Any populations with natural genetic resistance to Covid-19?

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  • Tue, Feb 25, 2020 - 07:21pm

    #1
    quahogs

    quahogs

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    Any populations with natural genetic resistance to Covid-19?

Some ethnic groups have an immunity to certain pathogens.  The CCR5 delta32 mutation offers resistance to Bubonic plague and HIV.

This DNA testing site for CCR5 Delta 32 is advertising also  for Covid-19    https://www.delta-32.com/

Doubtful there’s any empirical data yet to back up this claim.

Here’s map that shows prevalence of the mutation in populations by country

https://www.sciencedirect.com/science/article/pii/S0198885917305104#f0020

East Asian countries and Iran have a low percentage of the population with the mutation.

It will be interesting to see if there ends up being correlation as this virus spread.

Are there any sources of data on the ethnic background of the deaths in Western nations?

How many of deceased in Western countries are of East Asian descent?

 

 

  • Wed, Feb 26, 2020 - 07:53am

    #2
    greendoc

    greendoc

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    Reply To: Any populations with natural genetic resistance to Covid-19?

Thank you Quahogs for finding this super interesting developement.

 

This  appears to be a theory at this time (although based on what appears to be compelling evidence, but I am not a virologist so not qualified to judge the methods or conclusions) .

“In conclusion it is our opinion that individuals with two copies of CCR5-Delta32 mutation could possibly have immunity to the Coronavirus (COVID-19) and individuals with one copy of the CCR5-Delta32 mutation could have a maximum chance of recovery at a event of being infected with the COVID-19 but more research is necessary to be certain.”

https://www.delta-32.com/connections-between-covid-19-and-hiv.html

Fewer than 1% of Caucasians are homozygous and therefore potentially immune.  Individuals who are homozygous have have two copies for the deletion CCR5DD. There are Northern European populations with higher percentages of folks with one copy (heterozygous) of the CCR5-Delta32 deletion: Norway, Britain, Ireland (the color coded map here https://www.sciencedirect.com/science/article/pii/S0198885917305104#b0070)/ Theoretically, these individuals may have increased recovery if infected, but this is simply an untested theory at this time.

This is a brief explanation of CCR5-Delta32 deletion. One of its rsid# is rs333

https://www.snpedia.com/index.php/Rs333

IF you have done a 23andme test in the past you can see what you are by looking up your results online inserting i3003626 into search box here:  https://you.23andme.com/tools/data/.  Or you can do a control find and search for i3003626 in your raw data file from 23andme.  You can learn more here: https://customercare.23andme.com/hc/en-us/articles/212196868-Accessing-Your-Raw-Genetic-Data.  I do not know if Ancestry tests for this, I suspect they do.

You are homozygous if you see -/-. I am not….I am homozygous for insertions (As are the majority of people worldwide!) Darn, I am irish german polish czech, so a chance I could have been heterozygous, but no such luck.

The defective receptor variant CCR5-Δ32 does not always grant immunological advantage. In numerous inflammatory diseases and during infection with some pathogens, CCR5-Δ32 plays a detrimental role instead [14]. A prominent example is infection with West Nile virus, where CCR5-Δ32 homozygosity is associated with a significantly higher risk for fatal outcome [15].

LSS: This homozygous mutation pretty rare, but some Northern Europeans who carry one copy might have a slight edge.  But just a theory. here is the dbSNP and 1000genomes page for this deletion to look at population frequencies.

https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?do_not_redirect&rs=rs333.  You must click on the See additional pop frequency from 1000Genome [here] hyperlink and look at the highlighted column for 1000genome data. In the below screenshot you can some allele frequencies too…the pink bars are people with one copy.  Two copies so rare, does not show up at all.

  • Wed, Feb 26, 2020 - 07:57am

    #3
    greendoc

    greendoc

    Status Bronze Member (Offline)

    Joined: Sep 23 2008

    Posts: 163

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    Any populations with natural genetic resistance to Covid-19?

Thank you Quahogs for finding this super interesting development.

This  appears to be a theory at this time (although based on what appears to be compelling evidence, but I am not a virologist so not qualified to judge the methods or conclusions) .

“In conclusion it is our opinion that individuals with two copies of CCR5-Delta32 mutation could possibly have immunity to the Coronavirus (COVID-19) and individuals with one copy of the CCR5-Delta32 mutation could have a maximum chance of recovery at a event of being infected with the COVID-19 but more research is necessary to be certain.”

https://www.delta-32.com/connections-between-covid-19-and-hiv.html

Fewer than 1% of Caucasians are homozygous and therefore potentially immune.  Individuals who are homozygous have have two copies for the deletion CCR5DD. There are Northern European populations with higher percentages of folks with one copy (heterozygous) of the CCR5-Delta32 deletion: Norway, Britain, Ireland (the color coded map here https://www.sciencedirect.com/science/article/pii/S0198885917305104#b0070)/ Theoretically, these individuals may have increased recovery if infected, but this is simply an untested theory at this time.

This is a brief explanation of CCR5-Delta32 deletion. One of its rsid# is rs333

https://www.snpedia.com/index.php/Rs333

IF you have done a 23andme test in the past you can see what you are by looking up your results online inserting i3003626 into search box here:  https://you.23andme.com/tools/data/.  Or you can do a control find and search for i3003626 in your raw data file from 23andme.  You can learn more here: https://customercare.23andme.com/hc/en-us/articles/212196868-Accessing-Your-Raw-Genetic-Data.  I do not know if Ancestry tests for this, I suspect they do.

You are homozygous if you see -/-. I am not….I am homozygous for insertions (As are the majority of people worldwide!) Darn, I am irish german polish czech, so a chance I could have been heterozygous, but no such luck.

The defective receptor variant CCR5-Δ32 does not always grant immunological advantage. In numerous inflammatory diseases and during infection with some pathogens, CCR5-Δ32 plays a detrimental role instead [14]. A prominent example is infection with West Nile virus, where CCR5-Δ32 homozygosity is associated with a significantly higher risk for fatal outcome [15].

LSS: This homozygous mutation pretty rare, but some Northern Europeans who carry one copy might have a slight edge.  But just a theory. here is the dbSNP and 1000genomes page for this deletion to look at population frequencies.

https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?do_not_redirect&rs=rs333.  You must click on the See additional pop frequency from 1000Genome [here] hyperlink and look at the highlighted column for 1000genome data. In the below screenshot you can some allele frequencies too…the pink bars are people with one copy.  Two copies so rare, does not show up at all.

Claire

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