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Daily Digest 8/1 - Probiotic Intervention Affects Mood, We Are All Confident Idiots

Saturday, August 1, 2015, 10:40 AM

Economy

We Are All Confident Idiots (jdargis)

The American author and aphorist William Feather once wrote that being educated means “being able to differentiate between what you know and what you don’t.” As it turns out, this simple ideal is extremely hard to achieve. Although what we know is often perceptible to us, even the broad outlines of what we don’t know are all too often completely invisible. To a great degree, we fail to recognize the frequency and scope of our ignorance.

Mt. Gox head arrested over loss of 650,000 bitcoins (jdargis)

The Tokyo-based Mt. Gox, once the world's largest Bitcoin exchange, shut down in February 2014 after weeks of sustained DDoS attacks and 'transaction malleability' problems, which led the company to halt withdrawals entirely. The exchange applied for bankruptcy protection in Japan, saying it could not pay its debt of $63.6 million (£40 million).

Company Copes With Backlash Against the Raise That Roared (jdargis)

Three months ago, Mr. Price, 31, announced he was setting a new minimum salary of $70,000 at his Seattle credit card processing firm, Gravity Payments, and slashing his own million-dollar pay package to do it. He wasn’t thinking about the current political clamor over low wages or the growing gap between rich and poor, he said. He was just thinking of the 120 people who worked for him and, let’s be honest, a bit of free publicity. The idea struck him when a friend shared her worries about paying both her rent and student loans on a $40,000 salary. He realized a lot of his own employees earned that or less.

A Brief History of Basic Income Ideas (Robely G.)

The idea of an unconditional basic income has three historical roots. The idea of a minimum income first appeared at the beginning of the 16th century. The idea of an unconditional one-off grant first appeared at the end of the 18th century. And the two were combined for the first time to form the idea of an unconditional basic income near the middle of the 19th century.

St. Louis County Biased Against Black Juveniles, Justice Department Finds (jdargis)

The Supreme Court ruled in 1963 that states must provide lawyers to criminal defendants who cannot afford them, and ruled in 1967 that juvenile defendants have the same rights as adults, including the right to counsel and the right against self-incrimination.

Ms. Gupta said department lawyers met Thursday with county and state officials to share the report’s findings, and she hoped to reach an agreement on changes. If that fails, she said, “we certainly have the ability to litigate.”

Accused ISIL sympathizer worked at KW airport (Michael W.)

He described Suarez, who lived with his family in a Stock Island apartment complex on Shrimp Road, as shy and quiet. The two talked motorcycles; Suarez had two Yamahas. Kongos said Suarez worked on upgrading everything from air filters to wiring lights.

"He only had a few other friends and rarely, if ever, posted in Facebook," Kongos said. "To me, he seemed like an average guy. He worked a lot and had decent hobbies like motorcycles, mopeds, even a boat at one time."

The Dream Undone (jdargis)

The fundamental promise of American democracy is that every citizen gets a vote, but delivering the franchise from on high and in the face of violent local opposition has always been a complicated legal proposition. The 13th Amendment freed the slaves, and the 14th Amendment gave them citizenship. But the key to Reconstruction was the 15th Amendment, ratified in 1870, which did something far more radical, not just guaranteeing (male) former slaves the right to vote but giving Congress the authority to enforce that right state by state, an authority that to this day many legislators see as a drastic intrusion into local affairs.

Probiotic Intervention Affects Mood (Arthur Robey)

The exact mechanisms that relate improvement in mood to the consumption of probiotics were not specifically presented in this data, but what we do know is that the gut bacteria regulate several factors that do influence our state of mind. First, the microbiota living within the intestines play a large role in creating the various neurotransmitters that have a significant effect on mood, and these include chemicals like serotonin and dopamine. Second, the gut bacteria regulate the level of inflammation throughout the body and including the brain. The chemical messengers of this process, cytokines, are known to be significantly involved in mood and how we perceive the world around us.

