chronic Fatigue: Connection with Cellular Mitochondrial Dysfunction..

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  • Sat, Jul 04, 2020 - 10:20pm

    #1
    JoeVickers

    JoeVickers

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    COVID-19 & Chronic Fatigue: Connection with Cellular Mitochondrial Dysfunction..

@cmartenson

TITLE:

Proteins Nsp12 and 13 of SARS-CoV-2 Have Mitochondrial Recognition Signal: A Connection with Cellular Mitochondrial Dysfunction and Disease Manifestation

LINK: https://www.preprints.org/manuscript/202006.0352/v1

PDF: https://www.preprints.org/manuscript/202006.0352/v1/download

Abstract:

Proteins Nsp12 and 13 of SARS-CoV-2 Have Mitochondrial Recognition Signal: A Connection with Cellular Mitochondrial Dysfunction and Disease Manifestation
Upasana Ray * and  Feroza Begum

Version 1 : Received: 28 June 2020 / Approved: 29 June 2020 / Online: 29 June 2020 (10:40:07 CEST)

How to cite: Ray, U.; Begum, F. Proteins Nsp12 and 13 of SARS-CoV-2 Have Mitochondrial Recognition Signal: A Connection with Cellular Mitochondrial Dysfunction and Disease Manifestation. Preprints 2020, 2020060352 (doi: 10.20944/preprints202006.0352.v1). Ray, U.; Begum, F. Proteins Nsp12 and 13 of SARS-CoV-2 Have Mitochondrial Recognition Signal: A Connection with Cellular Mitochondrial Dysfunction and Disease Manifestation. Preprints 2020, 2020060352 (doi: 10.20944/preprints202006.0352.v1).Copy
Abstract
Mitochondria are classically termed as powerhouse of a mammalian cell. Most of the cellular chemical energy in the form of adenosine tri phosphate (ATP) is generated by mitochondria and dysregulation of mitochondrial functions thus can be potentially fatal of cellular homeostasis and health. Acute respiratory distress has been earlier linked to mitochondrial dysfunction. SARS-CoV-2 infection severity leads to acute respiratory distress syndrome (ARDS) and can be fatal. We tried to investigate possible connection between SARS-CoV-2, ARDS and mitochondria. Here, we report identification of SARS-CoV-2 non-structural proteins (particularly Nsp12 and 13) that have recognition sequence with respect to mitochondrial entry. We also report that these proteins can potentially shuttle between cytoplasm and mitochondria based on the localization signals and help in downstream maintenance of the virus. Their properties to use ATP for enzymatic activities may cause ATP scavenging allowing viral RNA functions in lieu of host cell health.
Subject Areas
SARS-CoV-2; ARDS; non-structural proteins; mitochondria
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

  • Mon, Jul 06, 2020 - 10:01am

    #2
    tbp

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    COVID-19 & Chronic Fatigue: Connection with Cellular Mitochondrial Dysfunction..

Don’t underestimate XMRVs, they might be involved in both Covid and CFS.

  • Mon, Jul 06, 2020 - 11:42am

    #3
    JoeVickers

    JoeVickers

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    COVID-19 & Chronic Fatigue: Connection with Cellular Mitochondrial Dysfunction..

@tbp I think we should leave so called XMRV’s out of this forum. The discovery is largely considered fraudulent by the scientific establishment, as they claim they cannot reproduce that one scientist’s results. Though I don’t be an authority on the subject, and so-called consensus matters little as we have seen with HCQ & origins of the honey badger.

Don’t underestimate XMRVs, they might be involved in both Covid and CFS.

And while I do definitely feel the scientist who “discovered” XMRVs was unfairly persecuted (and prosecuted), I am firmly on the side of the argument that the evidence for XMRV’s is extremely lacking – and as of yet no other scientists have been able to replicate the XMRV results (again, I don’t deny that this may been the intetniosn of XMRV critics, but still it is lacking).This is why I don’t what bring up the subject. I am not a biochemist,  so I can’t say they are bunk – but lets not bring up a subject that currently we cannot rely on as being proven real – though I don’t deny XMRVs could be real – its something that the conversation here would be counterproductive.

Back to the subject, does anyone have background in cellular biology to help understand this new data on Mitochondrial dysfunction?

  • Tue, Jul 07, 2020 - 06:22am

    #4
    tbp

    tbp

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    COVID-19 & Chronic Fatigue: Connection with Cellular Mitochondrial Dysfunction..

So you agree that the global and many national “health authorities” are suppressing the actual cures… but when they claim that a scientist exposing their crimes, at great harm to herself and no conceivable benefit, and her career is destroyed like those of so many others (if they didn’t end up dead as a large number of honest scientists have), and she’s censored even more than information about the cures… then we should stick to the “consensus” of the scientific establishment because they consider it “fraudulent”? Isn’t the very fact of how she was treated, strong evidence of wrongdoing? They are the type of people willing to go to your house, drag you out and threaten to kill your family if you don’t drop your scientific research.

The same people suppressing the cures, who funded gain-of-function research, and who maim children by injecting them with aluminum (etc etc etc) even before they have developed a blood-brain barrier to protect them from such a toxic assault, should be believed because you don’t have strong enough confirmation by scientific studies of a type over which they have control? Now THAT’s nuts.

It’s obvious that something MAJOR is involved in CFS, such as vaccine adjuvants damage (aluminum injection), XMRVs, heavy metals from chemtrails or seafood, fluoride, glyphosate, GMOs, high EMF exposure, high-sugar/high-carb/junk-food diet… These are all sources of dysfunction to different degrees, including mitochondrial dysfunction. I’m not saying Honeybadger doesn’t have by itself an ability to affect mitochondria or anything like that; I was just adding a piece of information / research thread.

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