A new (licorice) twist on SARS replication prevention
Well, search for this paper:
Glycyrrhizin, an active component of liquorice roots, and replication of
I will leave it to younger/smarter people to analyze the article but it seems to me that if the ‘enveloping’ characteristics of iota-carrageenan are what helps it deter the virus, licorice, with its coating protective properties, might work in a similar way.
Licorice has been used for viruses for centuries or perhaps longer. It is well found to have anti-viral properties and has been used for herpes and other viruses.. Its in my arsenal. It doesnt ever expire either.
Published 2003, so study uses SARS Classic. I’d love to see the study repeated with SARS2 – just to be sure. I’m reading this was used on infected cells, so this could be used when it’s too late for HCQ (for instance) ? Is that right?
Chris needs to see this, I think.
This paper from late April also called for its study against COVID-19, stating that its pharmacological action includes “binding angiotensin-converting enzyme II (ACE2), downregulating proinflammatory cytokines, inhibiting the accumulation of intracellular reactive oxygen species (ROS), inhibiting thrombin, inhibiting the hyperproduction of airway exudates, and inducing endogenous interferon”.
And this study from 24th June says this:
Safe and efficient drugs to combat the current COVID-19 pandemic are urgently needed. In this context, we have analyzed the anti-coronavirus potential of the natural product glycyrrhizic acid (GLR), a drug used to treat liver diseases (including viral hepatitis) and specific cutaneous inflammation (such as atopic dermatitis) in some countries. The properties of GLR and its primary active metabolite glycyrrhetinic acid are presented and discussed. GLR has shown activities against different viruses, including SARS-associated Human and animal coronaviruses. GLR is a non-hemolytic saponin and a potent immuno-active anti-inflammatory agent which displays both cytoplasmic and membrane effects. At the membrane level, GLR induces cholesterol-dependent disorganization of lipid rafts which are important for the entry of coronavirus into cells. At the intracellular and circulating levels, GLR can trap the high mobility group box 1 protein and thus blocks the alarmin functions of HMGB1. We used molecular docking to characterize further and discuss both the cholesterol- and HMG box-binding functions of GLR. The membrane and cytoplasmic effects of GLR, coupled with its long-established medical use as a relatively safe drug, make GLR a good candidate to be tested against the SARS-CoV-2 coronavirus, alone and in combination with other drugs. The rational supporting combinations with (hydroxy)chloroquine and tenofovir (two drugs active against SARS-CoV-2) is also discussed. Based on this analysis, we conclude that GLR should be further considered and rapidly evaluated for the treatment of patients with COVID-19.
Licorice root is also part of the protocol for Covid that Stephen Harrod Buhner put together back in January. I have a whole bunch of licorice root tincture in a cabinet that I made back then.