Gold & Silver

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25 Comments

saxplayer00o1's picture
saxplayer00o1
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Puerto Rico Default

Using Google search links for updates:

  1. Puerto Rico
  2. Chicago debt/deficit
  3. Fukushima Prosecutions
cmartenson's picture
cmartenson
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Gut bacteria..

...do they also regulate dimethyltryptamine (DMT) production?  

Just wondering...

If so, then they regulate perception of reality and perhaps we should be slightly more deferential towards our bacterial overlords than we are...

:)

I pose this with curious seriousness, because DMT is an indole alkaloid derived from the shikimate pathway...and DMT has an extraordinarily powerful influence on what we perceive to be 'reality.'

If you've been following this site closely then you know that the shikimate pathway is the one that is disrupted by Glyphosate, or Roundup(tm), the ultra-common herbicide.

To connect all the dots, if you disrupt the shikimate pathway you potentially disrupt how "reality" is experienced...and given that "reality" is such a delicately subjective experience, then even slight tamperings with the machinery of perception can have outsized impacts.

For example, we wonder how these crazed individuals, be they movie theater shooters or seemingly power crazed policemen, can do what they do.  Well, perhaps they are not seeing things (even remotely) the same way that you do in no small measure because their gut biome is sending them signaling molecules that provide them with entirely different perceptions of 'reality'?

...just a thought...but one of the main narratives we might need to challenge is the one that states that 'reality' is an objective experience...perhaps it (very much) is not?

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westcoastjan
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Chris if what you hypothesize is true...

...then we are even more screwed than we think.

Your thoughts tie in to a degree with my thinking in the school shooting essay I wrote which was featured here on this site way back when. My rationalization in that essay was defective genetics was a contributing factor to the inexplicable violence. I have no doubt at all that what we consume plus genetic diversity combine to create, for lack of a better word, defective individuals. It is a numbers game as far as I can understand - X number of the population are going to be defective in some manner. The defects may show up in myriad ways, from health issues to increases in the crazies who commit the violence that is, to most of us, seemingly irrational and inexplicable.

Scary thoughts, but at the same time, makes sense at least to me. There are some things we can control via what we consume (or not consume). Since humans seem quite eager to jump on the latest fad, whether probiotics or something else, it does pay to do serious due diligence before jumping on the latest bandwagon.

Jan

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Defective individuals

Westcoastjan,

That tallies extraordinarily with the way I think,too! It's just a numbers game.

Arthur Robey's picture
Arthur Robey
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The thrill of the chase.

What a wonderful frisson! I recognize the truth of this observation. Well done sir.

But how to test the null hypothesis? How to prove the idea wrong? Measure DMT in mouse stool after feeding the Wee, sleekit, cow'rin, tim'rous beastie roundup? (Ref below). But how to measure changes to his world view? Tricky. 

No, it may have to be done by comparing large populations, those exposed to weed killer an those not. Perhaps we can correlate schizophrenia diagnosed people with their gut flora and fecal DMT load and the presents of Roundup markers?

What a difference it would make to the world if everyone was operating to their evolutionary optimum. There is no historical evidence that it would lead to a peaceful world, nor even a sane one. See the works of William Shakespeare, Hereodotus or Melville, but it would, I believe lead to a more creative one, what with the evolutionarily prescribed amount of hallucinogens bathing our brains.

https://en.m.wikipedia.org/wiki/To_a_Mouse

https://en.m.wikipedia.org/wiki/Histories_(Herodotus)

In further news, the Parhomov Cold Fusion experiment has been replicated.  COP =3 (Alain dropped it into my mailbox this morning.)

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I think Chris hit the nail on

I think Chris hit the nail on the head with the gut dysbiosis angle.  There is clear evidence that consuming glyphosate (RoundUp) in our food disrupts the skimate pathway which our gut bacteria DO have, even though WE don't.   And the connection between many brain-involved conditions/diseases such as autism, ADHD, OCD, bipolar with poor gut health has also been well established.

