Australian Hydroxychloroquine study: COVID-SHIELD
Thought this might be of interest due to HCQ being maligned due to TDS
If I understand the role of zinc and of the stage of the infection when treatment begins, then this study is set up to fail. I just set them an email, worded thus:
I am no medical specialist, so please excuse my naivety. I have read very good reports of Dr Zelenko’s regimen. I don’t see any mention in your announcement of zinc. Isn’t this study ignoring the essential element, pardon the pun?
Let’s see what response, if any, I get!
I looked up your AU trial. No information on dosing. They are keeping it secret…I’m not quite sure why. Their explanation didn’t make any sense. “To protect patients” or something. It is nice to see that someone experienced in using HCQ is involved in this AU study.
There’s a similar PREP trial running the US, called HERO HCQ.
HERO-HCQ will finish in “July 2020”. HERO-HCQ is a 30-day trial; supposedly it will have 15,000 participants.
Dose is 400 mg 1/day for 30 days; this is is 7x the dose given in India; they give 400 mg once/week for their HCQ PREP program, and they’ve had an 80% success rate.
I’d expect more side effects in HERO-HCQ.
Oh goody more studies designed to fail. And following the same pattern of large doses and no zinc. The media is chomping at the bit to get a hold of this one
The Walter & Eliza Hall Institute is very well respected in Australia, and who knows where else. I do hope they’ve not been manoeuvred into a position by, er, “external forces.”
This commentary points out some of the problems with the study and reasons why it looks designed to find no benefit;
…..This “poor design” is so obvious in the Australian trial that it is simply astonishing that it was approved, if the intent was to test HCQ’s efficacy as stated:
“COVID SHIELD is gold standard in its design as a multi-centre, randomised, double-blind study,” said Professor Pellegrini (of the Walter and Eliza Hall Institute).
This may be true, as the trial will be on 2000 volunteer health care workers, half of whom will take Hydroxychloroquine and half a placebo – without knowing which, and for four months, the object being to see if the drug has a protective effect against SARS-CoV-2 infection.
But because there are only a few cases of active CV19 infection in hospital, and few more likely, most of the volunteers are unlikely to be exposed to the virus. Not only that – because the trial is double blind, all volunteers will be obliged to behave as if they have no protection and so must wear standard protective equipment for the four month period.
At the end of the “trial”, when half of these volunteers will have taken “the possibly dangerous” HCQ every day for four months for no reason, the Institute will be able to declare that there was no difference between HCQ and a placebo, though the result will not be statistically significant because of the low number of infections. (zero presumably) Then like the Emperor’s new clothes, the “results” will be paraded around as the last word on this controversial drug.
Another death – a parent of a friend just died after having been treated with a ventilator, Remdesivir, Convalescent Plasma, and Dexamethasone.
This mistreatment is so frustrating!
It’s one thing to hear numbers, and it’s another when loved ones are dying.
What can be done to turn this ship around? Our country probably has years ahead of us with this virus, and it sure would be nice if we would actually use science.
I guess I will say no more for now except that I am glad to have the information from Chris’s videos and would like them to have more impact. And even they are suppressed.
Suggestions anyone? Great job ezlxq1949 on commenting on the study design. Yet it seems like the system is rotten.
The system does seem to be rotten. All we can do is prepare ourselves with supplements, exercise, and a positive attitude. Fear kills. You do get a vote in how this turns out. Your immune system works best when you are in a state of peace. And – mostly, people survive.
And – we won’t have to wait years. My guess is, we’re about 5-6 weeks away from herd immunity in some of the regions. Wherever we see major spikes in cases [Arizona, Florida, Texas] I would expect that to last only a few more weeks, after which cases will start to taper off, and fall down to fairly low levels – just like what we see now in New York City.
Crazy goings-on in NYC, and no spike in cases. That tells me: herd immunity comes at around 25% infected. Once the socially overactive youngsters get it, and get over it, the pandemic will be largely over in that region.
Thank you Dave! I hope you are right about herd immunity.