Of course, it might be true that genetics are also involved to some degree, but my guess is that it would also be mighty "convenient" for genetics to be blamed instead, as that would point the finger away from the true source:  big ag and the biotechnology industry, which might be the most powerful industry on the planet.  Maybe blaming faulty genetics is just another diversion that big money can buy to keep their evil lie going that consuming GMO foods, and pesticide-laden foods, are not harmful to our health.

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Arthur Robey
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Serotonin and Mood

It appears that I was wrong about the link between Serotonin and mood. The literature does not support the idea.

My apologies for helping spread this modern equivalent of the old wives tale.

Arthur Robey's picture
Arthur Robey
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Genetic hype.

There was a tidal wave of hype associated with the discovery of the genome that still has to recede. The genome is the template for miraculously eligant amino machinery. It is not the depository of behaviour.

Sheldrake and Lipton have a lot to say about that.

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Interesting thought, but even

Interesting thought, but even if the gut bacteria produced significant quantities of DMT, little to none would enter circulation due to DMT's poor bioavailability:

"Dimethyltryptamine ... is not orally bioavailable because of its first-pass metabolism by MAO.

Goldfrank, L.R., Goldfrank's Toxicologic Emergencies 9th Ed. 2011., McGraw-Hill, New York, N.Y., p. 1029"
https://pubchem.ncbi.nlm.nih.gov/compound/dimethyltryptamine#section=Absorption-Distribution-and-Excretion

If there is anything to your hypothesis, then it would likely involve synthesis of metabolically stable DMT analogues having similar neurotropic activity.

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Hotrod
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Roundup is everywhere

I don't know if this is common knowledge, but many wheat farmers are spraying their wheat with Glyphosate right before harvest to kill weeds, assist in drydown and provide harvest uniformity.  Therefore the bread and pastry you have been consuming very possibly has the "safest weed killer ever" in it.  Isn't that special!!!!

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Burning up at the beach

Longer we keep trudging along like this the nastier the crunch is going to be. Gonna be a doozy.

Arthur Robey's picture
Arthur Robey
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You are worth your birthweight in gold.

Would anyone more knowledgeable than me like like to comment?

https://freedomriver.wordpress.com/what-is-a-birth-certificate/

The Bond is sold to the World Bank (Bank of International Settlements, created in 1931 by the Vatican) as Settlor of the Trust. Your weight in ounces on the Record of Live Birth is to calculate your market value relative to gold. Your Bond becomes a registered Security, which the Treasury uses as Surety for Treasury securities such as Treasury Bonds, Notes and Bills.
So you have been MONETISED. The people truly are the “Credit of the Nation”. However, in the corrupted system, the people’s credit is effectively “human capital”, or “livestock”.
Arthur Robey's picture
Arthur Robey
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From your source

From your source Taco,

(14)C-DMT accumulates in rat brain cortical slices incubated at 37 deg C. ... Most of the accumulated (14)C-DMT was associated with the cytoplasmic fraction. Of the portion associated with the crude mitochondrial fraction, 54.4% was associated with nerve-ending fraction. Abstract: PubMed
 
Sangiah et al; Biol Psychiatry 14 (6): 925-36 (1979)
It would seem DMT does indeed enter the brain.
The MAO is required to prevent the digestive juices in the stomach breaking down the DMT when taken orally, that is true. But we are discussing the flora in the intestine. 
The flora in the large intestine is loaded with DMT, hence the fecal odour.  
 
EDIT: Further, MAOs have to be added to the DMT in the Ayahuasca brew. The brew is taken orally which proves that DMT Can enter the boodstream via the gut. Otherwise there would be no
Ayahuasca experience. 
Time2help's picture
Time2help
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Damn seagulls
Arthur Robey wrote:

Would anyone more knowledgeable than me like like to comment?

https://freedomriver.wordpress.com/what-is-a-birth-certificate/

The Bond is sold to the World Bank (Bank of International Settlements, created in 1931 by the Vatican) as Settlor of the Trust. Your weight in ounces on the Record of Live Birth is to calculate your market value relative to gold. Your Bond becomes a registered Security, which the Treasury uses as Surety for Treasury securities such as Treasury Bonds, Notes and Bills.
So you have been MONETISED. The people truly are the “Credit of the Nation”. However, in the corrupted system, the people’s credit is effectively “human capital”, or “livestock”.

Wouldn't surprise me. Just another circular argument in the massive circle jerk that is our monetary system. Finding that moving forward I'm not getting as upset about these things as I used to. It's kind of like getting mad at the seagull for stealing your sandwich when you weren't paying attention. Seagull's gonna take, that's his nature.

Not condoning, just sayin'.

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we gotta

love our milch coos, milked by hand. there winter hay is drawn by man-n-hoss

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Dependence on big pharm

There was a front page story today in our local paper about a retired nurse who committed suicide jumping from the parking structure of a hospital owned by the company she once worked for.

Her family appears to be blaming the doctors for changing her antidepressants too quickly when the Prozac she had been taking for decades stopped working. My hear goes out to the family and the health care workers. They are both victims of an insane disease management system.

There was mention of how she could not even light her cigarette she was so addled. Over twenty years of depression treated with meds. Most likely her doctors never mentioned smoking cessation, exercise, improved nutrition , healing the gut, probiotics, meditation, etc. Etc. Drugs can be life saving...but you need an exit strategy. This sounded like a case of silver bullet expectations that sadly were unable to be met. Unfortunately I think we will be seeing more and more of this....
Everyone should have a plan b...and I don't mean the next drug in the pipeline.

Arthur Robey's picture
Arthur Robey
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You can ask questions now regarding Parkemov replication.

Moscow researchers Group produce excess heat (COP> 3) at a temperature 1350oS in a stainless steel reactor with fuel nickel + aluminum lithium .

Here is the link.

http://www.lenr-forum.com/forum/index.php/Thread/1870-Moscow-researchers...

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World primed for repeat of ’08 meltdown

World primed for repeat of ’08 meltdown

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Not more knowledgeable, Arthur, but...

The author of this website appears to have noticed parallels between the documents of slavery, and the documents of citizenship.

And while he/she is probably incorrect about this being done deliberately, nonetheless there definitely are parallels, including the fact that the states care less about which state "owns" a person, and more about the fact that EVERY cow must have a bran^H ^H ^H every person must be owned by a state, and pay the fruits of their labor to some state without further cause than that.

But don't be distracted by the claims of legality: God specifically prohibited the numbering of the people, and He does not change; thus, these governments are outside their authority, and their sole basis of action is: "either we steal from you, or we murder you at our discretion". That being the case, the governments have more in common with a Thuggie (deciever) than with an authority.

So what's a Christian to do? If enslaved, continue in that slavery (Paul, new Testament); and remember God's instruction to the exiled Jews: for your rebellion, I am putting you under a wicked king; and I expect you to serve him. Indeed, any rebellion against him I will take as rebellion against Me.

I guess I still have some issues there: God claimed the Israelites as His slaves when He rescued them from slavery in Egypt; but of their enslavement there, there is no record that it was legitimate. Yet it does appear that they were worshipping other gods there, so it may have been real.

There are so many parallels, and it is ugly.

But I guess the hope of the Christian might be described as the following: that after a period of indenture, God intends, promises, and WILL release his slaves into true freedom. None of the other gods do any of the three, because their purpose is that of the thuggie: to decieve, destroy, and ensnare.

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saxplayer00o1
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China’s naked emperors....Even this man sees it

Go ahead and click the link to see who wrote this:

 

"What do Chinese authorities think they’re doing?

In part, they may be worried about financial fallout. It seems that a number of players in China borrowed large sums with stocks as security, so that the market’s plunge could lead to defaults. This is especially troubling because China has a huge “shadow banking” sector that is essentially unregulated and could easily experience a wave of bank runs."........................."The problems of transition to lower growth are obviously major, but we’ve known that for a while. The big news here isn’t about the Chinese economy; it’s about China’s leaders. Forget everything you’ve heard about their brilliance and foresightedness. Judging by their current flailing, they have no clue what they’re doing."

 

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taco
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Arthur, I do not contest that

Arthur,

I do not contest that when appropriately administered (e.g. intravenous, etc.) DMT can reach the brain. However taken orally I argue that it will not reach the brain because as it is absorbed form the intestine, the MAOs present in enterocytes and hepatocytes degrade the DMT before it enters systemic circulation (and therefore before it gets anywhere near the brain).

You argue that the MAOs are present in the stomach and therefore DMT produced in the intestine does not get degraded by MAOs. This would be a solid bit of logic, but I believe that MAOs are not secreted by the stomach.

I can't find any refs that support my claim that there isn't any MAO excreted in the stomach, but I seem to remember that MAO is not a secreted protein in the first place so I would be very surprised if it was in the stomach.

 

--Taco

 

 

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Arthur Robey
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Taco

My apologies. I seem to have misled you. MAO's are not secreted by the stomach. 

It has been reported that some effects can be felt from consuming the caapi vine alone, but that DMT-containing plants (such as Psychotria) remain inactive when drunk as a brew without a source of monoamine oxidase inhibitor (MAOI) such as B. caapi. 

https://en.m.wikipedia.org/wiki/Ayahuasca

Ayahuasca is drunk. The reports are that it tastes foul, which is hardly surprising given that DMT has a fecal odour.

Oral ingestion
 
DMT is broken down by the enzyme monoamine oxidase through a process called deamination, and is quickly inactivated orally unless combined with a monoamine oxidase inhibitor (MAOI).[3
https://en.m.wikipedia.org/wiki/N,N-Dimethyltryptamine
Edit: From the same source, the Lumbar has the most.(100,370 ng/L)
Speculation: this is where the brain stores it's DMT, the lumbar being part of the CNS, and as far from the brain as possible.  
 
reflector's picture
reflector
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ayahuasca
Arthur Robey wrote:

Ayahuasca is drunk. The reports are that it tastes foul, which is hardly surprising given that DMT has a fecal odour.

ayahuasca really does not taste that bad.

bigger issue is the vomiting, which comes at the very beginning of the experience, which seems to happen to most people.

even so, it's a small price to pay for receiving the wisdom of the universe.

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Anyone shed some light on this?

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VeganDB12
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depression-a syndrome no?

I admit to my ignorance about DMT. I see it stimulates serotonin and melatonin. A psychedelic. A recommendation to use illegal substances by a physiican in USA can result in suspension of DEA license and possibly medical license down the road. FYI for those wondering why these treatments aren't discussed in the office. Incuding medical marijuana. Caveat: I also know where schizophrenia in part was caused by massive overuse of this drug. Sorry High Times.  Still many states now admit it has good medicinal uses. 

I think depression is a syndrome with innumerable causes and likely innumerable treatments. Sorry FDA.  There is much more to treating this problem than SSRI, including spiritual (meaningfulness) interventions.

Many correlates with depression thought to have a causal relation:http://www.mayoclinic.org/diseases-conditions/depression/basics/risk-factors/con-20032977 but who knows and who knows if it is the same lesion in all cases? Different causes support use of differential therapuetics.

Drug use/withdrawal/overuse can cut either way, causing it, making it better, making it worse. Remember the time you go drunk and felt better until the next morning when you felt more depressed? Or those who get better on meds then more depressed after stopping medications?

Things doctors are allowed to recommend without losing their license in the US include pharmaceuticals, exercise, therapy, mindfulness meditation and psychotherapy.  The rest is an invitation to get sued or scrutinized when the inevitable bad outcome occurs.

 

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